Factors influencing survival of patients with adenoid cystic carcinoma of the salivary glands

Minor Salivary Gland Neoplasms

“…19 Management of other types of salivary neoplasms that were not mentioned in our study is more challenging because of their relative infrequency, inconsistent classification, and variable biologic behavior. 20,21 A better understanding of the histogenesis of neoplasms of the salivary glands by further studies about ultrastructural and molecular analysis may provide significant information about their behavior and therapeutic response. 22 …”

Minor Salivary Gland Neoplasms

“…19 Management of other types of salivary neoplasms that were not mentioned in our study is more challenging because of their relative infrequency, inconsistent classification, and variable biologic behavior. 20,21 A better understanding of the histogenesis of neoplasms of the salivary glands by further studies about ultrastructural and molecular analysis may provide significant information about their behavior and therapeutic response. 22 …”

Adenoid cystic carcinoma of the sublingual salivary gland in a 16-year-old female – report of a case and review of the literature

“…Local failures and metastases may not become evident for 10 years or more after initial treatment and the clinical course is characterized by repeated surgical interventions (Seaver and Keuhn, 1979). Survival rates differ considerably between reported series with rates at five, 10 and 15 years of 37-75 per cent, nine to 28 per cent and three to 20 per cent respectively (Conley and Dingman, 1974;Seaver and Keuhn, 1979;Nascimento et al, 1986;Ampil and Misra, 1987). The prognosis of adenoid cystic carcinoma is influenced by a variety of factors including the histological type, clinical stage, site and adequacy of primary treatment.…”

“…Patients with metastatic disease may survive for up to seven years without treatment. (Andersen et al, 1991) Ampil and Misra (1987) consider that almost all patients eventually have recurrence.…”

“…Adenoid cystic carcinoma is radiosensitive but it is difficult to justify radiotherapy in cases where complete surgical resection of tumour has been achieved as many will remain disease-free in the long-term (Elkon et al, 1980;Ampil and Misra, 1987;Andersen et al, 1991). Postoperative radiotherapy to the neck is probably only required for those patients with proven nodal disease (Armstrong et al, 1991) or for those with incomplete excision margins (Ampil and Misra, 1987). Radiotherapy alone achieves a local control rate of 37 per cent at five years compared to 86 per cent obtained with surgery and radiotherapy combined where the excision is incomplete (Cowie and Pointon, 1984).…”

“…Simpson et al (1984) consider that patients in whom local recurrence develops after surgery should be treated vigorously with radiotherapy as disease control in these cases may be as good as those who were treated with radiotherapy at the time of diagnosis. In the long-term the major threat to this patient's survival is likely to be metastatic disease (Spiro et al, 1974;Ampil and Misra, 1987).…”

Minor Salivary Gland Neoplasms

“…19 Management of other types of salivary neoplasms that were not mentioned in our study is more challenging because of their relative infrequency, inconsistent classification, and variable biologic behavior. 20,21 A better understanding of the histogenesis of neoplasms of the salivary glands by further studies about ultrastructural and molecular analysis may provide significant information about their behavior and therapeutic response. 22 …”

Adenoid cystic carcinoma of the sublingual salivary gland in a 16-year-old female – report of a case and review of the literature

“…Local failures and metastases may not become evident for 10 years or more after initial treatment and the clinical course is characterized by repeated surgical interventions (Seaver and Keuhn, 1979). Survival rates differ considerably between reported series with rates at five, 10 and 15 years of 37-75 per cent, nine to 28 per cent and three to 20 per cent respectively (Conley and Dingman, 1974;Seaver and Keuhn, 1979;Nascimento et al, 1986;Ampil and Misra, 1987). The prognosis of adenoid cystic carcinoma is influenced by a variety of factors including the histological type, clinical stage, site and adequacy of primary treatment.…”

“…Patients with metastatic disease may survive for up to seven years without treatment. (Andersen et al, 1991) Ampil and Misra (1987) consider that almost all patients eventually have recurrence.…”

“…Adenoid cystic carcinoma is radiosensitive but it is difficult to justify radiotherapy in cases where complete surgical resection of tumour has been achieved as many will remain disease-free in the long-term (Elkon et al, 1980;Ampil and Misra, 1987;Andersen et al, 1991). Postoperative radiotherapy to the neck is probably only required for those patients with proven nodal disease (Armstrong et al, 1991) or for those with incomplete excision margins (Ampil and Misra, 1987). Radiotherapy alone achieves a local control rate of 37 per cent at five years compared to 86 per cent obtained with surgery and radiotherapy combined where the excision is incomplete (Cowie and Pointon, 1984).…”

“…Simpson et al (1984) consider that patients in whom local recurrence develops after surgery should be treated vigorously with radiotherapy as disease control in these cases may be as good as those who were treated with radiotherapy at the time of diagnosis. In the long-term the major threat to this patient's survival is likely to be metastatic disease (Spiro et al, 1974;Ampil and Misra, 1987).…”

Minor Salivary Gland Neoplasms

“…19 Management of other types of salivary neoplasms that were not mentioned in our study is more challenging because of their relative infrequency, inconsistent classification, and variable biologic behavior. 20,21 A better understanding of the histogenesis of neoplasms of the salivary glands by further studies about ultrastructural and molecular analysis may provide significant information about their behavior and therapeutic response. 22 …”

Adenoid cystic carcinoma of the sublingual salivary gland in a 16-year-old female – report of a case and review of the literature

“…Local failures and metastases may not become evident for 10 years or more after initial treatment and the clinical course is characterized by repeated surgical interventions (Seaver and Keuhn, 1979). Survival rates differ considerably between reported series with rates at five, 10 and 15 years of 37-75 per cent, nine to 28 per cent and three to 20 per cent respectively (Conley and Dingman, 1974;Seaver and Keuhn, 1979;Nascimento et al, 1986;Ampil and Misra, 1987). The prognosis of adenoid cystic carcinoma is influenced by a variety of factors including the histological type, clinical stage, site and adequacy of primary treatment.…”

“…Patients with metastatic disease may survive for up to seven years without treatment. (Andersen et al, 1991) Ampil and Misra (1987) consider that almost all patients eventually have recurrence.…”

“…Adenoid cystic carcinoma is radiosensitive but it is difficult to justify radiotherapy in cases where complete surgical resection of tumour has been achieved as many will remain disease-free in the long-term (Elkon et al, 1980;Ampil and Misra, 1987;Andersen et al, 1991). Postoperative radiotherapy to the neck is probably only required for those patients with proven nodal disease (Armstrong et al, 1991) or for those with incomplete excision margins (Ampil and Misra, 1987). Radiotherapy alone achieves a local control rate of 37 per cent at five years compared to 86 per cent obtained with surgery and radiotherapy combined where the excision is incomplete (Cowie and Pointon, 1984).…”

“…Simpson et al (1984) consider that patients in whom local recurrence develops after surgery should be treated vigorously with radiotherapy as disease control in these cases may be as good as those who were treated with radiotherapy at the time of diagnosis. In the long-term the major threat to this patient's survival is likely to be metastatic disease (Spiro et al, 1974;Ampil and Misra, 1987).…”