Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Muruaga, M.M. Contreras; Reig, G; Vivancos, José; Cardona, Pere; Ramírez-Moreno, J.M.; Martí‐Fàbregas, Joan; Fernández, Carmen Suárez; Pose, Antonio; Díaz, José; Rodrı́guez, Manuel; Pena, Marta; Arias, Susana; Larrosa, Davinia; González, Álvaro; Rodriguez, E. Medez; González, M. Domínguez-Gil; Fernàndez, Dolores; Barbagelata, Cristina; Raña, Natividad; Freire, Santiago Jesús Camacho; Cerqueiro, J.M.; Guerrero, H; Ramos, Laura Prósper; Álvarez, Leticia García; Lis, José M. de; Caro, C.M.; Seijo, Manuel; Mederer, S.; Zarraga, Miguel Alberto de; Ferreiro, José Luis; Terrero, José M.; Árias, Mônica Vicky Bahr; Perez, Roberto Salomon; Sánchez, Joaquín; Maciñeiras, José; Fernández, J; Jaén, Fernando; Esteva, David; Zamora, M.; Navarrete, Nuria Navarrete; García, Javier Muñiz; Mérida, Luis; Corrales, Miguel Ángel; Quirós, Raúl Guzmán; Cantero, J Peñas; Barrero, Francisco Javier; Villegas, Inmaculada; Castro, José; Foronda, Jesús; Carrillo, Dionisio; Vega, Jesús; Trujillo, José Antonio Jiménez; Montero, Manuel; Jurado, Ana Rosa; Sánchez, Carlos Jerjes; Agüera-Morales, Eduardo; Sánchez, María Elena Reyes; Durán, Purificación; Puerta, Rafael Fernández de la; Blanca, María Pérez de la; Martínez, María Paz; Fernández, Óscar; Tamayo, José Antonio; Castellanos, Rafael; Serrano, Pedro Jesús; Arjona, Antonio; Fernández, Javier; Payan, Manuel; Gómez, Ricardo; Pena, Daniel Pereira; Cabrerizo, Enrique; Salgado, Fernando; Georgieva, Radka Ivanova; Gil‐Núñez, A.; Bello, Elena; Dı́az, Fernando; Medina, Antonio Rubio; Castellano, Ana; Miranda, Yesica; Fabre, Óscar; Polo, Iluminada García; Ibáñez, Patricia Ibáñez; Sainz, Clara; Sierra, Fernando; Aragón, Esther; Díaz, Jaime; Aguilar, Fernando Salcedo; Ortega, M. A. Herranz; Egido, J.A.; Pontes, José Carlos Dorsa Vieira; García, Miguel Ángel Bonillo; Cabrera, Francisco; Batalla, Blanca; Culla, Alex; Molina, Carlos A.; Flores, Alan; Seró, Laia; Muchada, Marián; Meler, Pilar; Boned-Riera, Sandra; Cánovas, David; Estela, Jordi; Font, Juli; Purroy, Francisco; Benabdelhak, Ikram; Sanahuja, Jordi; Roquer, Jaume; Rodríguez, Ana; Ois, Ángel; Cuadrado, Elisa; Jimenez, J. J.; Nogués, Xavier; Kuprinski, Jerzy; Герман, А. И.; Irigoyen, Daniel; Cara, Juan José; Font, Maria Àngels; Huertas, Sonia; Martínez‐Domeño, Alejandro; Arroyo, Juan Antonio; Delgado-Mederos, Raquel; Gómez-Choco, Manuel; Mengual, Juan José; García, Sonia Margarita Vivas; Castellanos, Maricel; Eedenburg, Cecile van; Cañas, Imma; Espinosa, J.; Montull, Santiago; Quesada, Helena; Ustrell, Xavier; Homedes, Christian; Navalpotro, Irene; Casanova, Jordi; Lago, Aída; Morata, Carmen; Górriz, David; Moreno, I Goni; Tembl, José Ignacio; Ponz, Alejandro; Fonseca, Mih; Chamarro, Raquel; Gil, Rosario; Oliver, V.; Pampliega, A.; Artero, Arturo; Puchades, Francesc; Landete, L; Vilar, Carlos; Jiménez, Carmen Rodríguez; Vives, Bárbara; Moragues, María Dolores; Díaz, Rosa; Tur, Sílvia; Escribano, José Bernardo; Lucas, César; Martínez, Francisco; Pons, José Miguel; Romero, Amparo; García, David; Pérez, José Ignacio de Ulíbarri; Villaverde, Ramón; Martínez, Salvadora; Rodríguez, Aida; Tejero, Carlos; Pérez, Cristina Fernández; Mostacero, E; Fernández, C. Suárez; Luna, Alain; Pérez, Tomás; González, Félix; Arce, Ana de; Martínez, M A; Díez, Noemí; Gállego, J.; Zandio, Beatriz; Herrera, María; Aymerich, N.; Castro-Muñoz, Roberto; Marta, J.; Artal, Jorge; Errea, José M.; Timiraos, Juan José; Moreno, Mauricio; Freijo, Mar; García, Juan Manuel Martínez; Gil, M. Carmen; Revilla, Marián; Palacio, Enrique; Vázquez, José Luís; Bestué, M; Latorre, Ana; Calvo, Eva; Ballester, Laura; Serrano, Marta; Juega, Jesús; Lopez, Michael A.; Irimia, P.; Imaz, Laura; Fuentes, Blanca; Sanz, Borja Enrique; Beltrán, Luis M.; Ruiz, Gerardo; Martínez, P.; Sánchez, Demetrio López; Barroso, Emilio; Molina, Igor; Budiño, Marco Antonio; Masjuán, Jaime; Felipe, Alicia de; Matute, Consuelo; Tejada, J.; Morán, Alberto; Fernández, E Luengo; Riveira, M. del Carmen; Carnedo, Joaquín; Manquillo, A; González, Raquel; Fernández, José Carlos; Guillán, M.; Yebra, M; Trejo, José María; Saiz, Jesús Minaya; Martínez-Acitores, Juan Carlos; Bravo, Yolanda; Arenillas, Juan F.; Calleja, Ana; Cortijo, Elisa; Reyes, Javier; López, L. Usieto; Muñoz, Pedro Luis; Fidalgo, M.A.; Hernandez, Jacinto A.; Gomez, Jose Carlos; Moran, Jose C; Gonzalo, Sonia; Marrero, Jorge A.; Satué, J.A.; Belinchón, Juan Carlos; Moniche, Francisco; Calderón, E.; Escudero, Irene; Torre, Javier de la; Casado, I.; Antón, Joaquín; Portilla, Juan Carlos; Luengo, Juan; Rosal, Joan; Calzado, Elena; Anglada, J.; Girón, J.; Ramı́rez, José M.; Pijierro, Agustín; Roa, A.M. Acosta; Romero, Jorge del; Aguayo, Mariano; Borrachero, Cristina; Sanz, Gema; Gómez, María José; Rico, Miguel Ángel; Cayon, Antonio; Carmona, Eduardo Agüera; Cerro, Román; Lopez, R. Botero; Aguirre, Alfonso; Lozano, F.; Rivera, J.Miguel

