Familial risk of sleep-disordered breathing

Lundkvist, Karin; Sundquist, Kristina; Li, Xinjun; Friberg, Danielle

doi:10.1016/j.sleep.2012.01.014

Cited by 27 publications

(18 citation statements)

References 30 publications

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“…In agreement, we found that the prevalence of rhinitis was higher in children born by Caesarean section, those with fewer siblings and those whose parents had more education and higher income. On the other hand, children whose parents had more education and higher income had a decreased risk of OSAS, consistent with previous studies which examined the relationship of OSAS and socio‐economic status …”

Section: Discussionsupporting

confidence: 91%

Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome

Park

Lee

et al. 2019

Clinical Respiratory J

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Introduction Rhinitis and obstructive sleep apnea syndrome (OSAS) are different diseases, but have some similar risk factors. Objective The aims of this study were to compare the risk factors and clinical biomarkers for rhinitis and OSAS in children. Methods We examined 3917 children (age 4‐13 years) who were enrolled in a cross‐sectional study conducted in Seongnam, Korea. Their parents completed the Pediatric Sleep Questionnaire (PSQ) for evaluation of OSAS and the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for evaluation of rhinitis. Clinical biomarkers, including total eosinophil count and neutrophil‐lymphocyte ratio (NLR), were measured in a subset of these children. Results OSAS and rhinitis had prevalences of 4.0% and 43.5%, respectively. Body mass index (P < 0.001) and prematurity (P = 0.016) were significantly associated with OSAS, but not with rhinitis. Higher parental education and income increased the risk for rhinitis, but decreased the risk for OSAS. Having more siblings and birth by Cesarean delivery decreased the risk for rhinitis, but living in a new household increased the risk for rhinitis. A short distance of the residence to a main road during pregnancy significantly increased the risk of OSAS. Males, increased exposure to mould, and firstborns had increased risk of OSAS and rhinitis. The NLR was higher in OSAS patients than in those with allergic rhinitis (P = 0.001). Conclusion OSAS and rhinitis shared some risk factors, whereas other factors had inverse association with the two disorders. These results imply that different strategies might be used for prevention of rhinitis and OSAS.

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Section: Discussionsupporting

confidence: 91%

Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome

Park

Lee

et al. 2019

Clinical Respiratory J

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“…This might be due to an underpowering of that group. Previous pediatric studies have reported a higher prevalence of both SDB and OSA in males, although it has been hypothesized that this difference happens mostly at puberty with hormonal changes [26,37]. However, a few studies have concentrated on infants and have also shown a male preponderance for snoring and OSA [38,39].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of children under 2 years of age undergoing tonsillectomy for upper airway obstruction

Côté

Ruiz

Perkins

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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“…Also, low socioeconomic status and race seem to influence the incidence of prenatal and perinatal complications [20]. A recent study also indicates familial clustering of SDB (SDB caused by adenotonsillar or tonsillar hypertrophy), which is an important information for clinicians [21]. …”

Section: Discussionmentioning

confidence: 99%

Habitual snoring and atopic state: correlations with respiratory function and teeth occlusion

et al. 2012

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BackgroundAllergy represents a risk factor at the base of sleep-disordered breathing in pediatric age. Among allergic diseases, the atopy is characterized by a tendency to be “hyperallergic.” Sleep-disordered breathing is also known in orthodontics as correlated with the morphology of craniofacial complex. The aim of this study was to investigate the relation between atopy and sleep-disordered breathing (oral breathers with habitual snoring), comparing atopic children with sleep-disordered breathing (test group) with nonatopic ones with sleep-disordered breathing (control group), in the prevalence of dento-skeletal alterations and other risk factors that trigger sleep-disordered breathing, such as adenotonsillar hypertrophy, turbinate hypertrophy, obesity, and alteration of oxygen arterial saturation.MethodsIn a group of 110 subjects with sleep-disordered breathing (6 to 12 years old), we grouped the subjects into atopic (test group, 60 subjects) and nonatopic (control group, 50 subjects) children and compared the data on the following: skin allergic tests, rhinoscopy, rhinomanometry, night home pulsoxymetry, body mass index, and dento-facial alterations.ResultsEven if our results suggest that atopy is not a direct risk factor for sleep-disordered breathing, the importance of a physiologic nasal respiration in the pathogenesis of sleep-disordered breathing seems to be demonstrated in our study by the higher prevalence of hypertrophy in the adenotonsillar lymphatic tissue, odontostomatological alterations, alterations of the oxygen saturation to pulsoxymetry, and higher prevalence of obesity observed in our children with sleep-disordered breathing, in percentages higher than that of the general pediatric population previously observed in the literature.ConclusionsThe importance of a physiologic nasal respiration in the pathogenesis of sleep-disordered breathing is demonstrated in our study.

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Familial risk of sleep-disordered breathing

Cited by 27 publications

References 30 publications

Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome

Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome

Characteristics of children under 2 years of age undergoing tonsillectomy for upper airway obstruction

Habitual snoring and atopic state: correlations with respiratory function and teeth occlusion

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