Factors affecting spine–femur discordance in the percentage of young adult mean on dual-energy X-ray absorptiometry in the elderly population: a retrospective study

Akiyama, Shoshi; Tanaka, Takaaki; Udaka, Jun; Inagaki, Naoya; Kumagae, Yoshio; Chazono, Masaaki; Matsuoka, Tatsuki; Saito, Mitsuru

doi:10.1186/s12891-022-05015-3

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Today, POP is the most common form of osteoporosis due to natural aging [ 3 , 4 ]. The latest seventh national population census of China [ 5 ] showed that the country has the largest absolute number of older person in the world, at 260 million and 190 million aged above 60 and 65, respectively.…”

Section: Introductionmentioning

confidence: 99%

Prevalence rate of primary osteoporosis in China: a meta-analysis

Lyu,

Ramoo,

Chui

et al. 2024

BMC Public Health

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Background Primary osteoporosis (POP) is recognized as a “silent disease” and often ignored. This meta-analysis aimed to determine the prevalence of POP in the Chinese population over the past 20 years to raise awareness of the disease’s epidemiology, which is hoped to help prevent and treat the condition better. Methods Eight English and three Chinese language databases were searched systematically from January 2002 to December 2023. Relevant data were analysed using Stata 16.0. Meta-regression and subgroup analyses were performed to explore causes of heterogeneity. A funnel plot was further drawn in combination with Egger and Begg tests to determine publication bias. Results A total of 45 studies (241,813 participants) were included. The meta-analysis revealed that the overall prevalence of POP in the Chinese population was 18.2% (95% CI: 14.7–21.7%), showing a positive correlation with age. Specifically, prevalence rates were 23.4% (18.3–28.5%) in women and 11.5% (9.1–13.9%) in men. A notable increase was observed within the span of 20 years (16.9% before 2010 and 20.3% in 2011–2020). Notably, regional variations were observed, with southern China reporting a lower prevalence of 16.4% compared to 20.2% in northern China. Meta-regression suggested that sample size significantly influenced the estimation of point prevalence (P = 0.037). Conclusions Over the past two decades, there has been an increase in the prevalence of POP within the Chinese population. The growing prevalence of older individuals and women further highlights the urgency for tailored disease prevention and control measures.

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Section: Introductionmentioning

confidence: 99%

Prevalence rate of primary osteoporosis in China: a meta-analysis

Lyu,

Ramoo,

Chui

et al. 2024

BMC Public Health

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“…Extensive evidence links exposure to such chemicals with heightened susceptibility to endocrine disorders and chronic ailments [10], as well as discernible impacts on bone health [11,12]. Furthermore, it is worth noting that while a correlation exists between BMD across various skeletal regions, discrepancies can arise between BMD measurements in the lumbar spine and the hip, giving rise to divergent classi cations of bone loss, commonly referred to as spine-femur BMD discordances [13]. These discordances can result in certain individuals with osteoporosis not receiving appropriate treatment.…”

Section: Introductionmentioning

confidence: 99%

Contrasting Negative Effects of Multipollutant Exposure on Femoral and Spinal Bone Mineral Density: Findings from a Population-based Study in US Adults

Zheng

Luo

et al. 2023

Preprint

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Summary Multipollutant exposures negatively impact femoral and spinal bone mineral density (BMD) in US adults. polycyclic aromatic hydrocarbons (PAHs) are detrimental to femoral BMD, while phthalates are associated with decreased spinal BMD. Urgent actions are required to mitigate these environmental exposures and preserve bone health. Purpose: The objective of this study was to examine the relationship between environmental exposures and osteoporosis. The study aimed to assess the impact of four categories of environmental chemicals, namely heavy metals, phthalates, PAHs, and phenols, on BMD. Methods: A population-based sample of 3029 participants from the United States was utilized for this investigation. Various statistical methods including generalized linear regression, generalized additive models (GAMs), quantile g-computation (Qgcomp) approach, and Bayesian kernel machine regression (BKMR) were employed to analyze the relationship between environmental chemicals and BMD. Results: The study findings demonstrate a negative association between blood and urine levels of environmental chemicals and BMD in the US adult population. Notably, the association between chemical exposure and BMD varied significantly between the spine and femur regions. The analysis further revealed distinct negative correlations between chemical mixtures and BMD in these two regions. Conclusion: This study provides compelling evidence of the detrimental effects of multipollutant exposures to heavy metals, phthalates, PAHs, and phenols on BMD in the US population. Moreover, the study highlights the divergent negative associations observed between the spine and femur regions, with PAHs exerting a more pronounced adverse effect on BMD in the femoral region and phthalates exhibiting a stronger negative association with BMD in the total spine. These findings underscore the importance of minimizing exposure to these specific pollutants, particularly in individuals experiencing disparities in BMD between the spine and femur.

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