Factors Associated with Tuberculosis Treatment Default in an Endemic Area of the Brazilian Amazon: A Case Control-Study

Garrido, Marlucia da Silva; Penna, Maria Lúcia Fernandes; Perez-Porcuna, Tomas M; Souza, Alexandra B.; Marreiro, Leni da Silva; Albuquerque, Bernardino Cláudio de; Martínez-Espinosa, Flor Ernestina; Bührer-Sékula, Samira

doi:10.1371/journal.pone.0039134

Cited by 61 publications

(65 citation statements)

References 20 publications

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“…As a result, both culture and smear had low positive predictive value (PPV) ranging from 9 to 18% in predicting poor outcome. In contrast, negative predictive values (NPV) were high (at least 93%), indicating a negative sputum test result during any month of treatment makes relapse or failure unlikely (23). In our study, 3 rd month microscopy positivity was associated with a five-fold increase in odds for adverse treatment outcome.…”

Section: Discussioncontrasting

confidence: 64%

A Retrospective Case-Control Study, Factors Affecting Treatment Outcomes for Pulmonary Tuberculosis in İstanbul, Turkey

Babalik¹,

Kılıçaslan²,

Kızıltaş³

et al. 2013

Balkan Med J

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Section: Discussioncontrasting

confidence: 64%

A Retrospective Case-Control Study, Factors Affecting Treatment Outcomes for Pulmonary Tuberculosis in İstanbul, Turkey

Babalik¹,

Kılıçaslan²,

Kızıltaş³

et al. 2013

Balkan Med J

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“…As observed during this study period, treatment dropout rates remained stable, at approximately 10%, in Amazonas. Garrido et al (21) previously reported treatment dropout, HIV positivity, alcoholism, low educational level, and the presence of other comorbidities as risk factors associated with TB treatment dropout in Amazonas. This group also reported that advanced age and DOT were protective factors (22) .…”

Section: Introductionmentioning

confidence: 99%

Temporal distribution of tuberculosis in the State of Amazonas, Brazil

Garrido

Bührer-Sékula

Souza

et al. 2015

Rev. Soc. Bras. Med. Trop.

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63www.scielo.br/rsbmt I www.rsbmt.org.br Revista da Sociedade Brasileira de Medicina Tropical 48(Suppl I):63-69, 2015http://dx.doi. org/10.1590/0037-8682-0055-2014 Review Article ABSTRACT Tuberculosis (TB) is one of the infectious diseases that contributes most to the morbidity and mortality of millions of people worldwide. Brazil is one of 22 countries that accounts for 80% of the tuberculosis global burden. The highest incidence rates in Brazil occur in the States of Amazonas and Rio de Janeiro. The aim of this study was to describe the temporal distribution of TB in the State of Amazonas. Between 2001 and 2011, 28,198 cases of tuberculosis were reported in Amazonas, distributed among 62 municipalities, with the capital Manaus reporting the highest (68.7%) concentration of cases. Tuberculosis was more prevalent among males (59.3%) aged 15 to 34 years old (45.5%), whose race/color was predominantly pardo (64.7%) and who had pulmonary TB (84.3%). During this period, 81 cases of multidrug-resistant TB were registered, of which the highest concentration was reported from 2008 onward (p = 0.002). The municipalities with the largest numbers of indigenous individuals affected were São Gabriel da Cachoeira (93%), Itamarati (78.1%), and Santa Isabel do Rio Negro (70.1%). The future outlook for this region includes strengthening the TB control at the primary care level, by expanding diagnostic capabilities, access to treatment, research projects developed in collaboration with the Dr. Heitor Vieira Dourado Tropical Medicine Foundation [Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)] and fi nancing institutions, such as the project for the expansion of the Clinical Research Center and the creation of a hospital ward for individuals with transmissible respiratory diseases, including TB.

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“…15 New finding in this study was presence of a significant association (p=0.037) between education and place where the diagnosis was first done, majority of them were illiterates and majority of them were diagnosed first at government general hospital (Table 2). …”

Section: New Findings In the Studymentioning

confidence: 54%

A socio-demographic study of the “loss to follow–up in TB cases under DOTS” in and around tertiary teaching care hospital

Pasha

Fatima

Gopichand

et al. 2017

Int J Community Med Public Health

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INTRODUCTIONAs per WHO data India has 24 per cent of world's TB cases compared to the South-East Asian countries that account for 60 per cent of total cases worldwide.1 Inspite of TB being discovered more than 100 years ago and implementation of RNTCP in 1962, still there are loss to follow up cases of TB. There are many reasons for this, one of them being lack of education, low socio-economic status that results in less patient compliance. This made me to take up this study to know the demographic profile of loss to follow up cases.India is the country with the highest burden of TB.1 On the basis of prevalence rate, India ranks 14th among 22 high TB burden countries globally.3 One-fourth of the global incident TB cases occur in India annually. As per WHO Global TB Report, 2015, out of the estimated global annual incidence of 9.6 million TB cases, 2.2 million were estimated to have occurred in India. We have achieved the TB Millennium Development Goals ABSTRACT Background: India had 2.6 million cases of Tuberculosis as per the latest count and ranks 14th among 22 high TB burden countries globally. Loss to follow-up is a TB patient who did not start treatment or whose treatment was interrupted for 2 consecutive months or more. Knowing the demographic profile and reasons for non-adherence to treatment among the loss to follow up TB cases helps in prevention of infection source, development of resistant strains and also helps in reducing relapse rate and mortality, which helps in achieving the end TB strategy. Methods: The aim of this study was to know the socio-demographic profile of "loss to follow up in TB cases under DOTS" in and around tertiary teaching care hospital. A retrospective analytical study was done after getting a sample size i.e.79 cases from the register obtained from Tuberculosis unit, Government Hospital, Nandyal. Results: Out of 79 cases, 45 (57%) belonged to upper lower class (IV), 15 (19%) belonged to lower class (V), 14 (17.7%) belonged to lower middle class (III), 5 (6.3%) belonged to upper middle class, according to modified Kuppuswamy classification. Conclusions:The study showed that most of the patients belonged to upper lower class and there was significant association between (a) socio-economic status and symptoms appeared, (b) socio-economic status and investigations done, (c) socio-economic status and the person who diagnosed first, (d)socio-economic status and under whose supervision treatment was taken.

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Factors Associated with Tuberculosis Treatment Default in an Endemic Area of the Brazilian Amazon: A Case Control-Study

Cited by 61 publications

References 20 publications

A Retrospective Case-Control Study, Factors Affecting Treatment Outcomes for Pulmonary Tuberculosis in İstanbul, Turkey

A Retrospective Case-Control Study, Factors Affecting Treatment Outcomes for Pulmonary Tuberculosis in İstanbul, Turkey

Temporal distribution of tuberculosis in the State of Amazonas, Brazil

A socio-demographic study of the “loss to follow–up in TB cases under DOTS” in and around tertiary teaching care hospital

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