Factors Associated with Health-Related Quality of Life in Mexican Lupus Patients Using the LupusQol

Abstract

IntroductionHealth-related quality of life (HRQOL) is affected by numerous clinical variables, including disease activity, damage, fibromyalgia, depression and anxiety. However, these associations have not yet been described in Mexican patients with systemic lupus erythematosus (SLE).ObjectiveTo evaluate the relationship between disease activity, damage, depression and fibromyalgia and HRQOL measured by the LupusQoL-instrument in Mexican patients with SLE.MethodsA cross-sectional study was conducted in women fulfilling the 1997 ACR classification criteria for SLE. HRQOL was evaluated using a disease-specific instrument for SLE, the LupusQoL (validated for the Spanish-speaking population). Patients were evaluated clinically to determine the degree of disease activity and damage using the Mexican Systemic Lupus Erythematosus Disease Activity Index (Mex-SLEDAI) and Systemic Lupus International Collaborating Clinics-Damage Index (SLICC), respectively. Fibromyalgia and depression were assessed using the ACR criteria and the CES-D scale, respectively. The relationship between HRQOL and these variables was measured using Spearman’s rank correlation coefficient and linear regression analysis.ResultsA total of 138 women with SLE, age 40.3±11 years, disease duration 8.8±6.4 years, with disease activity in 51.4%, depression in 50%, damage in 43% and fibromyalgia in 19.6% were included. Poorer HRQOL correlated with depression (r = -0.61; p< 0.005), fibromyalgia (r = -0.42; p< 0.005), disease activity (r = -0.37; p < 0.005) and damage (r = -0.31; p < 0.005). In the multivariate linear regression analysis, damage (β = -3.756, p<0.005), fibromyalgia (β = -0.920, p<0.005), depression (β = -0.911, p<0.005) and disease activity (β = -0.911, p<0.005) were associated with poor HRQOL.ConclusionSLE disease activity, damage, fibromyalgia and depression were associated with poor HRQOL in our sample of Mexican SLE patients.

Differences in quality of life determinants according to the presence of fibromyalgia in middle‐aged female patients with systemic lupus erythematosus: a multicenter, cross‐sectional, single‐ethnicity cohort

“…Here, we attempted to identify differences in the determinants of HRQoL between SLE patients with fibromyalgia and those without fibromyalgia. Previous studies have identified the presence of fibromyalgia as a negative influencing factor on HRQoL in SLE patients . However, none of the reports have examined the factors contributing to HRQoL in SLE patients classified according to the presence and absence of fibromyalgia.…”

Dermoscopic patterns of filiform papillae of the tongue in patients with and without connective tissue autoimmune diseases

“…Like other conditions, SLE is more common in females (90%), and although young women (of reproductive age) are primarily affected, this disease can occur at any age. 18,19 In our study, after RA, LES and mixed connective tissue disease were the most frequent conditions, specifically MCTD does not meet the diagnostic criteria for any of the other CTADs or have clinical and immunological features that suggest them. Nevertheless, the time of evolution and follow-up of these patients allow the correct diagnosis to be made.…”

Depression and Quality of Life in People with Systemic Lupus Erythematosus

“…Studies have shown that depression has a correlation to feeling one is a burden to others, fatigue (O'Riordan, Doran, & Connolly, 2017) and body image (O'Riordan et al, 2014). Results show-ing a feeling of being a burden to others, fatigue, and poor emotional health was revealed in research by Etchegaray-Morales et al, 2017. This indicates that depression is correlated to feeling of tiredness, negatives emotions, negative appraisal regarding appearance, and a feeling of becoming a burden for those around one. The differences in the results from studies in various countries become an important focus for study, to determine the correlation between depression and aspects of quality of life for people with SLE, in Indonesia.…”