Factors Predicting Long‐Term Mortality in Patients with Hypertrophic Cardiomyopathy

Bostan, Cem; Sinan, Ümit Yaşar; Canbolat, Polat; Abacı, Okay; Munipoglu, Sezer Karcier; Küçükoğlu, Serdar

doi:10.1111/echo.12537

Cited by 5 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LVEDD was largely affected by LV filling and contraction in HCM patients. Bostan et al [13] identified LVEDD was significantly different between survivors and nonsurvivors in HCM patients (P � 0.04). Nevertheless, LVEDD was not an independent predictor in the further analysis.…”

Section: Discussionmentioning

confidence: 90%

“…Both volume and pressure overload may lead to enlarged LA. Bostan et al reported that LAD ≥41 mm predicted 13-year mortality with a sensitivity of 82% and specificity of 78%, respectively [13]. Nistri et al [22] indicated LAD >48 mm was related to an HR of 1.9 for allcause mortality in HCM patients (P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Few data on pacing implantation in the whole HCM population or patients with nonobstructive hypertrophic cardiomyopathy (NOHCM) were analyzed. Left atrial diameter (LAD) is positively related to heart failure (HF) development, atrial fibrillation (AF), coronary heart disease, stroke, and all-cause mortality in the general population [12][13][14]. In a study of patients with HCM, left ventricular end-diastolic diameter (LVEDD) was found to be significantly correlated with mortality [13].…”

Section: Introductionmentioning

confidence: 99%

“…Left atrial diameter (LAD) is positively related to heart failure (HF) development, atrial fibrillation (AF), coronary heart disease, stroke, and all-cause mortality in the general population [12][13][14]. In a study of patients with HCM, left ventricular end-diastolic diameter (LVEDD) was found to be significantly correlated with mortality [13]. However, the impact of LVEDD, as well as LAD, on the all-cause mortality has not been well evaluated yet in HCM patients after the pacemaker implantation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Echocardiographic Predictors of All-Cause Mortality in Patients with Hypertrophic Cardiomyopathy following Pacemaker Implantation

Zhang

Hua

et al. 2020

Cardiology Research and Practice

View full text Add to dashboard Cite

Objectives. To examine the association between the echocardiographic parameters measured as left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) and long-term risk of all-cause mortality in adults with hypertrophic cardiomyopathy (HCM) following pacemaker implantation. Methods. A total of 94 adult patients with HCM who underwent pacemaker implantation from November 2002 to June 2013 in our Arrhythmia Center for symptomatic bradycardia and did not receive an implantable cardiac defibrillator (ICD) or cardiac resynchronization therapy (CRT) during follow-up were retrospectively extracted. Results. After careful examination of the medical records, we retrospectively evaluated the clinical characteristics of 74 patients with LAD records (58.1 ± 14.9 years) and 76 patients with LVEDD records (57.6 ± 15.2 years). Based on the receiver-operating characteristic (ROC) curve, the values of LAD = 44 mm and LVEDD = 43 mm were identified to predict the all-cause mortality. In the Kaplan–Meier survival, LAD ≥44 mm and LVEDD ≥43 mm were both significantly associated with all-cause mortality (log-rank test P<0.05). Cox regression analysis indicated that LAD ≥44 mm (HR 3.580; 95% CI = 1.055–12.148; P=0.041) was an independent predictor of all-cause mortality, while LVEDD ≥43 mm was not significantly associated with all-cause mortality. LVOTO was also significantly associated with all-cause mortality (HR = 0.166; 95% CI = 0.036–0.771; P=0.022). Conclusions. In HCM patients with pacemaker implantation, LAD ≥44 mm was an independent predictor of all-cause mortality.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Echocardiographic Predictors of All-Cause Mortality in Patients with Hypertrophic Cardiomyopathy following Pacemaker Implantation

Zhang

Hua

et al. 2020

Cardiology Research and Practice

View full text Add to dashboard Cite

show abstract

“…[ 6 ] found that in patients with dilated cardiomyopathy or heart failure (HF), LV dilatation was significantly associated with increased mortality [ 6 , 7 , 8 ]. In patients with hypertrophic cardiomyopathy (HCM), LVEDD was also a significant predictor of mortality [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Left Ventricular End-Diastolic Diameter and Long-Term Mortality in Patients with Coronary Artery Disease

Li¹,

Huang²,

Lü³

et al. 2023

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Left ventricular end-diastolic diameter (LVEDD) is a common parameter in echocardiography. Increased LVEDD is associated with left ventricular (LV) dysfunction. However, the association between LVEDD and all-cause mortality in patients with coronary artery disease (CAD) is uncertain. Methods: This study enrolled 33,147 patients with CAD who had undergone transthoracic echocardiography between January 2007 and December 2018 from the Cardiorenal Improvement study (NCT04407936). The patients were stratified into four groups based on the quartile of LVEDD (Quartile 1: LVEDD 43 mm, Quartile 2: 43 mm LVEDD 46 mm, Quartile 3: 46 mm LVEDD 51 mm, Quartile 4: LVEDD 51 mm) and were categorized into two groups (Quartile 1–3 versus Quartile 4). Survival curves were generated with the Kaplan-Meier analysis, and the differences between groups were assessed by log-rank test. Restricted cubic splines and cox proportional hazards models were used to investigate the association with LVEDD and all-cause mortality. Results: A total of 33,147 patients (average age: 63.0 10.6 years; 24.0% female) were included in the final analysis. In the average follow-up period of 5.2 years, a total of 4288 patients died. The mortality of the larger LVEDD group (Quartile 4) was significantly higher than the lower LVEDD groups (Quartile 1–3) (18.05% vs 11.15%, p 0.001). After adjusting for confounding factors, patients with the larger LVEDD (Quartile 4) had a 1.19-fold risk for all-cause mortality (95% CI: 1.09–1.30) compared with the lower quartile (Quartile 1–3). Conclusions: Enlarged LVEDD is an independent predictor of all-cause mortality in patients with CAD. LVEDD measurements may be helpful for risk stratification and providing therapeutic targets for the management of CAD patients.

show abstract

Left Ventricular Mass Quantification by Two-Dimensional Echocardiography in a Pediatric Population: Correlation with Cardiac Magnetic Resonance Imaging

et al. 2018

View full text Add to dashboard Cite

Factors Predicting Long‐Term Mortality in Patients with Hypertrophic Cardiomyopathy

Cited by 5 publications

References 30 publications

Echocardiographic Predictors of All-Cause Mortality in Patients with Hypertrophic Cardiomyopathy following Pacemaker Implantation

Echocardiographic Predictors of All-Cause Mortality in Patients with Hypertrophic Cardiomyopathy following Pacemaker Implantation

The Association between Left Ventricular End-Diastolic Diameter and Long-Term Mortality in Patients with Coronary Artery Disease

Left Ventricular Mass Quantification by Two-Dimensional Echocardiography in a Pediatric Population: Correlation with Cardiac Magnetic Resonance Imaging

Contact Info

Product

Resources

About