Familial occurrence of pemphigus foliaceus

HLA Antigens in Jews with Pemphigus Vulgaris

“…In addition, there have been reports of familial occurrence [1]. Recent reports on HLA antigens in pemphigus vulgaris indicate an increased frequency of HLA-A10 [2] and HLA-DRW4, particularly among Jews [3].…”

Familial Pemphigus vulgaris

“…Most of the previous reports of familial pemphigus of various kinds [1][2][3][4][5][6][7] lack immunological or histological confirmation, or both, and there are very few reports of HLA typing [8,9], Large series of nonfamilial pemphigus vulgaris (PV) reported in the literature were found to have an increased frequency of HLA-DR4 among Ashke nazi Jews [10,[12][13][14] and DR4 DRw6 in non-Ashkenazi Jews and non-Jewish Europeans [15].…”