Factors associated with serum thyroglobulin in a Ukrainian cohort exposed to iodine-131 from the accident at the Chernobyl Nuclear Plant

Peters, Kamau O.; Тronko, М.D.; Hatch, Maureen; Oliynyk, Valeriy; Terekhova, G. M.; Pfeiffer, Ruth M.; Shpak, Victor; McConnell, Robert J.; Drozdovitch, Vladimir; Little, Mark P.; Zablotska, Lydia B.; Mabuchi, Kiyóhiko; Brenner, Alina V.; Cahoon, Elizabeth K.

doi:10.1016/j.envres.2017.04.014

Cited by 9 publications

(7 citation statements)

References 58 publications

(90 reference statements)

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“… 9 – 15 , 48 – 58 . Furthermore, CLIP2 and TG were the only previously suggested biomarkers that were also identified in the present study 11 , 12 , 16 , 53 , 54 . The CLIP2 protein was detected in plasma in the nine month groups, indicating that the time of exposure to the endpoint has a profound effect on whether certain genes or proteins can be detected.…”

Section: Discussionsupporting

confidence: 76%

Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I

Larsson

Rudqvist

Spetz

et al. 2022

Sci Rep

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Abstract131I is used clinically for therapy, and may be released during nuclear accidents. After the Chernobyl accident papillary thyroid carcinoma incidence increased in children, but not adults. The aims of this study were to compare 131I irradiation-dependent differences in RNA and protein expression in the thyroid and plasma of young and adult rats, and identify potential age-dependent biomarkers for 131I exposure. Twelve young (5 weeks) and twelve adult Sprague Dawley rats (17 weeks) were i.v. injected with 50 kBq 131I (absorbed dose to thyroid = 0.1 Gy), and sixteen unexposed age-matched rats were used as controls. The rats were killed 3–9 months after administration. Microarray analysis was performed using RNA from thyroid samples, while LC–MS/MS analysis was performed on proteins extracted from thyroid tissue and plasma. Canonical pathways, biological functions and upstream regulators were analysed for the identified transcripts and proteins. Distinct age-dependent differences in gene and protein expression were observed. Novel biomarkers for thyroid 131I exposure were identified: (PTH), age-dependent dose response (CA1, FTL1, PVALB (youngsters) and HSPB6 (adults)), thyroid function (Vegfb (adults)). Further validation using clinical samples are needed to explore the role of the identified biomarkers.

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Section: Discussionsupporting

confidence: 76%

Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I

Larsson

Rudqvist

Spetz

et al. 2022

Sci Rep

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“…In accord with our results, serum Tg was found to be significantly related to the development of thyroid abnormalities and nodules in a population-based cohort assembled in Belarus following the Chernobyl nuclear accident (Cahoon et al 2013). Additionally, data from a recent publication, which evaluated 10,430 individuals who were living in Ukraine and were under 18 years of age at the time of the Chernobyl accident, also confirmed higher mean and median Tg levels in participants with abnormal thyroid glands (Peters et al 2017). Early data from the Fukushima area do not suggest an association between the baseline Tg levels and either benign or malignant thyroid nodules in the first few years after the accidental radiation exposure, but the long-term follow-up studies are not yet available (Suzuki et al 2016b).…”

