Factors influencing the steroid profile in doping control analysis

Mareck, Ute; Geyer, Hans; Opfermann, Georg; Thevis, Mario; Schänzer, Wilhelm

doi:10.1002/jms.1457

Cited by 237 publications

(264 citation statements)

References 63 publications

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“…The urinary steroid profile is composed of concentrations and ratios of various endogenously produced steroidal hormones, their precursors, and metabolites, including testosterone, epitestosterone, dihydrotestosterone, and androsterone. Any deviation of steroid concentrations in comparison to an individual's predetermined normal reference intervals will raise suspicion (55 ). Parent steroids and metabolites are usually measured by gas chromatography/combustion/isotoperatio mass spectrometry (IRMS) and associated techniques.…”

Section: Implications For Antidopingmentioning

confidence: 99%

Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

Musrap

Diamandis

2016

Clinical Chemistry

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BACKGROUND Since its discovery in the 1970s, prostate-specific antigen (PSA) has become widely known as a biomarker of prostate cancer in males but has often been overlooked in female malignancies. Although the serum concentration of PSA differs between men and women by about 1000-fold, studies have suggested that PSA concentrations drastically differ among healthy females and those who exhibit increased androgen production. CONTENT There have been reports of increased PSA expression in women exhibiting hyperandrogenic states, including polycystic ovary syndrome and hirsutism, as well as marked increases in a subset of breast cancer patients. These findings have not only revealed the remarkable diagnostic potential of PSA in a diverse range of clinical conditions but also point to its potential of becoming a useful biomarker of steroid hormone doping among female athletes. Recently, highly sensitive assays that can measure PSA at low limits of detection have been developed, which will aid in the discrimination of PSA between these different conditions. SUMMARY The overall aim of this review is to revisit the expression of PSA in hormonally-regulated tissues and in female malignancies, and to demonstrate how the regulation of PSA permits its use in antidoping initiatives.

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Section: Implications For Antidopingmentioning

confidence: 99%

Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

Musrap

Diamandis

2016

Clinical Chemistry

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“…In particular, the urinary steroid profile, which is mainly based on testosterone, reflects the metabolic pathways of androgenic compounds and is essential for the diagnosis of diseases related to steroid secretion (Mareck et al 2008). Recently, MS-based metabolomics was applied to directly analyse and quantify major urinary metabolites as markers of exogenous steroid administration in routine doping controls (Badoud et al 2011).…”

Section: Metabolomics For the Definition Of 'Normal'mentioning

confidence: 99%

Perspectives for metabolomics in testosterone replacement therapy

Häring

2012

Journal of Endocrinology

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Testosterone is the major circulating androgen in men but exhibits an age-related decline in the ageing male. Late-onset hypogonadism or androgen deficiency syndrome (ADS) is a ‘syndromic’ disorder including both a persistent low testosterone serum concentration and major clinical symptoms, including erectile dysfunction, low libido, decreased muscle mass and strength, increased body fat, decreased vitality or depressed mood. Given its unspecific symptoms, treatment goals and monitoring parameters, this review will outline the various uncertainties concerning the diagnosis, therapy and monitoring of ADS to date. Literature was identified primarily through searches for specific investigators in the PubMed database. No date or language limits were applied in the literature search for the present review. The current state of research, showing that metabolomics is starting to have an impact not only on disease diagnosis and prognosis but also on drug treatment efficacy and safety monitoring, will be presented, and the application of metabolomics to improve the clinical management of ADS will be discussed. Finally, the scientific opportunities presented by metabolomics and other -omics as novel and promising tools for biomarker discovery and individualised testosterone replacement therapy in men will be explored.

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“…The other solution allowing efficient detection of testosterone abuse in people is a longitudinal and retrospective evaluation of doping control samples in terms of steroid profiles which would enable the detection of abnormal alternations that trigger confirmatory analyses [18]. Application of this approach routinely could also result in limitation of number of samples, which should be analyzed by using the IRMS technique.…”

Section: Fig 1 Histogram Of T/e Ratio Values In Urine Samples Testementioning

confidence: 99%

Some aspects concerning modifications of the List of Prohibited Substances and Methods in sport

Pokrywka¹,

Kwiatkowska²,

Kaliszewski³

et al. 2010

Biol Sport

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Factors influencing the steroid profile in doping control analysis

Cited by 237 publications

References 63 publications

Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

Perspectives for metabolomics in testosterone replacement therapy

Some aspects concerning modifications of the List of Prohibited Substances and Methods in sport

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