Factorial Invariance of Symptom Dimensions in Anxious and Depressive Neuroses

Factor structure of the SCL-90 in a psychiatric population.

“…A major concern that motivated the present investigation arises from the fact that the bulk of all previous factor analyses of the HSCL as well as the SCL-90 have focused on patients selected for symptoms of anxiety and/or depression. Diagnostic differences have been shown to affect the interpretation of factors on the HSCL (Derogatis et al, 1972), and similar results could be expected with the SCL-90.…”

The conundrum of depression clinical trials

“…For example, even though a patient with insomnia may be getting better sleep, his mood may still be low and his psychomotor activity not affected at all. Such pattern of response has been well documented by early clinical investigators ( Derogatis et al , 1972 ). The way that these symptoms can interact with one another in a system ( Fried, 2015 ; Ballard et al , 2018 ) has not been duly considered.…”

Confirmation of the dimensional structure of the scl-90: A study in construct validation

“…I n the case of the SCL-90, there was excellent agreement between the hypothetical and empirical definitions of Depression, and agreement on the Anxiety dimension was very good as well. This was a most welcome finding because previous research on the invariance of these measures suggested that the negative affect dimensions, particularly Anxiety, might not be as stable as some of the others (Derogatis et al, 1972).…”