Familial dyskeratotic comedones

Carneiro, S. J.

doi:10.1001/archderm.105.2.249

Cited by 11 publications

(3 citation statements)

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“…Histopathological findings include non-specific acanthoma with papillomatosis [10] – with incidental acantholysis present in two lesions, as reported by Schwartz and Burgess [11] – and no signs of dyskeratosis. Similar to our cases, familial dyskeratotic comedones are dyskeratotic cells at the bottom of comedo-like lesions [12]. However, in our cases, the depressions on the skin surface were smaller, the dyskeratotic cells were not accompanied by acantholysis [13,14] and, moreover, there were characteristic columns of dyskeratotic cells within the stratum corneum.…”

Section: Discussionsupporting

confidence: 84%

Two Case Reports of Columnar Dyskeratosis, an Unusual Keratinisation Disorder

Pock¹,

Štork

2010

Dermatology

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Keratinisation disorders with distinctive histopathological patterns are few in number. We describe two men with unusual dermatosis, characterised by a distinctive pattern of focal dyskeratosis. Both men suffered from generalised dermatosis formed by verrucous red-brown plaques. Repeated skin biopsies showed the same histopathological pattern with foci of vertically oriented dyskeratotic cells. The dyskeratotic cells on the level of the stratum spinosum and granulosum were positive for AE1/AE3, CK-HW, CK-LS and CK116 immunostaining. PCR for HPV was negative. The similar clinical appearance of skin lesions in both patients together with their identical histopathological pictures seems to represent a unique clinicopathological condition that we believe is best described by the term ‘columnar dyskeratosis’.

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Section: Discussionsupporting

confidence: 84%

Two Case Reports of Columnar Dyskeratosis, an Unusual Keratinisation Disorder

Pock¹,

Štork

2010

Dermatology

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“…Nevus comedonicus is a not so common benign hamartoma characterized by a closely set band of slightly elevated papules topped with darkened keratin plugs arranged in linear or zosteriform groups giving a sieve like appearance. It is due to a defect in the embryologic development of the hair follicle, aplasia or hypoplasia of the sebaceous gland (Carneiro et al, 1972;Sweitzer and Winer, 1932). These lesions appear mostly at birth or child hood (Givan et al, 2010;Guldbakke et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Zosteriform Nevus Comedonicus

Babbita¹,

A²,

Sathyanarayanana³

et al. 2020

ijrps

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Nevus comedonicus is an uncommon cutaneous developmental defect of follicular apparatus characterized by unilateral and linear distribution of bundles of dilated hair follicles filled with keratin plugs. It is usually seen on the head and neck region, trunk and upper arm. This condition may be present at birth or can occur later in life. The term nevus comedonicus is a misnomer as there are no true comedones and is better termed as follicular keratotic nevus. It is also known as nevus zoniforme or nevus acneiformis unilateralis. There are two types of nevus comedonicus, namely inflammatory and non-inflammatory (non-pyogenic). When nevus comedonicus is manifested with other extracutaneous symptoms, it is termed as nevus comedonicus syndrome. Diagnosis is mainly clinical, based on history and typical morphology. As the disease runs a benign course, no aggressive treatment is required. Patients seek treatment, especially for cosmetic purposes and inflammatory type of lesions. Various treatment modalities like topical therapy, surgical excision, lasers are available and treatment options are individualized based on the size and extent of the lesion. We herein present a case of unilateral nevus comedonicus with no systemic associations in a 30-year-old female on her lower limb which is not a common site of occurrence.

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“…It is clinically characterized by numerous, discrete, disseminate, hyperkeratotic papules, and comedones. [ 1 2 3 4 5 6 7 8 9 10 ] On histopathology, it shows crater-like invaginations filled with keratinous material and evidence of dyskeratosis. [ 4 5 6 7 8 9 10 ] To the best of our knowledge, only 15 patients from seven families have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%