Factors related to non-compliance with antihypertensive drug therapy

Jokisalo, Erkki; Kumpusalo, Esko; Enlund, Hannes; Halonen, Paavo; Takala, J

doi:10.1038/sj.jhh.1001448

Cited by 52 publications

(63 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although, this problem cannot be completely solved, there will be a cost-effective solution provided by clinical pharmacist to those patients according to their existing conditions. Some reports also indicated that pharmacist interventions were not likely to gain a statistically significant improvement in this outcome when medication adherence at baseline is already high (about 75%) (Chabot et al, 2003;Jokisalo et al, 2003), and in our study, low baseline medication adherence (47.5%) made it feasible for pharmaceutical intervention to get an obvious positive effect in this outcome and hence in treatment outcomes. And in the end, our percentage of low medication adherence accounted for 24.8%, which perfectly matched that in other studies.…”

Section: Discussionsupporting

confidence: 42%

“…The medication compliance of patients was poor previously due to some reasons, such as the complicated and hard-to-control disease course, the life-time dosing period, the economic condition of the patients as well as the irrational and complex drug use; thereby, most of the patients cannot be healed thoroughly (Jokisalo et al, 2003). This research on medication compliance of hypertensive patients was mainly conducted by pharmacist in the perspective of clinical medicine and clinical nursing.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of clinical pharmacists pharmaceutical care intervention to control hypertensive outpatients in China

Zhao¹,

Wang²,

Qin³

et al. 2012

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Hypertension is an increasingly common health problem that affects more than 1 billion people throughout the world. Antihypertensive drugs are the current pharmacotherapy of choice, however uncontrolled blood pressure (BP) accounts for 7.1 million deaths worldwide each year. Little is known about the efficacy of clinical pharmacist's pharmaceutical care on BP control and medication adherence. The aim of this study was to describe if pharmaceutical care could improve antihypertensive medication adherence and BP control, especially by clinical pharmacists recommendations. This report evaluates the clinical pharmacist interventions during a prospective randomized controlled trial. Out patients with essential hypertension were enrolled in a bimestrial follow-up during 6-month period study; patients were randomly allocated either intervention group (IG) or to control group (CG). Pharmacist interventions involved recommendations to physicians, educational and counseling directly to the patient. The main outcome measure for this analysis was the measure of systolic blood pressure (SBP), diastolic blood pressure (DBP), BP control and medication adherence using a validated questionnaire assessed at the baseline visit and the end of pharmaceutical care. Data from 278 patients were included and analyzed (139 in CG and 139 in IG). There were no significant differences (P < 0.05) in both groups at the baseline. Changes in drug therapy were recommended 192 times for IG patients, the majority of these, involved adding a new antihypertensive drug (42.7%); the largest numbers of pharmacist recommendations (39.6%) were made at the baseline visit. At the end, BP was controlled among significant patients more in IG (76.4%) than in CG (50.6%) (P = 0.0000). Significant lower SBP (-8.5 mmHg, P = 0.0001) and DBP (-4.7 mmHg, P = 0.0013) levels were observed in IG. Low medication adherence, there was also significantly difference between two groups at the end (24.8% versus 41.7%, P = 0.0014). Clinical pharmacist recommendations for alterations in pharmacotherapy intervention can significantly improve medication adherence and BP control in patients with hypertension. Clinical pharmacist recommendations can complement physicians in the management of hypertensive patients. Pharmacist interventions are effective in improving anti-hypertensive medication adherence and reducing systolic and diastolic blood pressure. Pharmacists can effectively participate in health education and promotion to improve blood pressure control.

show abstract

Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 99%

Effect of clinical pharmacists pharmaceutical care intervention to control hypertensive outpatients in China

Zhao¹,

Wang²,

Qin³

et al. 2012

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…33 Many studies did not report duration of hypertension to have a significant association with treatment compliance similar to our study. 12,34,35 There was no significant difference among patients with differing durations of disease, but compliance score was higher in those patients who had taken antihypertensive drugs for longer than 5 years in a cross-sectional study in Iran. 36 Compliance with a treatment regimen was positively correlated with duration of hypertension in study in Kingdom of Saudi Arabia.…”

