1982
DOI: 10.1001/archderm.118.6.423
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Familial occurrence of pemphigus vulgaris

Abstract: Two families with pemphigus vulgaris were observed. In one family, cutaneous and mucous membrane pemphigus developed in a mother and daughter within a nine-year interval. In the other family, pemphigus developed in a brother and sister simultaneously. The diagnosis was confirmed immunopathologically in all four patients. Clinical disease did not develop in the other family members. Studies in families with pemphigus can provide further understanding of genetic and environmental factors involved in the pathogen… Show more

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Cited by 8 publications
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“…HLA typing in the woman and her daughter and sister showed A 26, BW 38 and DRW 4 in all of them. Clinical disease did not develop in the other family members.There have been reports of familial inci dence in pemphigus vulgaris, pemphigus erythematosus, pemphigus foliaceus and pemphigus vegetans [1][2][3][4][5][6], and a high asso ciation of HLA A 26, BW 38 and DRW 4 have also been reported [7,8], We describe here another family occurrence in an uncle and niece of Jewish origin, in which other family members display the typical HLA an tigens but without clinical disease. …”
mentioning
confidence: 70%
“…HLA typing in the woman and her daughter and sister showed A 26, BW 38 and DRW 4 in all of them. Clinical disease did not develop in the other family members.There have been reports of familial inci dence in pemphigus vulgaris, pemphigus erythematosus, pemphigus foliaceus and pemphigus vegetans [1][2][3][4][5][6], and a high asso ciation of HLA A 26, BW 38 and DRW 4 have also been reported [7,8], We describe here another family occurrence in an uncle and niece of Jewish origin, in which other family members display the typical HLA an tigens but without clinical disease. …”
mentioning
confidence: 70%