Section: Discussionsupporting

confidence: 89%

Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children

Shulan¹,

Vydro²,

Schneider³

et al. 2018

Endocrine-Related Cancer

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With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid nodules and cancer in a cohort of radiation-exposed children. 764 subjects who were irradiated in the neck area as children were examined and followed for up to 25 years. All subjects underwent a clinical examination, measurements of thyrotropin, thyroglobulin levels and thyroid imaging. At baseline, 216 subjects had thyroid nodules and 548 did not. Of those with nodules, 176 underwent surgery with 55 confirmed thyroid cancers. During the follow-up, 147 subjects developed thyroid nodules including 22 with thyroid cancer. Thyroglobulin levels were higher in subjects with prevalent thyroid nodules (26.1 ng/mL vs 9.37 ng/mL; < 0.001) and in those who had an initial normal examination but later developed thyroid nodules (11.2 ng/mL vs 8.87 ng/mL; = 0.017). There was no relationship between baseline thyrotropin levels and the prevalent presence or absence of thyroid nodules, whether a prevalent neoplasm was benign or malignant, subsequent development of thyroid nodules during follow-up or whether an incident nodule was benign or malignant. In conclusion, in radiation-exposed children, higher thyroglobulin levels indicated an increased risk of developing thyroid nodules but did not differentiate between benign and malignant neoplasms. There was no association between the baseline TSH level and the risk of developing thyroid nodules or cancer.

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“…Проте історично так склалося, що система охорони здоров'я при створенні була націлена не на профілактику захворювань дорослих і дітей, а в основному на їх лікування. Обмеженість лікарняно-профілактичних та санітарно-профілактичних закладів не дозволяє охопити все населення України профілактикою захворювань, у тому числі й недуг, пов'язаних із йодним дефіцитом [14].…”

Section: вступunclassified

“…Заходи первинної та вторинної профілактики, а також лікування початкових змін при йододефіцитних станах є досить простими та доступними, завдяки яким (провадження профілактичних програм на державному рівні щодо обов'язкового йодування солі) до 2017 року в більшості країн проблема дефіциту йоду вирішена. Однак до сьогодні в 19 країнах, серед яких і Україна, питання недостатнього споживання йоду залишається актуальним [14].…”

Section: вступunclassified

Соціально-Гігієнічна Характеристика Дітей Ізйододефіцитного Регіону

Sorokman¹,

Bachu²

2021

Mìžnarodnij endokrinologìčnij žurnal

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Background. Determining the social and hygienic patterns of children’s health is an important scientific and methodological task of pediatrics, the solution of which makes it possible to manage health processes. Natural factors that affect health include iodine deficiency in environmental components. Nowadays in 19 countries, including Ukraine, the issue of iodine deficiency remains relevant. The purpose was to analyze social and hygienic factors in schoolchildren from the iodine deficiency region. Materials and methods. A survey of schoolchildren (n = 1,973) and their parents (n = 655) was conducted, we have examined 397 children aged 10–12 years from 7 districts of the Chernivtsi region. The concentration of inorganic iodine in a single urine portion was determined in 197 children, salt samples were tested using a rapid test. Results. In 2017, 56.1 % of parents-respondents did not know about the problem of iodine deficiency, and in 2019 — 28.2 %. Out of 397 salt samples taken from households, the presence of iodine was found in 133 (33.5 %) and 45 (41.3 %) of 109 samples taken from trade establishments. Of 509 samples labeled as iodized salt, only 35 % contained iodine and 65 % did not meet the requirements. The hygienic assessment of the balance of children’s diet revealed significant violations that may contribute to the development of iodine deficiency. Of 1,973 respondents, 15.7 % eat natural products. A disharmonious style of family upbringing dominated, which changes the emotional and mental state of a child. The median ioduria in the examined population is in general 58.1 ± 3.2 μg/l, the frequency of goiter among prepubertal children of Bukovinian region is 17.2 %. Two or more concomitant diseases, asthenic, neurotic and affective disorders were detected in 75.5 % of schoolchildren. Conclusions. Low public awareness, sale of iodized salt on the consumer market, which does not meet hygienic standards for iodine content, low motivation to use iodized salt on the background of iodine deficiency, even mild, are additional risk factors for iodine deficiency in schoolchildren of Chernivtsi region.

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Factors associated with serum thyroglobulin in a Ukrainian cohort exposed to iodine-131 from the accident at the Chernobyl Nuclear Plant

Cited by 9 publications

References 58 publications

Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I

Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I

Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children

Соціально-Гігієнічна Характеристика Дітей Ізйододефіцитного Регіону

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