Facilitation of mounting behavior by dihydrotestosterone propionate in castrated estradiol benzoate-treated male rats following pudendectomy

Lodder, J.; Baum, Michael J.

doi:10.1016/s0091-6773(77)90720-9

Cited by 34 publications

(9 citation statements)

References 15 publications

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“…At present, it is unknown whether DHT acts solely in the periphery or exerts effects related to behavior by acting upon the central nervous system. There is some evi dence that it may [Lodder and Baum, 1977], but the levels at which these hormones act to influence behavior requires further elucidation.…”

Section: Discussionmentioning

confidence: 99%

Activation of Masculine Sexual Behavior by Intracranial Estradiol Benzoate Implants in Male Rats

1979

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Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered subcutaneously (s.c.) to each male. 25 of 42 males with EB implants located in the medial anterior hypothalamic-preoptic area (AHPOA) exhibited ejaculatory patterns on at least 40% of the post-implantation tests. In contrast, only 4 of 18 of the males with implants located posterior to the anterior hypothalamic area displayed this level of response. This difference in the proportion of animals responding for each implant group was statistically significant. Seminal vesicle weights were not correlated with the occurrence of copulation. In experiment 2, either EB-filled or empty cannulae were placed unilaterally in the AHPOA. Half of the males of each group also received DHT s.c. Intracranial EB in conjunction with DHT s.c. resulted in a significantly greater frequency of ejaculatory response than any other treatment. Despite significant differences among the groups in seminal vesicle weights, there was no correlation with occurrence of ejaculatory behavior. These results are consistent with the hypothesis that testosterone (T) exerts its effects upon masculine sexual behavior via conversion to estradiol (E₂); and that the principal neural site of action is the AHPOA.

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Section: Discussionmentioning

confidence: 99%

Activation of Masculine Sexual Behavior by Intracranial Estradiol Benzoate Implants in Male Rats

1979

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“…In the mammalian male, this dynamic process includes the secretion of androgens by the testes. These steroids, mostly (MacLusky & Naftolin, 1981;MacLusky, Philip, Hurlburt, & Naftolin, 1985), but not exclusively (Lodder & Baum, 1977), through their conversion to estrogens in situ, promote the sexual differentiation of the brain. In males, this differentiation process includes the suppression of cyclicity in gonadotropin secretion (van der Schoot & Zeilmaker, 1972), the inhibition of the expression of lordosis behavior (female sexual behavior) in adulthood (VegaMatuszczyk, Ferna Ândez-Guasti, & Larsson, 1988), the anatomical brain differences that characterize this sex (Gorski, Harlan, Jacobson, Shryne, & Southam, 1980;Guillamo Ân & Segovia, 1993) and the maleoriented differentiation of other behaviors, not necessarily directly related with reproductive phenomena (Konishi & Gurney, 1982).…”

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confidence: 99%

Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

et al. 2000

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“…These results suggest that despite differences in mount frequencies and intro mission rales that are consistently observed in pituitarygrafted rats when mated with a female [3,17,19], mounting rates (including mounts with and without intromission) in tests of copulatory behavior may serve as a reliable index of sexual arousal in hyperprolactinemic animals. This has also been shown to be true for the effects of various steroids on sexual activity [8,27]. Penile reflexes could be reliably eli cited in the Fischer rats used in these studies only after ejac ulation or spinal transection.…”

Section: Discussionmentioning

confidence: 73%

Effects of Chronic Hyperprolactinemia on Sexual Arousal and Erectile Function in Male Rats

1986

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Studies were conducted to determine if the inhibitory effects of chronic hyperprolactinemia on sexual behavior in male rats occur through reduced sexual arousal as opposed to reduced erectile function. Pituitary-grafted (hyperprolactinemic) and sham-operated, gonadally intact male rats were given standard tests of copulatory behavior, mounting behavior tests after genital anesthetization and penile reflex tests while restrained in a supine position. Beginning 7 days after pituitary transplantation, the number of erections displayed in penile reflex tests was significantly reduced in the pituitary-grafted animals. Increased intromission latencies and reduced intromission rates in tests of copulatory behavior were also observed at this time. Beginning 3–4 weeks after surgery, mounting rates were inhibited in hyperprolactinemic animals in both the copulatory behavior tests and tests of mounting behavior after genital anesthetization. Prolactin levels were significantly elevated in the pituitary-grafted animals, but serum testosterone levels were unaffected. To determine if the effects of hyperprolactinemia on erectile function occurred through changes in supraspinal input to neurons in the spinal cord controlling erectile function, pituitary-grafted and sham-operated male rats were subjected to spinal transection (between vertebral levels T6 and T9). Beginning 7 days later, penile reflex performance was re-examined. Hyperprolactinemic animals displayed significantly fewer erections during the initial test, but not in tests performed 10 and 13 days after spinal transection. The pituitary-grafted animals also showed a significant reduction in latency to the first erection with each successive test, suggesting a delayed recovery from increased supraspinal inhibitory input. These results show that hyperprolactinemia inhibits both sexual arousal and erectile function, and suggest that the inhibition of erectile function occurs through an effect of the hyperprolactinemic state at a supraspinal level within the central nervous system.

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Facilitation of mounting behavior by dihydrotestosterone propionate in castrated estradiol benzoate-treated male rats following pudendectomy

Cited by 34 publications

References 15 publications

Activation of Masculine Sexual Behavior by Intracranial Estradiol Benzoate Implants in Male Rats

Activation of Masculine Sexual Behavior by Intracranial Estradiol Benzoate Implants in Male Rats

Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

Effects of Chronic Hyperprolactinemia on Sexual Arousal and Erectile Function in Male Rats

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