Faecalibacterium prausnitzii Improves Lipid Metabolism Disorder and Insulin Resistance in Type 2 Diabetic Mice

Xuan, Wenting; Ou, Yijing; Chen, Wenting; Huang, Lijuan; Wen, Chuangyu; Huang, Guang-ying; Tang, Wenting; Zeng, Daidi; Huang, Suran; Xiao, Lijuan; Li, Zhongjun

doi:10.3389/bjbs.2023.10794

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…In particular, A. muciniphila, Bifidobacterium longum, Clostridium leptum group, Faecalibacterium prausnitzii, and Faecalibacterium were the taxa selected as relevant for the study of prevention strategies against metabolic diseases [242]. For instance, Faecalibacterium prausnitzii is a butyrate-producing bacteria inversely associated with type II diabetes, also described as a therapeutic option to decrease fasting glucose and IR in diabetic patients [243]. Thus, SCFA-producing bacteria (such as A. muciniphila) might be a mechanistic link between exercise-inducing irisin and BDNF and the positive impact on NPSs in AD.…”

Section: Irisin and Bdnf As "Ideal" Players Connecting Physical Activ...mentioning

confidence: 99%

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

Cutuli,

Decandia,

Giacovazzo

et al. 2023

IJMS

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Alzheimer’s disease (AD) is a common cause of dementia characterized by neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms. Physical exercise (PE) has emerged as a powerful tool for reducing chronic inflammation, improving overall health, and preventing cognitive decline. The connection between the immune system, gut microbiota (GM), and neuroinflammation highlights the role of the gut–brain axis in maintaining brain health and preventing neurodegenerative diseases. Neglected so far, PE has beneficial effects on microbial composition and diversity, thus providing the potential to alleviate neurological symptoms. There is bidirectional communication between the gut and muscle, with GM diversity modulation and short-chain fatty acid (SCFA) production affecting muscle metabolism and preservation, and muscle activity/exercise in turn inducing significant changes in GM composition, functionality, diversity, and SCFA production. This gut–muscle and muscle–gut interplay can then modulate cognition. For instance, irisin, an exercise-induced myokine, promotes neuroplasticity and cognitive function through BDNF signaling. Irisin and muscle-generated BDNF may mediate the positive effects of physical activity against some aspects of AD pathophysiology through the interaction of exercise with the gut microbial ecosystem, neural plasticity, anti-inflammatory signaling pathways, and neurogenesis. Understanding gut–muscle–brain interconnections hold promise for developing strategies to promote brain health, fight age-associated cognitive decline, and improve muscle health and longevity.

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Section: Irisin and Bdnf As "Ideal" Players Connecting Physical Activ...mentioning

confidence: 99%

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

Cutuli,

Decandia,

Giacovazzo

et al. 2023

IJMS

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Microbial network inference for longitudinal microbiome studies with LUPINE

Kodikara,

Lê Cao

2024

Preprint

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The microbiome is a complex ecosystem of interdependent taxa that has traditionally been studied through cross-sectional studies. However, longitudinal microbiome studies are becoming increasingly popular. These studies enable researchers to infer taxa associations towards the understanding of coexistence, competition, and collaboration between microbes across time. Traditional metrics for association analysis, such as correlation, are limited due to the data characteristics of microbiome data (sparse, compositional, multivariate). Several network inference methods have been proposed, but have been largely unexplored in a longitudinal setting. We introduce LUPINE (LongitUdinal modelling with Partial least squares regression for NEtwork inference), a novel approach that leverages on conditional independence and low-dimensional data representation. This method is specifically designed to handle scenarios with small sample sizes and small number of time points. LUPINE is the first method of its kind to infer microbial networks across time, while considering information from all past time points. It . We validate LUPINE and its variant, LUPINE_single (for single time point analysis) in simulated data and three case studies, where we highlight LUPINE's ability to identify relevant taxa in each study context, across different experimental designs (mouse and human studies, with or without interventions, as short or long time courses). To detect changes in the networks across time, groups or in response to external disturbances, we used different metrics to compare the inferred networks. LUPINE is a simple yet innovative network inference methodology that is suitable for, but not limited to, analysing longitudinal microbiome data. The R code and data are publicly available for readers interested in applying these new methods to their studies.

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Next-generation probiotics: Health-promoting bacteria of the human gut

Golić,

Đokić,

Tolinački

et al. 2023

Arhiv za farmaciju

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In recent years, a vast number of human diseases have been correlated with gut microbiota dysbiosis. The development of modern methods in molecular microbiology, such as the culturomics approach, as well as various multi-omics methods like next generation sequencing, transcriptomics and metabolomics analysis, coupled with large data sets correlation analysis, enabled the cultivation and characterization of novel anaerobic hitherto uncultivated Next-Generation Probiotics. In addition, the results of host-microbe interactions studies helped to reveal the mechanisms involved in the beneficial effects of Next-Generation Probiotics. Eventually, the obtained data on Next-Generation Probiotics will help to broaden the scientific knowledge on these bacteria, in terms of both their safety and health-promoting effects, unravel opportunities for the development of novel therapeutic strategies for prevention and treatment of tumors, metabolic, neuropsychiatric and other diseases, with the aim of relieving the symptoms of the diseases and increasing the quality of life for patients and their families. So far, the best characterized probiotics of the new generation are Akkermansia muciniphila, Faecalibacterium prauznitzii and Bacteroides fragilis.

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Faecalibacterium prausnitzii Improves Lipid Metabolism Disorder and Insulin Resistance in Type 2 Diabetic Mice

Cited by 3 publications

References 43 publications

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

Microbial network inference for longitudinal microbiome studies with LUPINE

Next-generation probiotics: Health-promoting bacteria of the human gut

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