Failure of Implanon&amp;reg; on antituberculous therapy

Gbolade, B. A.

doi:10.2147/oajc.s12194

Cited by 13 publications

(14 citation statements)

References 22 publications

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“…Its main mechanism of action is ovulation suppression, augmented by increased cervical mucus viscosity that hinders the passage of spermatozoa and alters the endometrial lining [2, 4]. …”

Section: Introductionmentioning

confidence: 99%

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Determinant of Implanon Discontinuation among Women Who Ever Used Implanon in Diguna Fango District, Wolayita Zone, Southern Ethiopia: A Community Based Case Control Study

Tadesse

Kondale

Agedew

et al. 2017

International Journal of Reproductive Medicine

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Background A significant number of women make Implanon their first choice of contraception. However, they discontinue their Implanon before its expiry date was high, but factors that contribute to discontinuing their Implanon were poorly described in Ethiopia. Methods A community based unmatched case control study was conducted. Then simple random sampling technique was used to select 340 women. Data was collected by nurses using face to face interview. Epi-Info version 7 and SPSS 20 software were used. Bivariate and multiple logistic regressions were performed with COR and AOR with 95% CI. Findings Having preinsertion counseling (AOR: 0.36, 95% CI: 0.20–0.64), having follow-up appointment (AOR: 0.35, 95% CI: 0.2–0.62), age at insertion <20 years (AOR: 3, 95% CI: 1.16–7.8), women who had no formal education (AOR: 2.8, 95% CI: 1.31–6.11), women who had ≤4 children (AOR: 1.8, 95% CI: 1.01–3.21), and women who had previous abortion history (AOR: 2.3, 95% CI: 1.10–4.63) were determinants of Implanon discontinuation. Conclusions Policy makers and concerned bodies should take into account future intervention and also great emphasis should be given to follow-up appointment and counseling services, especially counseling on side effects, and informed choice for clients after Implanon insertion.

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“…Its main mechanism of action is ovulation suppression, augmented by increased cervical mucus viscosity that hinders the passage of spermatozoa and alters the endometrial lining [2, 4]. …”

Section: Introductionmentioning

confidence: 99%

“…More than 4.5 million women have used Implanon worldwide [4, 6]. In sub-Saharan Africa, a growing number of women and sexually active adolescents are using family planning, and many are choosing contraceptive implants [7].…”

Section: Introductionmentioning

confidence: 99%

Determinant of Implanon Discontinuation among Women Who Ever Used Implanon in Diguna Fango District, Wolayita Zone, Southern Ethiopia: A Community Based Case Control Study

Tadesse

Kondale

Agedew

et al. 2017

International Journal of Reproductive Medicine

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“…Common hepatic enzyme AED inducers include phenytoin, phenobarbital, oxcarbazepine, topiramate, and carbamazepine [19,21,22]. Nonnucleoside reverse transcriptase inhibitors (efavirenz) and antituberculosis medications (isoniazid) also have CYP induction properties [23,24]. These medications induce the CYP450 3A4 system to accelerate the metabolism of estrogen and progestin; thereby decreasing the available serum concentration of progestin [19,21,22].…”

Section: Discussionmentioning

confidence: 99%

Unintended Pregnancy with Implantable Subdermal Contraceptive Device (Nexplanon): A Case Report

