Factors Associated With Receipt of Two Doses of Varicella Vaccine Among Adolescents in the United States

Kawai, Kosuke; O’Brien, Megan A.; Conway, James H.; Marshall, Gary S.; Kuter, Barbara J.

doi:10.1097/inf.0b013e31827f4c3c

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…In the United States, higher maternal educational levels positively correlated with varicella vaccination. 46 Similarly, families with better parental educational attainments and higher family income showed greater vaccination rates in Turkey and Taiwan. 34 , 47 Promoting parental knowledge on vaccination is a key factor in improving immunization rates, especially in families with lower educational backgrounds and from cities with low socioeconomic ranking, as observed in Israel.…”

Section: Discussionmentioning

confidence: 98%

Parental Attitudes and Factors Associated With Varicella Vaccination in Preschool and Schoolchildren in Hong Kong

Tam¹,

Chan

et al. 2015

Medicine

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This study investigates parental attitudes and factors associated with varicella vaccination among preschool and schoolchildren prior to introduction of the vaccine into Hong Kong's universal Childhood Immunization Program.Fourteen kindergartens and 5 primary schools in Hong Kong were randomly selected in 2013. Parents of the students were invited to answer the self-administered questionnaires. Acquired information included demographic characteristics and socioeconomic statuses of families, children's history of chickenpox infection and vaccination, and reasons for getting children vaccinated. Logistic regression was applied to examine the factors associated with vaccination.From the 3484 completed questionnaires, the calculated rates of varicella infection and vaccination were 20.7% and 69.0%, respectively. Barriers to vaccination included parental uncertainties about vaccine effectiveness, lack of recommendation from the government, and concerns on adverse effects. Overall, 71.8%, 69.0%, and 45.7% of the parents rated family doctors, specialists, and the government, respectively, as very important motivators of vaccination. Higher parental educational level and family income, better perceived knowledge of varicella and chance of infection, discussion with a family doctor, and positive health belief towards vaccination were associated with vaccination (all P < 0.05).The rate of vaccination in Hong Kong was higher than that of some other countries that also did not include the vaccine in their routine immunization programs. More positive parental attitudes, higher socioeconomic status, and discussion with a family doctor are associated with greater vaccination rates. The important roles that health professionals and the government play in promoting varicella vaccination were emphasized.

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Section: Discussionmentioning

confidence: 98%

Parental Attitudes and Factors Associated With Varicella Vaccination in Preschool and Schoolchildren in Hong Kong

Tam¹,

Chan

et al. 2015

Medicine

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“…The vaccination coverage rate is affected by various factors such as socioeconomic status, parent education background, access to private health insurance, frequency of health-care visits, vaccination funding, and public school entrance requirements. 13 On a questionnaire assessing parental awareness regarding vaccination in Japan, the reasons most frequently given for not receiving a vaccination were: the cost of voluntary vaccination, lack of knowledge about vaccination, misunderstandings regarding adverse events, and time required for vaccination. 11,14 In a survey conducted prior to national funding for varicella vaccination in Australia, the most common reasons for parental refusal of the varicella vaccine was the perceived cost and the misperception that varicella was a mild disease.…”

Section: Discussionmentioning

confidence: 99%

Trends in varicella and mumps vaccination rates in children under 3 years of age in a tertiary children's hospital in Japan

Morikawa

Morino

Ito

et al. 2019

Pediatrics International

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Background In Japan, the voluntary vaccination rate is not known accurately. Although two doses of the measles and rubella vaccines have been part of the universal vaccine program since 2006, the varicella vaccine was added in October 2014 while the mumps vaccine still remains voluntary. The aim of this study was to evaluate trends in the live measles, rubella, varicella and mumps vaccination rates in Japan. Methods This retrospective cohort study was conducted at Tokyo Metropolitan Children's Medical Center between October 2012 and December 2016. Patients aged 1–2 years who were admitted to the Department of General Pediatrics were enrolled. The trend in the vaccination rate against measles, rubella, varicella, and mumps was examined. Results The measles and rubella vaccination rate was 80–90%. The varicella vaccination rate in the second quarter of 2012, the third quarter of 2014, and the fourth quarter of 2016 was 34.6%, 67.1%, and 80.7%, respectively. The mumps vaccination rate in the second quarter of 2012, the third quarter of 2014, and the fourth quarter of 2016 was 27.6%, 59.5%, and 61.8%, respectively. Conclusions The varicella and mumps vaccination rate improved until 2014 despite the fact that they were voluntary vaccinations. After varicella vaccination was added to the universal vaccination program, the varicella vaccination rate continued to improve. The mumps vaccination, which was not included, failed to improve, suggesting that the universal vaccination program contributed to increasing the uptake of the vaccines it includes.

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“…Many studies [17][18][19][20][21][22][23] showed that the 2-dose recommendation for varicella vaccine significantly decreased varicella incidence, and Kuter et al 14 reported that the second dose improved the humoral and cellular immune responses that promote protection against VZV. Their post-licensure clinical trial also found that the risk for breakthrough cases was 3.3-fold higher in the one-dose group than in the 2-dose group.…”

Section: Discussionmentioning

confidence: 99%

Immunogenicity and safety of different schedules of 2-dose varicella vaccination in China

Deng

Xu²,

Yan

et al. 2016

Human Vaccines & Immunotherapeutics

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We evaluated the safety and immunogenicity of different time intervals for a second dose of varicella vaccine in children in Zhejiang Province, China. Participants had all received a first dose of varicella vaccine and were assigned to 4 groups according to age (2-7 years). A second dose of live attenuated varicella vaccine was administered 1 month, 1 year, 3 years, or 5 years after the first. A serology assay was conducted and fluorescent-antibody-to-membrane-antigen test performed to measure the antibody titers against varicella before and approximately 30 days after the second dose. Of 1,078 participants, most tolerated the second dose well. Age at first dose did not affect the response to vaccination. Geometric mean titers (GMTs) significantly differed between group 1 and all other groups, both before and after the second vaccination. The GMT for group 1 was higher than those for the other 3 groups prior to the second vaccination (GMT = 20.52, 14.68, 12.49, 12.29, respectively, p < 0.001 for all), while the opposite was true after the second vaccination (GMT = 51.14, 83.37, 85.01, 81.83, respectively, p < 0.001 for all). There was no significant difference in seropositive rate among the 4 groups prior to the second vaccination (p = 0.093), and these rates were all 100% after the second vaccination. The vaccine was well tolerated in healthy children, regardless of the timing of the second dose. GMTs showed a particularly high boost after the second dose when the interval between doses was more than 1 year.

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Factors Associated With Receipt of Two Doses of Varicella Vaccine Among Adolescents in the United States

Cited by 9 publications

References 19 publications

Parental Attitudes and Factors Associated With Varicella Vaccination in Preschool and Schoolchildren in Hong Kong

Parental Attitudes and Factors Associated With Varicella Vaccination in Preschool and Schoolchildren in Hong Kong

Trends in varicella and mumps vaccination rates in children under 3 years of age in a tertiary children's hospital in Japan

Immunogenicity and safety of different schedules of 2-dose varicella vaccination in China

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