doi:10.1016/j.rceng.2018.04.018

Cited by 2 publications

(1 citation statement)

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“…In the Asian population, 18.8 and 13.1% of patients are either undertreated or overtreated, respectively, with a significant increase in adverse effects (43). Regarding the type of anticoagulant used, almost 50% of the patients treated with VKA are not well-anticoagulated, have diabetes, have labile INR, and have a high HAS-BLED score being associated with poor coagulation control (44). Although compliance is better with DOACs than with VKA, it has been reported that 13% of the AF patients receive DOAC doses that are inconsistent with labeling (9.4% underdosed and 3.4% overdosed) (45).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Anticoagulation in Secondary Ischemic Stroke Prevention: The Prospective Multicenter RESTAIC Registry

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Long-Term Anticoagulation in Secondary Ischemic Stroke Prevention: The Prospective Multicenter RESTAIC Registry

et al. 2020

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Clinical profile and management of rivaroxaban in patients with atrial fibrillation in routine practice in Spain: data from six nationwide studies

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et al. 2019

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AimsTo analyze the clinical profile and management of patients with nonvalvular atrial fibrillation taking rivaroxaban in routine practice in Spain.MethodsClinical data from the observational studies HEROIC (cardiology and hematology; n=1,727), EMIR (cardiology; n=1,493), BRONCE-AP (primary care; n=133), SILVER-AP (primary care; n=457), ALADIN (internal medicine and neurology; n=249), and ESPARTA (internal medicine; n=110) of patients taking rivaroxaban were analyzed. The clinical profile was compared with those of the XANTUS and ROCKET-AF studies.ResultsOverall, mean age was 74.9±9.4 years, CHA2DS2-VASc score was 3.7±1.5, and 43.2% had a HAS-BLED score ≥3. Patients included in the HEROIC and EMIR studies were older and more frequently had a creatinine clearance <50 mL/min and a higher thromboembolic risk than those in the XANTUS study, and patients included in the ALADIN study were older and had more prior cerebrovascular disease, but a lower thromboembolic risk than those in the ROCKET-AF trial. In those studies with available data, medication adherence and satisfaction with rivaroxaban were high.ConclusionBearing in mind differences according to the clinical setting of each study, atrial fibrillation patients taking rivaroxaban in Spain were elderly and had a high thromboembolic risk. Medication adherence and satisfaction with rivaroxaban were high.

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Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Cited by 2 publications

References 28 publications

Long-Term Anticoagulation in Secondary Ischemic Stroke Prevention: The Prospective Multicenter RESTAIC Registry

Long-Term Anticoagulation in Secondary Ischemic Stroke Prevention: The Prospective Multicenter RESTAIC Registry

Clinical profile and management of rivaroxaban in patients with atrial fibrillation in routine practice in Spain: data from six nationwide studies

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