2019
DOI: 10.1002/iub.2224
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Abstract: Nutritional interventions, such as dietary or calorie restriction, are known to have a variety of health‐promoting effects. The most impressive are the direct effects on life expectancy, which have been reproduced in many animal models. A variety of dietary restriction protocols have been described, which differ either in their macronutrient composition or in the time window for consumption. Mechanistically, the effects of dietary restriction are mediated mainly through signaling pathways that have central rol… Show more

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Cited by 15 publications
(6 citation statements)
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References 115 publications
(252 reference statements)
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“…HydroZitLa significantly extended the lifespan of wild-type C. elegans up to 34% with no sign of toxicity, suggesting that the lifespan-extending effect of HydroZitLa was comparable with that of resveratrol. Dietary restriction is a known key mechanism in longevity 56 . The pharyngeal pumping rates compared between HydroZitLa worms and control worms were comparable, indicating that the lifespan extension by HydroZitLa was not a result of dietary restriction.…”
Section: Discussionmentioning
confidence: 99%
“…HydroZitLa significantly extended the lifespan of wild-type C. elegans up to 34% with no sign of toxicity, suggesting that the lifespan-extending effect of HydroZitLa was comparable with that of resveratrol. Dietary restriction is a known key mechanism in longevity 56 . The pharyngeal pumping rates compared between HydroZitLa worms and control worms were comparable, indicating that the lifespan extension by HydroZitLa was not a result of dietary restriction.…”
Section: Discussionmentioning
confidence: 99%
“…When nutrients are abundant, the downstream mediator denoted mechanistic target of rapamycin (mTOR; a protein kinase) is activated, and it is involved in several age-related disorders. Calorie restriction (CR) can mitigate this effect, and prolong life in some species ( Kapahi et al, 2017 ; von Frieling and Roeder, 2020 ). Thus, it is of considerable importance that Klotho inhibits the IGF-1/PI3K/Akt/mTOR pathway ( Kurosu et al, 2005 :; Xie et al, 2013 ).…”
Section: Klotho Functions Independent Of Fgf23mentioning
confidence: 99%
“…Dietary restriction is a critical mechanism that can also extend lifespan in different models, including C. elegans by mediating signalling pathways and maintaining the cellular energy balance [48]. A pharyngeal pumping assay was performed to confirm that the worms feed on S. asper and the lifespan extension was not because of dietary restriction.…”
Section: S Asper Can Reduce the Level Of Photoaging In C Elegansmentioning
confidence: 99%