2010
DOI: 10.1210/jc.2010-0875
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Abstract: Our findings support the previous observation that low thyroid activity in humans constitutes a heritable phenotype that contributes to exceptional familial longevity observed in the Leiden Longevity Study.

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Cited by 108 publications
(86 citation statements)
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References 18 publications
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“…The study focused on a specific class of patients (very older people), for this reason, the results should be rigorously interpreted, also considering the weakness of observational studies. However, these data together with the results obtained by Rozing et al, (2010) that demonstrated a possible genetic predisposition of nonagenarians to a decrease function of hypothalamus-pituitary-thyroid axis, suggest that the oldest old may represent a different population respect to moderate old people or young adults. Potential explanations for these age differences might be competing mortality among older adults (for example, due to cancer) or more competing risk factors for CHD among older adults (for example, age or sex).…”
Section: Clinical Evidencesmentioning
confidence: 80%
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“…The study focused on a specific class of patients (very older people), for this reason, the results should be rigorously interpreted, also considering the weakness of observational studies. However, these data together with the results obtained by Rozing et al, (2010) that demonstrated a possible genetic predisposition of nonagenarians to a decrease function of hypothalamus-pituitary-thyroid axis, suggest that the oldest old may represent a different population respect to moderate old people or young adults. Potential explanations for these age differences might be competing mortality among older adults (for example, due to cancer) or more competing risk factors for CHD among older adults (for example, age or sex).…”
Section: Clinical Evidencesmentioning
confidence: 80%
“…Overall these data seem to suggest that ageing is associated with a certain degree of down regulation of the hypothalamuspituitary-thyroid-peripheral axis, although the clinical significance of such condition is far to be elucidated. To this regard, Rozing et al (2010) reported that the offspring of nonagenarian siblings presented a lower thyroidal sensitivity to TSH and a paradoxical beneficial cardiometabolic profile as compared to their partners. The authors concluded that the favorable role of low thyroid hormone metabolism on health and longevity, already observed in animal models, might be applicable to humans as well.…”
Section: Thyroid Function and Ageingmentioning
confidence: 99%
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“…The hypothesis of an adaptive and protective effect of abnormal thyroid function in CKD patients has been suggested [3]. Recently, several studies reported that elevated serum TSH level is associated with longevity [4,5]. However, the effect of thyroid function on CKD is unclear.…”
Section: Commentarymentioning
confidence: 99%
“…relates with a lower mortality rate in people aged 85 plus [46,47,48,49], while lower fT4 levels correlate with good physical efficiency in elderly people (73-94 years of age) and a decreased risk of death [23,47,48,50].…”
Section: Niedoczynność Tarczycy W Podeszłym Wiekumentioning
confidence: 99%