Factitious disorder mimicking addiction to levodopa in a patient with advanced Parkinson's disease

Teixeira-Jr, Antônio Lúcio; Cardoso, Francisco

doi:10.1590/s0004-282x2005000200023

Cited by 3 publications

(1 citation statement)

References 8 publications

(13 reference statements)

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“…Literature searching revealed two reports of factitious disorders in PD context. They were also related to DDS and with an ultimate diagnosis of factitious disorder imposed on self 5 6. In both, functional and social impairments were critical and the patient was helped in order to resolve these difficulties.…”

Section: Discussionmentioning

confidence: 99%

Dopamine dysregulation syndrome induced by proxy

Carneiro¹,

Sousa

Morgadinho

et al. 2019

BMJ Case Rep

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Dopamine dysregulation syndrome is a rare complication of Parkinson’s disease (PD) treatment. We present a 70-year-old woman with a long-standing PD and a clinical picture compatible with dopaminergic dysregulation, which was ultimately revealed to be induced by her companion. Patient’s exuberant choreiform dyskinesia led to a potential financial advantage when performed outside the hospital but excessive dopamine intake also occurred during hospital admission, without any obvious reward for the abuser. Even in cases where there is no place for a definitive diagnosis, deceptive behaviours must be identified as their management is based on psychological and social support in parallel to the adjustment of PD therapy.

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Section: Discussionmentioning

confidence: 99%

Dopamine dysregulation syndrome induced by proxy

Carneiro¹,

Sousa

Morgadinho

et al. 2019

BMJ Case Rep

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Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease

2007

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Impulse control disorders (ICDs) constitute a group of relatively common psychiatric conditions. ICDs typically involve pleasurable or hedonic behaviors (e.g. gambling, shopping or sex) that are performed repetitively, excessively or compulsively, to an extent that interferes in major areas of life functioning. Over the past decade, case reports, case studies and controlled examinations have reported ICDs in neurological patients, particularly those with Parkinson's disease (PD). A relationship between dopamine agonist treatment and ICDs was initially suggested on the basis of clinical observations, and subsequent systematic studies have provided more-substantial support for this association. Ongoing studies of the clinical characteristics of individuals with PD with and without ICDs suggest that certain individuals might be at increased risk of developing ICDs during PD treatment. Emerging data suggest that the association between dopamine agonists and ICDs extends into other neurological patient populations in which these agents are employed, such as those with restless legs syndrome. In this article, we summarize current knowledge regarding ICDs, review their relationships with PD and its treatments, provide practical clinical recommendations based on existing data, and suggest avenues for future research directed at advancing clinical care strategies.

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Dopamine dysregulation syndrome in non-Parkinson’s disease patients: a systematic review

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Ramalingam

2019

Australas Psychiatry

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Objectives: To explore the presence of dopamine dysregulation syndrome in non-Parkinson’s disease patients receiving dopamine replacement therapy. Methods: Electronic searches were conducted of Medline, Embase, PsycINFO and PreMedline to capture articles related to dopamine misuse or factitious disorder combined with the presence of dopamine replacement therapy or a non-Parkinson’s disease population. In total, 430 articles were reviewed and studies that addressed dopamine dysregulation syndrome in non-Parkinson’s disease patients were included. Results: Nine case reports were identified. Conclusions: The pathophysiology underlying dopamine dysregulation syndrome has been thoroughly explored with numerous mechanisms posited. What remains unclear is whether dopamine dysregulation syndrome is a phenomenon specific to Parkinson’s disease, as indicated in the proposed diagnostic criteria. A more useful predictor of susceptibility to dopamine dysregulation syndrome may be temperamental traits such as novelty seeking and impulsivity, which overlap with predisposing factors for an addiction disorder.

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Factitious disorder mimicking addiction to levodopa in a patient with advanced Parkinson's disease

Cited by 3 publications

References 8 publications

Dopamine dysregulation syndrome induced by proxy

Dopamine dysregulation syndrome induced by proxy

Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease

Dopamine dysregulation syndrome in non-Parkinson’s disease patients: a systematic review

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