Factors Associated With Isolated Right Heart Failure in Women: A Pilot
                        Study From Western Kenya

Lagat, David; DeLong, Allison; Wellenius, Gregory A.; Carter, E. Jane; Bloomfield, Gerald S.; Velázquez, Eric J.; Hogan, Joseph W.; Kimaiyo, Sylvester; Sherman, Charles B.

doi:10.1016/j.gheart.2014.04.003

Cited by 17 publications

(11 citation statements)

References 40 publications

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“…Laabes et al 25 identified alcohol consumption, obesity and metabolic dysfunction as additional risk factors. Environmental factors, including poor kitchen ventilation and exposure to occupational dust, have been linked to cases of right-sided heart failure in Kenya 26. Enteroviruses and HIV have been identified as risk factors for cardiomyopathy and right-sided heart failure, respectively 26 27…”

Section: Resultsmentioning

confidence: 99%

What is known about heart failure in sub-Saharan Africa: a scoping review of the English literature

Kimani

Namukwaya

Grant

et al. 2016

BMJ Support Palliat Care

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We systematically reviewed and summarised existing knowledge on heart failure in sub-Saharan Africa (SSA). We searched the following databases Web of Science, EMBASE, Ovid MEDLINE, PsychINFO, Global Health, CINAHL and African Journals Online using a combination of key words: heart failure or congestive heart failure or cardiac failure. We limited our search to studies conducted in SSA and articles published 2000-2014. Twenty-seven articles met our inclusion criteria and all were quantitative studies. Existing knowledge is focused on 3 key areas: (1) epidemiology of heart failure, (2) psychological burden of heart failure, and (3) patient knowledge and compliance to treatment. SSA would benefit from longitudinal qualitative research on the experience of living with heart failure.

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Section: Resultsmentioning

confidence: 99%

What is known about heart failure in sub-Saharan Africa: a scoping review of the English literature

Kimani

Namukwaya

Grant

et al. 2016

BMJ Support Palliat Care

View full text Add to dashboard Cite

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“…Another study from Malawi among 222 adults with acute stroke and 504 non-stroke controls identified HIV as the predominant risk factor for stroke among participants ≤ 45 years [91]. A small pilot study comparing ≥ 35-year-old women with isolated right heart failure to similarly aged controls reported an adjusted odds ratio for HIV status of 40 [95% CI 3.7–441], i.e., women with heart failure had a 40-fold greater odds of having HIV compared to women without heart failure—note: wide confidence intervals reflect small sample size of 31 cases and 65 controls [92•]. A cross-sectional echocardiographic study of cardiac structure and function among children (mean 8 years) reported increased prevalence of left ventricular systolic dysfunction among those with HIV compared to those without HIV [93].…”

Section: Cvd and Hiv In Special Populationsmentioning

confidence: 99%

“…Of equal relevance as these biologically focused mechanisms are societal and environmental factors that often do not make it into cardiovascular disease prediction models. These include issues ranging from polypharmacy associated with managing multiple chronic diseases (e.g., HIV and heart failure) [131], healthcare disparities associated with HIV status that impact cardiovascular disease prevention and care [21–23], economic disparities that impact exposure to environmental pollution [92•], and clinical cardiovascular guidelines that may not account for HIV status when designating high-risk populations that could benefit from strategies beyond usual care.…”

Section: Cvd Risk Assessment and Novel Cvd Risk Factors In Hivmentioning

confidence: 99%

HIV and Cardiovascular Disease: Update on Clinical Events, Special Populations, and Novel Biomarkers

So‐Armah

Freiberg

2018

Curr HIV/AIDS Rep

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Heart failure, peripheral artery disease, and stroke are CVD modalities deserving more attention in the context of HIV infection in the highly active antiretroviral therapy era. Incidence data on clinical CVD from HIV populations in low- and middle-income countries are limited. Multisubstance use is common in HIV, but understudied as a moderator or mediator of the association between HIV and CVD. CVD risk assessment in HIV remains challenging, but new research into novel biomarkers may provide further insights. There is also a need for inclusion of non-biologic factors in our attempts to understand, quantify, and predict CVD risk among PLWHA. Significant attention has been paid to generating and testing hypotheses to understand the mechanisms of myocardial infarction in HIV. Similar attention is deserving for heart failure, PAD, stroke, and cardiovascular disease risk in resource-limited settings and among substance users with HIV.

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“…58 Women, who perform a majority of the cooking, often in poorly ventilated kitchens, endure the greatest exposure. 59 However, a direct link between household air pollution and CVDs has not yet been demonstrated. The associations between higher ambient fineparticle concentration and increased risk of IHD, stroke, and heart failure are more clear.…”

Section: Environmental Infectious and Early Life Nutritional Risk Fmentioning

confidence: 99%

Endemic Cardiovascular Diseases of the Poorest Billion

et al. 2016

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The 2 most commonly used approaches for measuring poverty are (1) 1-dimensional approaches focused on income or Abstract-The poorest billion people are distributed throughout the world, though most are concentrated in rural sub-Saharan Africa and South Asia. Cardiovascular disease (CVD) data can be sparse in low-and middle-income countries beyond urban centers. Despite this urban bias, CVD registries from the poorest countries have long revealed a predominance of nonatherosclerotic stroke, hypertensive heart disease, nonischemic and Chagas cardiomyopathies, rheumatic heart disease, and congenital heart anomalies, among others. Ischemic heart disease has been relatively uncommon. Here, we summarize what is known about the epidemiology of CVDs among the world's poorest people and evaluate the relevance of global targets for CVD control in this population. We assessed both primary data sources, and the 2013 Global Burden of Disease Study modeled estimates in the world's 16 poorest countries where 62% of the population are among the poorest billion. We found that ischemic heart disease accounted for only 12% of the combined CVD and congenital heart anomaly disabilityadjusted life years (DALYs) in the poorest countries, compared with 51% of DALYs in high-income countries. We found that as little as 53% of the combined CVD and congenital heart anomaly burden (1629/3049 DALYs per 100 000) was attributed to behavioral or metabolic risk factors in the poorest countries (eg, in Niger, 82% of the population among the poorest billion) compared with 85% of the combined CVD and congenital heart anomaly burden (4439/5199 DALYs) in high-income countries. Further, of the combined CVD and congenital heart anomaly burden, 34% was accrued in people under age 30 years in the poorest countries, while only 3% is accrued under age 30 years in high-income countries. We conclude although the current global targets for noncommunicable disease and CVD control will help diminish premature CVD death in the poorest populations, they are not sufficient. Specifically, the current framework (1) excludes deaths of people <30 years of age and deaths attributable to congenital heart anomalies, and (2) emphasizes interventions to prevent and treat conditions attributed to behavioral and metabolic risks factors. We recommend a complementary strategy for the poorest populations that targets premature death at younger ages, addresses environmental and infectious risks, and introduces broader integrated health system interventions, including cardiac surgery for congenital and rheumatic heart disease.

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Factors Associated With Isolated Right Heart Failure in Women: A Pilot Study From Western Kenya

Cited by 17 publications

References 40 publications

What is known about heart failure in sub-Saharan Africa: a scoping review of the English literature

What is known about heart failure in sub-Saharan Africa: a scoping review of the English literature

HIV and Cardiovascular Disease: Update on Clinical Events, Special Populations, and Novel Biomarkers

Endemic Cardiovascular Diseases of the Poorest Billion

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