Factors associated with creatinine increase in older adults with hip fracture

Abstract

Background: Acute kidney injury (AKI) is a common complication among older adults with hip fracture. Factors such as baseline renal function, comorbidities, the use of nephrotoxic drugs, and age increase the incidence of this complication. Objectives: To find factors related to higher creatinine levels among older adults with hip fracture upon admission, discharge, and during hospitalization in a hospital setting in Mexico. Methods: This was an observational, comparative, longitudinal, and retrospective study. Setting and participants: Data from patients aged 60 and over with hip fracture presenting to the ER from January 2020 to August 2021 with at least one creatinine determination on admission and one at discharge were analyzed (n = 99). Using longitudinal linear regressions, factors associated to higher creatinine levels on admission and at discharge, AKI, and higher increase in creatinine levels during hospitalization were analyzed. Results: Higher creatinine levels on discharge were seen in older patients (p < 0.003), among those with higher creatinine levels on admission (p < 0.000) and those with higher body mass index (BMI) (p < 0.014). Individuals with higher BMI showed significantly higher increase in creatinine levels (p < 0.05). Conclusions: Our study found that individuals with previous risk factors for AKI showed higher creatinine levels on discharge, but none of these factors predicted AKI significantly.