Familial Mycosis Fungoides Revisited

Shelley, Walter B.

doi:10.1001/archderm.1980.01640340087024

Cited by 20 publications

(6 citation statements)

References 7 publications

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“…Familial non‐Hodgkin's lymphoma (NHL) cases were collected from two sources: the published medical literature ( Camino, 1975; Greene & Miller, 1978; Shelley, 1980; Greene et al , 1982 ; Haim et al , 1982 ; Veltri et al , 1983 ; Kato et al , 1989 ; Lynch et al , 1992 ; Hayoz et al , 1993 ; Donadieu et al , 1996 ; James et al , 1998 ) from 1926 to the present; and our series of unpublished families with multigenerational NHL. Additional information on one of the published families was obtained by personal communication with the author ( James et al , 1998 ).…”

Section: Methodsmentioning

confidence: 99%

Age of onset evidence for anticipation in familial non‐Hodgkin's lymphoma

Wiernik

Wang

et al. 2000

Br J Haematol

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Summary. Anticipation, a phenomenon in which an inherited disease is diagnosed at an earlier age in each successive generation of a family, has been demonstrated in certain neurological and haematological disorders. This study was conducted to determine whether anticipation occurs in familial non-Hodgkin's lymphoma (NHL). Eleven published reports of multigenerational familial NHL were analysed for evidence of anticipation, together with 18 previously unreported families with familial NHL. Differences in disease-free survival between generations were determined. The difference between age at onset for each affected parent±child pair was tested against the null hypothesis that there was no difference in age at onset. These analyses were also performed separately using only parent± child pairs with age of onset > 25 years to avoid ascertainment bias. In addition, the age at onset distribution of the studied cases was compared with that of the Surveillance Epidemiology and End Results (SEER) Program using data for 1973±98. The median ages at onset in the child and parent generations of all families (48´5 and 71´3 years respectively) and in the selected pairs (52´5 and 71´5 years respectively) were signi®cantly different (P < 0´000002 and P < 0´000001 respectively). The null hypothesis was rejected for all (P < 0´000001) as well as selected pairs (P < 0´000003). A signi®cant difference was observed between the ages of onset of the child generation and the SEER population (P < 0´009), but not between the parent generation and the SEER population. Anticipation occurs in familial NHL, which suggests a genetic basis for it.

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Section: Methodsmentioning

confidence: 99%

Age of onset evidence for anticipation in familial non‐Hodgkin's lymphoma

Wiernik

Wang

et al. 2000

Br J Haematol

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“…The aetiopathogenesis of MF is not well understood and its genetic basis has not been proved. To the best of our knowledge, there are only six cases of familial MF in the literature 2–5 . We report a 37‐year‐old mother and her 5‐year‐old son, both of whom had MF.…”

mentioning

confidence: 89%

“…The first case of familial (mother/daughter) MF was reported by Cameron in 1933 2 and the second case (brother/sister) by Sandbank and Katzenellenbogen in 1968 3 . In 1980 Shelley 4 reported another case of familial MF (father/daughter) and found two additional examples (both brother/sister) which were not fully documented in the literature. MF in identical (male) twins was reported recently 5 .…”

mentioning

confidence: 99%

Familial mycosis fungoides

2002

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“…The etiology of MF is unknown. Genetics and predisposition have been implicated, rarely and not consistently, and cases of familial aggregation are few 3,4 . The prevailing concept is that continuous activation of skin T helper lymphocytes by diverse exogenic antigens results in the malignant transformation of a specific clone.…”

Section: Epidemiologymentioning

confidence: 99%