Factors Affecting Long-Term Survival in Locally Advanced NSCLC Patients With Pathologic Complete Response After Induction Therapy Followed by Surgical Resection

The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives—State of the Art

“…For T1, T2a and T2b, N1 or with single-site N2 involvement, MMT combining chemotherapy and/or radiotherapy followed by lung tumor resection improves survival, with good short-and long-term outcomes [129][130][131][132][133][134]. Prognosis factors associated with improved OS are T and N downstaging, pathological complete response (pCR) [129][130][131]134], and non-pneumonectomy resection. Nevertheless, few patients achieved pCR after a regimen of neo-adjuvant chemotherapy [135,136].…”

“…Most lung cancers, approximately 70%, are diagnosed at an advanced stage [3], and could require a multimodality treatment. After a regimen of neo-adjuvant treatment, the main prognosis factors associated with improved OS are T and N downstaging, and pathological complete response (pCR) [129][130][131]134]. The pCR is strongly correlated with improved survivals, and reflects the neo-adjuvant therapy effect [129][130][131]134].…”

“…After a regimen of neo-adjuvant treatment, the main prognosis factors associated with improved OS are T and N downstaging, and pathological complete response (pCR) [129][130][131]134]. The pCR is strongly correlated with improved survivals, and reflects the neo-adjuvant therapy effect [129][130][131]134]. Recently, innovative systemic therapies were used in neo-adjuvant protocol in order to increase survivals, based on the hypothesis that these treatments would improve the pathological response.…”