Familial Occurrence of Kawasaki Syndrome in North America

Abstract

Physicians should counsel affected families and make them aware of the potential increased risk of KS among family members.

Kawasaki disease in Malaysia: Biochemical profile, characterization, diagnosis and treatment

“…One of the predisposing factors of KD is family history and, in our study, there was one patient with positive family history of KD. A genetic basis of susceptibility to KD was also observed in other studies while several studies had shown increased incidence of KD among siblings and parents (35, [44][45][46]. Other than that, one patient in our study has a sibling who had ITP.…”

Kawasaki Disease: an Update

“…supports the likely role genetics plays in pathogenesis of KD [5,6]. Several additional findings support a genetic component to KD susceptibility, including: concordance risk in identical twins at~13%, increased incidence of KD in children whose parents have a history of KD, and higher occurrence of KD in siblings of affected patients [7][8][9][10][11][12].…”

Association of Previous Antibiotics Use and Kawasaki Disease: A Cohort Study of 106,908 Patients

“…Finally, while we adjusted for all accessible variables that were thought to be related, including previous infectious diseases, we cannot rule out the possibility of residual confounders owing to some unmeasured or unknown factors (eg, different genetic and socioeconomic confounders, other infections that were not included in the adjustment) that might affect the development of KD (eg, the probability of KD is higher in children with a family history of KD, and patients who tend to visit the hospital frequently are more likely to be prescribed with antibiotics and more likely to be diagnosed with KD). 36,37 The strength of this study is that we could acquire accurate data, including the lifetime antibiotic use, based on a sufficient number of KD cases and controls (n = 106,908). The compulsory national insurance system covers the entire population.…”