Familial aggregation of ischemic stroke in young women: the Stroke Prevention in Young Women Study

MacClellan, Leah R.; Mitchell, Braxton D.; Cole, John W.; Wozniak, Marcella A.; Stern, Barney J.; Giles, Wayne H.; Brown, David W.; Sparks, Mary J.; Kittner, Steven J.

doi:10.1002/gepi.20171

“…For TIA, ischemic stroke, and subclinical lesions in the brain, the association with MA has been demonstrated in case-control and crosssectional studies, summarized in meta-analyses, [25][26][27] and demonstrated in large longitudinal studies. 3,4,28 Due to the association between migraine (mostly MA) and ischemic stroke, it is of interest whether migraine is similarly associated with coronary heart disease as well. Although some studies yielded negative results, 29 case reports 30 and cohort studies 9 found an association between migraine and chest pain, and with ischemic electrocardiographic changes.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] MA seems also to be associated with ischemic heart disease, claudication, and cardiovascular mortality. [7][8][9] Indeed, it has been speculated that migraine may be a risk factor for atherosclerotic disease in general.…”

mentioning

confidence: 99%

Migraine and cardiovascular disease

Bigal¹,

Kurth

²

,

Santanello³

et al. 2010

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Objectives: Although the relationship between migraine and cardiovascular disease (CVD) has been studied, several questions remain unanswered. Herein we contrast the rate of diagnosed CVD as well as of risk factors for CVD in individuals with migraine with and without aura (MA and MO) and in controls. Methods:In this case-control study, migraineurs (n ϭ 6,102) and controls (n ϭ 5,243) were representative of the adult US population. Headache diagnosis was formally assigned using a validated mailed questionnaire which also obtained details on treatment, comorbidities, and other variables. CVD events were obtained based on self-reported medical diagnosis. Risk factors for CVD and modified Framingham scores were computed. Results:In unadjusted analyses, migraine overall and MA were associated with myocardial infarction, stroke, and claudication, and MO was associated with myocardial infarction and claudication. Migraineurs were more likely than controls to have a medical diagnosis of diabetes (12.6% vs 9.4%, odds ratio [OR] 1.4, 95% confidence interval [CI] 1.2-1.6), hypertension (33.1% vs 27.5%, OR 1.4, 95% CI 1.3-1.6), and high cholesterol (32.7% vs 25.6%, OR 1.4, 95% CI 1.3-1.5). Risk was highest in MA, but remained elevated in MO. Framingham scores were significantly higher in MO and MA than in controls. After adjustments (gender, age, disability, treatment, CVD risk factors), migraine remained significantly associated with myocardial infarction (OR 2.2, 95% CI 1.7-2.8), stroke (OR 1.5, 95% CI 1.2-2.1), and claudication (OR 2.69, 95% CI 1.98 -3.23). Conclusion:Both migraine with and without aura are associated with cardiovascular disease (CVD) and with risk factors for CVD. However, since our sample size is large, the clinical relevance of the differences is yet to be established. Neurology ® 2010;74:628 -635

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“…Controversial topics included whether migraine without aura (MO) was also a risk factor to stroke, if the association also happened in men, and whether migraine was associated with other forms of cardiovascular disease 3 . The field has advanced considerably in recent years, with the publication of evidence that MA is indeed an established risk factor for subclinical ischemic lesions of the brain 4 , as well as for ischemic stroke, particularly among women of younger age 5,6 . The association has also been shown in men 7 .…”

mentioning

confidence: 99%

Migraine and cardiovascular disease

Bigal

¹

2011

Arq. Neuro-Psiquiatr.

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Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality. The topic is therefore of considerable interest. Accordingly, herein we review the association between migraine and cardiovascular disease. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis. Key words: migraine, cardiovascular disease, stroke. Migrânea e doenças cardiovasculares RESUMOA migrânea, especialmente a migrânea com aura, é fator de risco para lesões cerebrais. Evidência recente sugere que migrânea com e sem aura é associada com outras doenças cardiovasculares isquêmicas, incluindo a angina, o infarto do miocárdio, revascularização coronária, claudicação e morte súbita. Iniciamos discutindo o diagnóstico da migrânea e seus mecanismos fisiopatológicos. Após sumarizar a evidência, discutimos resultados de meta-análise recente. Por fim, ressaltamos resultados de um grande estudo populacional sobre o assunto. Palavras-chave: migrânea, doença cardiovascular, acidente vascular cerebral.

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“…The relationship was stronger in young women, and was magnified by the use of hormonal contraception or by tabagism 1 . Controversial topics included whether migraine without aura (MO) was also a risk factor to stroke, if the association also happened in men, and whether migraine was associated with other forms of cardiovascular disease 3 .The field has advanced considerably in recent years, with the publication of evidence that MA is indeed an established risk factor for subclinical ischemic lesions of the brain 4 , as well as for ischemic stroke, particularly among women of younger age 5,6 . The association has also been shown in men 7 .…”

mentioning

confidence: 99%

“…The field has advanced considerably in recent years, with the publication of evidence that MA is indeed an established risk factor for subclinical ischemic lesions of the brain 4 , as well as for ischemic stroke, particularly among women of younger age 5,6 . The association has also been shown in men 7 .…”

mentioning

confidence: 99%

Migraine and Cardiovascular Disease

Lipton¹,

Bigal

²

2006

JAMA

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Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality. The topic is therefore of considerable interest. Accordingly, herein we review the association between migraine and cardiovascular disease. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis. Key words: migraine, cardiovascular disease, stroke. Migrânea e doenças cardiovasculares RESUMOA migrânea, especialmente a migrânea com aura, é fator de risco para lesões cerebrais. Evidência recente sugere que migrânea com e sem aura é associada com outras doenças cardiovasculares isquêmicas, incluindo a angina, o infarto do miocárdio, revascularização coronária, claudicação e morte súbita. Iniciamos discutindo o diagnóstico da migrânea e seus mecanismos fisiopatológicos. Após sumarizar a evidência, discutimos resultados de meta-análise recente. Por fim, ressaltamos resultados de um grande estudo populacional sobre o assunto. Palavras-chave: migrânea, doença cardiovascular, acidente vascular cerebral. The association between migraine and ischemic vascular events has been studied for many years 1,2 . Original studies controversially reported an association between migraine with aura (MA) and stroke. The relationship was stronger in young women, and was magnified by the use of hormonal contraception or by tabagism 1 . Controversial topics included whether migraine without aura (MO) was also a risk factor to stroke, if the association also happened in men, and whether migraine was associated with other forms of cardiovascular disease 3 .The field has advanced considerably in recent years, with the publication of evidence that MA is indeed an established risk factor for subclinical ischemic lesions of the brain 4 , as well as for ischemic stroke, particularly among women of younger age 5,6 . The association has also been shown in men 7 . Furthermore, migraine seems also to be linked with other forms of cardiovascular disease (CVD), including myocardial infarct, angina and claudication), as well as with risk factors to CVD 8,9 . The topic has indeed gained considerable traction and robust evidence is now available. Accordingly, herein we review the association between migraine and CVD. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis. Migraine...

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Familial aggregation of ischemic stroke in young women: the Stroke Prevention in Young Women Study

Abstract: We conclude that young-onset stroke aggregates in families and that the magnitude of aggregation increases with decreasing proband age.

Cited by 54 publications

References 15 publications

Migraine and cardiovascular disease

Migraine and cardiovascular disease

Migraine and cardiovascular disease

Migraine and Cardiovascular Disease

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