Factors associated with the elevated percentage of CD4CD69 T cells in maintained hemodialysis patients

Chen, Rongyi; Fei, Xiang; Hu, Jiayue; Cao, Xuesen; Tan, Xiao; Jia, Ping; Zhang, Ting; Song, Nana; Fang, Yi; Ding, Xiaoqiang; Zou, Jianzhou

doi:10.1080/0886022x.2017.1349672

Cited by 9 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism underlying the link between low-eGFR Â DII and BMD was still unknown. We speculated that the different effects of the pro-inflammatory diet on BMD independent of renal function may be confounded by a deterioration in the pro-inflammatory milieu and a concomitantly impaired immune system with CKD progression [40,41].…”

Section: Discussionmentioning

confidence: 99%

The relationship between dietary inflammatory index and bone mineral density in CKD patients

Wu,

Li,

et al. 2023

Ther Apher Dial

View full text Add to dashboard Cite

IntroductionChronic systemic inflammation was proposed as a critical factor in the development of osteoporosis. We aim to investigate the effect of the DII on bone mineral density (BMD) in CKD patients.Methods2276 participants from NHANES were enrolled. The DII score was calculated based on a single 24‐h dietary recall. Total BMD was measured using Dual‐energy x‐ray absorptiometry. A multiple‐stepwise linear regression model was used to determine associations between BMD and DII in CKD patients.ResultsWhen DII >0.35, a negative correlation was obtained between DII and BMD (all β = −0.008 and p < 0.05). In subgroup analysis, BMD levels decreased across increasing tertiles of the DII for patients with non‐osteoporosis, postmenopause, and low eGFR (p for trend ≤0.01).ConclusionHigher consumption of pro‐inflammatory diet correlates negatively with the BMD levels in CKD patients.

show abstract

Section: Discussionmentioning

confidence: 99%

The relationship between dietary inflammatory index and bone mineral density in CKD patients

Wu,

Li,

et al. 2023

Ther Apher Dial

View full text Add to dashboard Cite

show abstract

“…Furthermore, PLM200 showed a significant elevation of 31.26% at only CD69 + in CD4 + &CD69 + (CD69 that represents the initial activity of T cell) in PEC (Fig. 5 ) [ 38 ]. These results clearly indicate that PLM is potent as immune-boosting material because it caused the activation of T subtypes in the thymus, PBMC, and PEC.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium

Shin

Lee

et al. 2021

BMC Complement Med Ther

View full text Add to dashboard Cite

Background The present study extensively aimed to evaluate the underlying mechanism of the immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium (PLM). Methods To assess whether PLM influences the production of markers related to inflammation, Lipopolysaccharide (LPS)-stimulated RAW264.7 cells were treated with PLM (50, 100, 200, and 500 μg/mL). Splenocyte, thymus, peritoneal exudate cells (PEC), and peripheral blood mononuclear cells (PBMC) were isolated from the Balb/c mice treated with Korean red ginseng or PLM once a day for 5 weeks. Moreover, all mice except normal mice were stimulated with 10% proteose peptone (PP) treated 3 days before the sacrifice and 2% starch treated 2 days before the sacrifice. Subsequently, the cytotropic substance was evaluated by using flow cytometry analysis and ELISA assay. Results PLM200 treatment significantly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and inhibited the release of proinflammatory cytokines such as interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α dose-dependently in the LPS-stimulated RAW264.7 cells. PLM200 supplementation showed a significant increase in IL-2, IL-12, and interferon (IFN)-γ production and upregulated the ratio of IFN-γ (T-helper type 1, Th1) to IL-4 (T-helper type 2, Th2) in splenocytes. After PLM200 treatment, the significant elevation of CD4+CD25+, CD4+&CD8+, and CD4+CD69+ treatment were detected in thymus. Moreover, CD4+ and CD4+CD69+ in PBMC and CD69+ in PEC were also shown in a significant increase. Conclusions Taken together, these results showed an immunomodulatory effect of PLM about an elevated INF-γ/IL4 ratio, as an index of Th1/Th2, as well as the anti-inflammatory effect in the LPS-stimulated RAW264.7 cells. Therefore, our findings demonstrate that PLM possesses immunostimulatory and anti-inflammatory effects.

show abstract

“…In addition, expression of CD28 (a coreceptor for Tcell activation) and the T-cell activation marker CD69 are reduced in patients on hemodialysis as compared with healthy controls, further suggestive of impaired T-cell function in these patients. 80,81 The complexities of the underlying disease pathology associated with CKD likely have divergent effects on T-cell function; however, the hemodialysis procedure itself also affects T-cell activation and the production of inflammatory cytokines. 68,82 The proportion of CD4þ T cells undergoing apoptosis is significantly higher immediately after the hemodialysis procedure than before, 68 while the duration of hemodialysis dependency has been shown to correlate with an increased percentage of apoptotic CD3þ and CD4þ T cells.…”

Section: Impaired T-cell Immunity In Patients On Hemodialysismentioning

confidence: 99%