Factors affecting mortality and treatment completion of tuberculosis patients in Isfahan Province from 2006 to 2011

Abstract

Background:Regarding cases of infectious diseases tuberculosis (TB) is the most important cause of death and according to the DALY criteria, this disease has the seventh position in global disease ranking. In this study, we aim to determine the risk factors, which have a significant effect on the treatment completion and mortality of TB patients.Methods:This study is a retrospective cohort study. The sample is made up of registered TB patients in the Isfahan Province from 2006 to 2011. Information of the patients was collected from their files in health centers in the Isfahan Province. Variables such as age, sex, weight, nationality, residence, type of TB, imprisonment, human immunodeficiency virus, TB case were measured. Descriptive statistics (including frequency, percentage, mean and standard deviation) and statistical analysis (including Cox proportional hazard model) were used.Results:The result showed that imprisonment (hazard ratio [HR] = 4.76, P = 0.019), age (HR = 4.44, P = 0.001) and the TB case (HR = 2.73, P = 0.037) of pulmonary TB had significant impacts on mortality of the patients, also in the case of treatment completion, the TB case (HR = 0.34, P < 0.001) proved to have a significant impact on completion of the treatment. Type of extra-pulmonary TB in extra-pulmonary TB patients also had an effect on treatment completion.Conclusions:We can conclude that factors such as age, imprisonment, TB case and type of extra-pulmonary TB are effective on the treatment completion and mortality of the patients. It may be useful for policy makers to make more control of high-risk patients.

Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

“…Mortality shows significant relation with increasing age, poverty, anemia, CLD, DM, HIV, HTN, recurrent TB, and smoking. Similar to our result different studies show the significance of various risk factors and mortality 18,21,22. A Pakistani study by Khaliq A et al on different social and environmental risk factors in PTB patients reported the significant relation of PTB mortality with male gender, poverty, smoking, DM, asthma, HIV, and reoccurrence of TB 21.…”

“…First important finding of current study was the higher rate of mortality in PTB patients i.e., 13.5%, whereas most of the other studies reported the lower mortality prevalence than current study such as Asgedom SW et al, 11.3%,17 Shahrezaei M et al, 1.6%,18 and Rodrigo T et al, 3.5% 19. Another study by Takarinda KC et al reported the higher prevalence of mortality 22.0% in TB patients 20.…”

“…Study by Shahrezaei M et al reported the significant relation of mortality with increasing age, weight, and TB case. Other important reported factors were DM, and HIV 18. Another study by Alavi-Naini R et al reports the anemia, smoking, DM, HIV, drug abuse, hepatitis, and recurrent TB as a predictor for PTB mortality 22…”

“…Direct involvement of different risk factors for this dilemma are the distinct reason of increasing infection susceptibility, and PTB progression 15,16. These factors also play vital role in prediction of mortality in PTB patients, such as increasing age, poor health care facilities due to poverty, low income, anemia, CLD, DM, HIV, HTN, recurrent TB, and smoking 17,18…”

Serum enolase-2, high-sensitivity C-reactive protein, and serum cholesterol in smear-positive drug-naïve pulmonary tuberculosis

“…[ 7 ] Enolase-2 (ENO-2) is the phosphopyruvate hydratase enzyme of glycolysis of neuron origin; hence, it is also known as ENO-γ or the neuron-specific enolase (NSE). [ 8 9 ] ENO-2 is found in various tissues including the brain, macrophages, neuroendocrine cells, neuroendocrine cells tumors, such as the small cell lung cancer,[ 10 11 ] active PTB,[ 12 ] and poor neurological outcome in cardiac arrest patients. [ 13 ] The high-sensitivity C-reactive protein (hs-CRP) is an acute phase protein biomarker for inflammatory disease.…”