Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey

Abstract

Factor V Leiden (FV-Leiden) and prothrombin gene mutations (FII G20210A) are well-established independent risk factors for thrombosis. In the recent years, many studies have suggested that these mutations are associated with an increased risk of recurrent pregnancy loss (RPL). We aimed to investigate the prevalence of these molecular defects in subjects with a history of early RPL. One hundred and fourteen women with three or more consecutive unexplained first-trimester miscarriages were compared to 185 parous women with uncomplicated pregnancies from the same ethnic origin. The presence of FV-Leiden and FII G20210A mutations was assessed by polymerase chain reaction analysis. Overall, 11 out of the 114 women with early RPL (9.6%) had either FV-Leiden or FII G20210A mutation, as compared with 16 out of the 185 women with normal pregnancies (8.6%; p = 0.756). The prevalence of FV-Leiden mutation was 7.9% (9/114) in patient group, compared with 7% (13/185) in control group (p = 0.780). One hundred and two patients were primary and 12 were secondary aborters. All FV-Leiden positive cases were primary aborters (8.8%; 9/102, p = 0.584). Concerning the FII G20210A, two out of 114 (1.7%) were first-trimester RPL (primary aborters) and three out of 185 (1.6%) controls were carriers of the FII G20210A mutation (1.7 vs 1.6%, p = 0.931). The results obtained from patients with first-trimester RPL and the control group have no statistical significant differences in the prevalence of FV-Leiden and FII G20210A mutations. These results suggest that mutations have no role in etiology of first-trimester recurrent abortions.

Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

“…The pathophysiology of RPL is complex and poorly understood. Genetic, infective, anatomical, endocrine, and immune defects have been postulated as the causes of RPL [2]. Genetic theory for susceptibility to RPL has been supported by genome-wide association studies [3,4].…”

Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate?

“…For this reason, many authors have chosen to examine separately the impact of hereditary thrombophilia on each trimester of pregnancy. Controlled studies conducted in the European Caucasian women with a history of unexplained RM failed to demonstrate an association between these two polymorphisms and 1st trimester RM [19,39]. The meta-analyses that have adopted this methodology has also revealed a higher ratio of FLV related losses after the 14th week (OR 2.28) compared with 1st trimester RM (OR 1.6-1.91) [20,26,27,40].…”

Study the Correlation Between Polymorphism of MTHFR Thrombophilic Genes and Pregnancy Loss in Ahvaz City

“…Recurrent pregnancy loss is one of the most common problems associated with pregnancy and roughly 2% of women suffer from it 3 . It is usually known as a multi-factoral and complicated disease and various danger factors such as genetics, infections, anatomical, hormonal and immune problems are involved in it 4 . Although the cause of this disease may remain unknown in some cases, about 55% of the patients are report to be afflicted with thrombophilic disorders 5 .…”