Section: Discussionmentioning

confidence: 93%

Compliance to antihypertensive medication: a cross-sectional study in Aligarh

Khwaja

Ansari

Mehnaz

2017

Int J Community Med Public Health

View full text Add to dashboard Cite

Background: Hypertension is a global public health issue. Hypertensive heart disease is one of the top ten leading causes of death in the world. It was responsible for an estimated 1.1 million deaths worldwide in 2012. To prevent some of the complications of hypertension regular intake of the prescribed treatment in the form of medicines (pills) is essential. Poor compliance to anti-hypertensive therapy is usually associated with bad outcome of the disease and wastage of limited health care resources. With these viewpoints the study aimed to assess the level of compliance of hypertensive patients to their anti-hypertensive medications and to determine the socio-demographic correlates of compliance. Methods: This was community based cross sectional study conducted in urban and rural areas in Aligarh. A total of 350 hypertensive patients were selected using simple random sampling. A pretested semi-structured questionnaire was used. Compliance was measured by Morisky 8-item Medication Adherence scale. Analysis was done using proportions and Chi-square test. Results: The overall compliance of study population was 23.7%. It was found to be significantly associated with gender, education, social class and associated co morbidities. Education, higher social class and duration of hypertension were found to be the main facilitators to adherence. The barriers to adherence were cost of drug and more number of pills per day. Conclusions: Patient education, family counselling and social support networks should be strengthened in health promotion programs in order to enhance compliance of hypertensive patients with the therapeutic regimen and to improve their quality of life.

show abstract

“…[11][12][13][14][15][16] Determinants of poor BP control are multi-level. That is, previously identified factors that contribute to poor BP control have included physician-related factors, such as physician age, 17 willingness to accept high BP values 18 and so-called 'therapeutic inertia, ' 19 as well as patient-related factors, including age, 20,21 treatment adherence 22,23 and gender. [24][25][26] An area of clinical interest that has not received attention is whether or not the multi-level determinants of BP control are gender-specific.…”

Section: Introductionmentioning

confidence: 99%

Gender-specific, multi-level determinants of outcomes of antihypertensive treatment: a sub-analysis of the Belgian PREVIEW study

et al. 2010

View full text Add to dashboard Cite

Gender-specific determinants of blood pressure (BP) values and control have not been the focus of clinical hypertension research. The purpose of this analysis was to identify gender-specific and multi-level (physician and patient) determinants of BP values and predictors of uncontrolled BP. We completed a subgroup analysis comparing men and women who participated in the Belgian PREVIEW study of second-line treatment effectiveness of valsartan, applying two-level hierarchical modelling of 90-day BP values and guideline-defined BP control. In total, 1665 women and 1525 men were treated by 504 general practitioners. Fewer women than men reached systolic BP (SBP) (P ¼ 0.015) and combined BP targets at 90 days (P ¼ 0.007). More than 26% of the variance in 90-day SBP (intra-class correlation coefficient (ICC) ¼ 0.270) and diastolic BP (DBP) (ICC ¼ 0.262) was attributable to physicianlevel factors for men; the physician-level ICCs for SBP and DBP were 0.259 and 0.268, respectively, for women. Determinants of 90-day BP values and predictors of uncontrolled BP varied considerably by gender. Many of the multi-level determinants of BP by gender are amenable to intervention, and the remainder can serve as warning signs to clinicians that patients may remain vulnerable to poor outcomes associated with sub-optimal BP control.

show abstract

Factors related to non-compliance with antihypertensive drug therapy

Cited by 52 publications

References 20 publications

Effect of clinical pharmacists pharmaceutical care intervention to control hypertensive outpatients in China

Effect of clinical pharmacists pharmaceutical care intervention to control hypertensive outpatients in China

Compliance to antihypertensive medication: a cross-sectional study in Aligarh

Gender-specific, multi-level determinants of outcomes of antihypertensive treatment: a sub-analysis of the Belgian PREVIEW study

Contact Info

Product

Resources

About