Cell Reports volume 4, issue 1, P159-173 2013 DOI: 10.1016/j.celrep.2013.06.013 View full text
Henry Garcia, Jeffrey C. Miecznikowski, Alfiya Safina, Mairead Commane, Anja Ruusulehto, Sami Kilpinen, Robert W. Leach, Kristopher Attwood, Yan Li, Seamus Degan, Angela R. Omilian, Olga Guryanova, Olympia Papantonopoulou, Jianmin Wang et al.

Abstract: Summary The Facilitates Chromatin Transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a novel class of anti-cancer compounds and is not expressed in normal cells of adult mammalian tissues, except for undifferentiated and stem-like cells. Here, we show that FACT expression is strongly associated with p…

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