Rezai¹,

Patel²,

Hughes³

et al. 2018

OGIJ

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Background: In 2006, Implanon (68 mg), a synthetic subcutaneous progestin etonogestrel eluting capsule, was approved for use in the U.S. to provide longacting reversible contraception (LARC). The next generation LARC, Nexplanon (68 mg), a progestin-only etonogestrel subdermal implant, was available in 2001. Currently, Nexplanon is advertised to provide 99% effective contraception, up to 4 years. Removal of the capsule will revert back to normal menstruation and fertility. Unlike Implanon, cases of unintended uterine pregnancy with proper and successful insertion have not been reported using Nexplanon. Case:A 24-year-old female, G2P1001, with obstetrical history of one spontaneous vaginal delivery (2015), and gynecological history of low grade squamous intraepithelial lesion (LSIL) on Pap smear (2014), was found to have an intrauterine pregnancy while using Nexplanon. Initially, urine pregnancy testing assured that she was not pregnant before placement of the Nexplanon. Nexplanon was inserted ~2 months post-partum after the birth of her first child.17 months post-Nexplanon insertion, patient experienced irregular spotting, cramping, and reported positive home pregnancy test. Transvaginal ultrasound confirmed an intrauterine pregnancy at 9 weeks and 3 days. The Nexplanon implant was removed intact. Routine prenatal care was initiated and no issues were identified. Conclusion:Newer LARCs provide an alternative to lifestyle adaptive contraception, with ease of use and compliance. Although LARCs prove to be more effective, known factors linked to human error during placement, cytochrome P450 induction, and BMI, have shown to decrease their efficacy, leading to failed contraception. be associated with an unintended uterine pregnancy with proper and successful insertion. Keywords:Contraindications for the implant include; known or suspected pregnancy, current or past history of thrombosis or thromboembolic disorders, liver tumors (benign or malignant), active liver disease, undiagnosed abnormal genital bleeding, known or suspected breast cancer, personal history of breast cancer, other progestin-sensitive cancer and allergies to the components of Nexplanon [12,13]. Side effects of Nexplanon include; irregular menses, headache, vaginitis, breast pain, weight gain, acne, abdominal pain, and pharyngitis [12,13]. Although Nexplanon is used to prevent pregnancy, if the implant fails, there is an increased risk for ectopic pregnancy [12]. We present the first case of intrauterine pregnancy while using Nexplanon [14]. Case ReportThis patient is a 24-year-old female, G2P1001, with past medical history of asthma controlled with albuterol, asthmatic bronchitis treated with amoxicillin, and iron deficiency anemia was found to have an intrauterine pregnancy while using Nexplanon. Obstetrical history is significant for one spontaneous vaginal delivery in 2015, and gynecological history includes low grade squamous intraepithelial lesion (LSIL) on pap smear in 2014, with no further abnormal pap smears. She had used Nexplanon ...

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“…Additionally, this case series identified that a number of failures occurred as a result of concomitant use of enzyme inducing drugs (Harrison-Woolrych and Hill 2005). Other reports of failures possibly as a consequence of drug interactions are documented (Patni et al 2006;Lakhi and Govind 2010;McCarty et al 2011;Matiluko et al 2007;Haukkamaa 1986;Gbolade 2010): product information warns that efficacy may be reduced with concomitant use of drugs which induce hepatic enzymes, specifically cytochrome P450, for example carbamazepine or rifampacin (Merck Sharp and Dohme Limited 2013). In 2014, the Medicines and Healthcare Regulatory Agency (MHRA) in the UK produced a Drug Safety Update (Medicines and Healthcare Products Regulatory Agency 2014) which highlighted that in the last quarter of 2013 the MHRA had received two reports of unintended pregnancies occurring in women using the etonogestrel implant possibly as a consequence of using St John's Wort.…”

Section: Efficacy and Unintended Pregnanciesmentioning

confidence: 94%

Medicines For Women

Harrison‐Woolrych¹

2015

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Failure of Implanon® on antituberculous therapy

Cited by 13 publications

References 22 publications

Determinant of Implanon Discontinuation among Women Who Ever Used Implanon in Diguna Fango District, Wolayita Zone, Southern Ethiopia: A Community Based Case Control Study

Determinant of Implanon Discontinuation among Women Who Ever Used Implanon in Diguna Fango District, Wolayita Zone, Southern Ethiopia: A Community Based Case Control Study

Unintended Pregnancy with Implantable Subdermal Contraceptive Device (Nexplanon): A Case Report

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