Familial Diffuse Cortical Dysplasia

Bilateral parasagittal parietooccipital polymicrogyria and epilepsy

“…Ferrie and colleagues [43] described 2 brothers with agyria-pachygyria of the temporal, occipital, and parietal lobes, associated with colpocephaly, reduced white matter, and small zones of infolding, possibly indicating discrete areas of polymicrogyria. However, this malformative pattern suggests earlier origin and more extensive brain involvement than that found in our patients, and resembles that described by Kuzniecky [44,451 in another 2 brothers as familial diffuse cortical dysplasia.…”

Bilateral parasagittal parietooccipital polymicrogyria and epilepsy

“…Ferrie and colleagues [43] described 2 brothers with agyria-pachygyria of the temporal, occipital, and parietal lobes, associated with colpocephaly, reduced white matter, and small zones of infolding, possibly indicating discrete areas of polymicrogyria. However, this malformative pattern suggests earlier origin and more extensive brain involvement than that found in our patients, and resembles that described by Kuzniecky [44,451 in another 2 brothers as familial diffuse cortical dysplasia.…”

Surgical outcome of cortical dysplasias presenting with chronic intractable epilepsy: A 10-year experience

“…However, our study was unusual in that a very significant number of cases (49.1%, 28/57 patients) had coexisting pathologies in the form of DNT (12) and gangliogliomas (16) and MTS (1) as compared to earlier studies. [20][21][22][23][24] In all these cases, the diagnosis of CD was made only after histopathological examination.…”

“…The good outcome in our series (51%) seems to be comparable to what has been usually quoted in the literature. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] However, we do submit the lacunae of the present study. Firstly it is a retrospective study.…”

Autosomal recessive frontotemporal pachygyria

“…Other unique forms of inherited pachygyria have also been described. Kuzniecky et al described two brothers with bilateral diffuse pachygyria primarily located over the parietal region, resulting in moderate mental retardation and atonic and generalized seizures [Kuzniecky, 1994]. In those two brothers, the frontal and occipital regions were relatively spared, unlike in our family, where the frontal areas were most affected.…”

Bilateral parasagittal parietooccipital polymicrogyria and epilepsy

“…Ferrie and colleagues [43] described 2 brothers with agyria-pachygyria of the temporal, occipital, and parietal lobes, associated with colpocephaly, reduced white matter, and small zones of infolding, possibly indicating discrete areas of polymicrogyria. However, this malformative pattern suggests earlier origin and more extensive brain involvement than that found in our patients, and resembles that described by Kuzniecky [44,451 in another 2 brothers as familial diffuse cortical dysplasia.…”

Surgical outcome of cortical dysplasias presenting with chronic intractable epilepsy: A 10-year experience

“…However, our study was unusual in that a very significant number of cases (49.1%, 28/57 patients) had coexisting pathologies in the form of DNT (12) and gangliogliomas (16) and MTS (1) as compared to earlier studies. [20][21][22][23][24] In all these cases, the diagnosis of CD was made only after histopathological examination.…”

“…The good outcome in our series (51%) seems to be comparable to what has been usually quoted in the literature. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] However, we do submit the lacunae of the present study. Firstly it is a retrospective study.…”

Autosomal recessive frontotemporal pachygyria

“…Other unique forms of inherited pachygyria have also been described. Kuzniecky et al described two brothers with bilateral diffuse pachygyria primarily located over the parietal region, resulting in moderate mental retardation and atonic and generalized seizures [Kuzniecky, 1994]. In those two brothers, the frontal and occipital regions were relatively spared, unlike in our family, where the frontal areas were most affected.…”

Bilateral parasagittal parietooccipital polymicrogyria and epilepsy

“…Ferrie and colleagues [43] described 2 brothers with agyria-pachygyria of the temporal, occipital, and parietal lobes, associated with colpocephaly, reduced white matter, and small zones of infolding, possibly indicating discrete areas of polymicrogyria. However, this malformative pattern suggests earlier origin and more extensive brain involvement than that found in our patients, and resembles that described by Kuzniecky [44,451 in another 2 brothers as familial diffuse cortical dysplasia.…”

Surgical outcome of cortical dysplasias presenting with chronic intractable epilepsy: A 10-year experience

“…However, our study was unusual in that a very significant number of cases (49.1%, 28/57 patients) had coexisting pathologies in the form of DNT (12) and gangliogliomas (16) and MTS (1) as compared to earlier studies. [20][21][22][23][24] In all these cases, the diagnosis of CD was made only after histopathological examination.…”

“…The good outcome in our series (51%) seems to be comparable to what has been usually quoted in the literature. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] However, we do submit the lacunae of the present study. Firstly it is a retrospective study.…”

Autosomal recessive frontotemporal pachygyria

“…Other unique forms of inherited pachygyria have also been described. Kuzniecky et al described two brothers with bilateral diffuse pachygyria primarily located over the parietal region, resulting in moderate mental retardation and atonic and generalized seizures [Kuzniecky, 1994]. In those two brothers, the frontal and occipital regions were relatively spared, unlike in our family, where the frontal areas were most affected.…”