Familial Aggregation of Oesophageal Cancer in Yangcheng County, Shanxi Province, China

Hu, Naibo; Sm, Dawsey; Wu, Mei‐Hwan; Bonney, Ge; He, Lijun; Han, Xiao; M, Fu; Pr, Taylor

doi:10.1093/ije/21.5.877

Cited by 76 publications

(67 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,10,17 In our study, increased risk of the ESCC and GCC were found among people with a family history of esophageal cancer, and the risk increased with the number of first-degree relatives who had this disease. The role of genetics in the development of esophageal cancer is also supported by previous reports of familial aggregation of esophageal cancer 29,30 and by one segregation analysis of esophageal cancer pedigrees that suggested an autosomal recessive Mendelian inheritance pattern. 31 Recent molecular studies also support a role for genetic susceptibility in the etiology of ESCC in this area.…”

Section: Discussionsupporting

confidence: 55%

Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China

Tran

Sun

Abnet

et al. 2004

Intl Journal of Cancer

608

576

View full text Add to dashboard Cite

Esophageal cancer incidence and mortality rates in Linxian, China are among the highest in the world. We examined risk factors for esophageal squamous cell carcinoma (ESCC), gastric cardia cancer (GCC), and gastric noncardia cancer (GNCC) in a populationbased, prospective study of 29,584 adults who participated in the Linxian General Population Trial. All study participants completed a baseline questionnaire that included questions on demographic characteristics, personal and family history of disease, and lifestyle factors. After 15 years of follow-up, a total of 3,410 incident upper gastrointestinal cancers were identified, including 1,958 ESCC, 1,089 GCC and 363 GNCC. Cox proportional hazard models were used to estimate risks. Increased age and a positive family history of esophageal cancer (including ESCC or GCC) were significantly associated with risk at all 3 cancer sites. Additional risk factors for ESCC included being born in Linxian, increased height, cigarette smoking and pipe smoking; for GCC, male gender, consumption of moldy breads and pipe smoking; and for GNCC, male gender and cigarette smoking. Protective factors for ESCC included formal education, water piped into the home, increased consumption of meat, eggs and fresh fruits and increased BMI; for GCC, formal education, water piped into the home, increased consumption of eggs and fresh fruits and alcohol consumption; and for GNCC, increased weight and BMI. General socioeconomic status (SES) is a common denominator in many of these factors and improving SES is a promising approach for reducing the tremendous burden of upper gastrointestinal cancers in Linxian.Key words: gastric cardia cancer; gastric noncardia cancer; cohort studies; diet; smoking Esophageal cancer is the sixth most common cause of cancerrelated death worldwide. 1 Some of the world's highest incidence and mortality rates of esophageal cancer occur in China. 2,3 Considerable geographic variation exists in these rates across the country, with the most prominent cluster seen in North Central China, particularly in Lin county (Linxian). 3,4 Esophageal cancer mortality rates in Linxian exceed the Chinese average rates by 10-fold and the rates among Caucasian Americans by 100-fold. 5 In Linxian, esophageal squamous cell carcinoma and gastric cardia cancer are both frequent and have traditionally been considered a single disease, esophageal cancer, because of their similar symptoms. Reasons for the unusually high rates of esophageal and gastric cardia cancers in the Linxian population are unclear, but recent reports suggest that rates have begun to decline. 6 Although tobacco smoking and alcohol drinking account for over 90% of esophageal squamous cell carcinoma in the West, 7,8 previous studies have shown that they are not important contributing factors to the development of cancer in Linxian. 9,10 The geographic variation in occurrence in China strongly suggests that environmental or lifestyle factors are major contributors to the etiology of esophageal/gastric cardia cancer. Diet ha...

show abstract

Section: Discussionsupporting

confidence: 55%

Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China

Tran

Sun

Abnet

et al. 2004

Intl Journal of Cancer

608

576

View full text Add to dashboard Cite

show abstract

“…Although epidemiologic studies indicate that tobacco and alcohol consumption are the major risk factors for squamous esophageal cancer in the low-risk regions of Europe and North America, the etiologic agents in high-risk regions have yet to be convincingly identified. Previous studies in high-risk regions showed a strong tendency toward familial aggregation (3,4), suggesting that genetic susceptibility may play a role in the pathogenesis of ESCC.…”

Section: Introductionmentioning

confidence: 91%

Downregulation of RBMS3 Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma

Chen

Nie

et al. 2011

Cancer Research

View full text Add to dashboard Cite

Deletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. Cancer Res; 71(19); 6106-15. Ó2011 AACR.

show abstract

“…Esophageal squamous cell carcinoma (ESCC) is very common in many areas of China, especially in Shanxi Province (Hu et al, 1992). In previous studies in Shanxi Province, we found frequent loss of heterozygosity (LOH) on chromosome 13q (Hu et al, 1999.…”

Section: Introductionmentioning

confidence: 99%

Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma

et al. 2003

Oncogene

View full text Add to dashboard Cite

Previous studies have shown frequent allelic loss on chromosome 13 in esophageal squamous cell carcinoma (ESCC). We assessed the frequency of allelic loss on chromosome 13q14 and mutations of deleted in cancer 1 (DICE1) (also found on 13q14) in ESCC patients to determine if this candidate tumor suppressor gene has a role in the development of ESCC, and whether this gene was an inactivation target for allelic loss on chromosome 13q14. Initially, we examined allelic loss at five markers flanking DICE1 in 56 ESCC patients from Shanxi Province, China, and then examined the entire coding sequence of this gene for mutations using polymerase chain reaction-single-strand confirmation polymorphism (PCR-SSCP) analysis and DNA sequencing. Subsequently, we extended our evaluation to an additional 80 ESCC patients and 232 healthy individuals to confirm the germline variant found in the initial 56 ESCC patients. The frequencies of allelic loss were 71, 58, and 75% for D13S325, D13S757, and D13S887, respectively, in the initial 56 ESCC patients studied. Overall, 73% of informative patients had loss of heterozygosity (LOH) for at least one of these three markers. Somatic mutations were identified in three patients (3/56, 5%), and one novel polymorphism was identified in 3% of ESCC patients (4/ 136) and 3% of healthy individuals (6/232). We conclude that DICE1 mutations occur in ESCC but are infrequent. The candidate tumor suppressor gene corresponding to the frequent allelic loss on chromosome 13q14 in ESCC remains unknown.

show abstract

Familial Aggregation of Oesophageal Cancer in Yangcheng County, Shanxi Province, China

Cited by 76 publications

References 0 publications

Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China

Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China

Downregulation of RBMS3 Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma

Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma

Contact Info

Product

Resources

About