Factors Associated with Peripheral Blood Stem Cell Yield in Volunteer Donors Mobilized with Granulocyte Colony-Stimulating Factors: The Impact of Donor Characteristics and Procedural Settings

Wang, Tso Fu; Wen, Shu‐Hui; Chen, Rong-Long; Lu, Chi Jui; Zheng, Yu; Yang, Sung-Byung; Chu, Sung Chao; Kao, Ruey Ho; Chen, Shu Huey

doi:10.1016/j.bbmt.2008.09.002

Cited by 69 publications

(79 citation statements)

References 21 publications

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“…Similar to reports by other authors [6,13,[23][24][25] our data show strong association between donor age of 55 years or more and reduced PBSC mobilization.…”

Section: Discussionsupporting

confidence: 82%

Outcomes of 167 healthy sibling donors after peripheral blood stem cell mobilization with G-CSF 16μg/kg/day: efficacy and safety

Krejčí¹,

Janíková²,

Folber³

et al. 2015

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Mobilization of peripheral blood stem cells (PBSC) using the granulocyte colony-stimulating factor (G-CSF) has enabled the collection even from older donors and those with comorbidities. Several clinical parameters have been reported to predict the success of PBSC mobilization.The aim of our study was to evaluate the safety of PBSC donation in a cohort of 167 sibling donors after mobilization with G-CSF 16 μg/kg/day for 5 days during short-and long term follow-up and to analyse the efficacy, toxicity and factors influencing CD34+ mobilization capacity.All 167 sibling donors completed the established mobilization protocol. The median yield was 7.9x10 6 CD34 cells/kg per recipient weight. The optimal target dose of CD34 cells ≥ 4.0x10 6 /kg was achieved in 140 donors (84%). Only in 4 donors (2%) was the CD34+ yield < 2x10 6 /kg. No major toxicities occured. Factors associated with higher PBSC yields included age < 55 years (p= 0.001), male gender (p= 0.004), preapheresis CD34 cell counts > 51/μL (p < 0.001) and preapheresis leukocyte counts > 45.5 x 10 9 /L (p = 0.003). Comorbidity score, performance status and donor weight did not significantly influence PBSC yields. Long-term follow-up was possible in 60% (101/167) of the donors. The median length of follow-up from PBSC donation was 11.9 years. Most of these donors reported good or very good general health (91%), and no hematological malignancies were observed.The mobilization of PBSC in sibling donors with G-CSF 16 μg/kg/day is an effective and safe procedure with no significant short-and long-term toxicities.

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“…Similar to reports by other authors [6,13,[23][24][25] our data show strong association between donor age of 55 years or more and reduced PBSC mobilization.…”

Section: Discussionsupporting

confidence: 82%

Outcomes of 167 healthy sibling donors after peripheral blood stem cell mobilization with G-CSF 16μg/kg/day: efficacy and safety

Krejčí¹,

Janíková²,

Folber³

et al. 2015

neo

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“…A different interaction to G-CSF between genders had been suggested. We had recently demonstrated that female gender had a higher risk (odds ratio = 3.01) for having a poor stem cell yields than other donor characteristics [12]. However, the marrow cell densities were not different between two genders in present study.…”

Section: Discussionmentioning

confidence: 44%

Correlation between characteristics of unrelated bone marrow donor and cell density of total nucleated cell in bone marrow harvest

Kao

Shaw

et al. 2009

Int J Hematol

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The relationship between the features of bone marrow donor and the quality of marrow harvest has been unclear because most of bone marrow registries have multiple collection centers with somewhat different harvest procedures. We are able to address this issue for Tzu Chi General Hospital is the only collection center affiliated with Tzu Chi Taiwan Bone Marrow Registry. Between November 1997 and March 2002, data of 286 healthy unrelated donors was analyzed to correlate with the cell density of total nucleated cell in bone marrow harvests. The harvest procedure was standardized by single-hole harvest needle under general anesthesia. The operation staffs were restricted within the members of Oncology-Hematology division. The results showed that the cell density of bone marrow harvest was positively correlated with donor body weight and peripheral white blood cell count P = 0.0475, P < 0.0001, but negatively correlated with the total volume of bone marrow harvest P < 0.0001. We recommend that if multiple human leukocyte antigen-matched donors are available, donor with higher body weight and/or higher white blood cell count be selected for allogeneic bone marrow transplantation.

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“…G-CSF (Filgrastim, Kirin Brewery Co., Tokyo, Japan) was given subcutaneously at dosage of 10 μg/kg per day for 5-6 consecutive days. The actual G-CSF dose was adjusted to fit the combination of available dosage forms in our institute [7]. The first 4-5 doses of G-CSF were administrated at local clinics near donor's residence.…”

Section: Donors and Stem Cell Mobilizationmentioning

confidence: 99%

The role of donor characteristics and post-granulocyte colony-stimulating factor white blood cell counts in predicting the adverse events and yields of stem cell mobilization

et al. 2011

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Granulocyte colony-stimulating factor (G-CSF) is now widely used for stem cell mobilization. We evaluated the role of post-G-CSF white blood cell (WBC) counts and donor factors in predicting adverse events and yields associated with mobilization. WBC counts were determined at baseline, after the third and the fifth dose of G-CSF in 476 healthy donors. Donors with WBC ≥ 50 × 10(3)/μL post the third dose of G-CSF experienced more fatigue, myalgia/arthralgia, and chills, but final post-G-CSF CD34(+) cell counts were similar. Although the final CD34(+) cell count was higher in donors with WBC ≥ 50 × 10(3)/μL post the fifth G-CSF, the incidence of side effects was similar. Females more frequently experienced headache, nausea/anorexia, vomiting, fever, and lower final CD34(+) cell count than did males. Donors with body mass index (BMI) ≥ 25 showed higher incidences of sweat and insomnia as well as higher final CD34(+) cell counts. Donor receiving G-CSF ≥ 10 μg/kg tended to experience bone pain, headache and chills more frequently. Multivariate analysis indicated that female gender is an independent factor predictive of the occurrence of most side effects, except for ECOG > 1 and chills. Higher BMI was also an independent predictor for fatigue, myalgia/arthralgia, and sweat. Higher G-CSF dose was associated with bone pain, while the WBC count post the third G-CSF was associated with fatigue only. In addition, one donor in the study period did not complete the mobilization due to suspected anaphylactoid reaction. Observation for 1 h after the first injection of G-CSF is required to prevent complications from unpredictable side effects.

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Factors Associated with Peripheral Blood Stem Cell Yield in Volunteer Donors Mobilized with Granulocyte Colony-Stimulating Factors: The Impact of Donor Characteristics and Procedural Settings

Cited by 69 publications

References 21 publications

Outcomes of 167 healthy sibling donors after peripheral blood stem cell mobilization with G-CSF 16μg/kg/day: efficacy and safety

Outcomes of 167 healthy sibling donors after peripheral blood stem cell mobilization with G-CSF 16μg/kg/day: efficacy and safety

Correlation between characteristics of unrelated bone marrow donor and cell density of total nucleated cell in bone marrow harvest

The role of donor characteristics and post-granulocyte colony-stimulating factor white blood cell counts in predicting the adverse events and yields of stem cell mobilization

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