Facile Synthesis of Fluorescent Hyper-Cross-Linked β-Cyclodextrin-Carbon Quantum Dot Hybrid Nanosponges for Tumor Theranostic Application with Enhanced Antitumor Efficacy

Pei, Mingliang; Pai, Jui-Yu; Du, Pengcheng; Liu, Peng

doi:10.1021/acs.molpharmaceut.8b00508

Cited by 38 publications

(19 citation statements)

References 53 publications

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“…The nanocarriers equipped with defined functionality for tailored interaction through 'host-guest chemistry' , and biodegradable properties can ferry poorly soluble agents to selectively target cancer cells with stem-like properties and controllably release their payload in response to the environment, thus resulting in an improved antitumor activity in vivo. Pei et al [133] linked the β-cyclodextrin (β-CD) on the CDs to form β-CD-CDs, which further DOX can be loaded via host-guest complexation. The DOX -loading capacity can reach 39.5% and release in the weakly acidic tumor microenvironment.…”

Section: Mcf-7 Cellsmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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Section: Mcf-7 Cellsmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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“…Besides, protonation of AUR’s ether bonds and amide bond cleavage under acidic conditions may also be a cause of AUR release from the nanogel. 34 – 36 Taken together, the release of AUR and CDDP were obviously affected by the acidic environment, and the behavior of differential release in physiological conditions and tumor environment helped to improve the selectivity of drugs.…”

Section: Resultsmentioning

confidence: 99%

<p>pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer</p>

Cao¹,

Li²,

Li³

et al. 2020

IJN

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Introduction Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly. Methods Therefore, the biodegradable materials hyaluronic acid (HA) and β-cyclodextrin derivative (mono-(6-amino-mono-6-deoxy)-β-CD, CD) were employed as carriers to load AUR and CDDP to form nanogel ( CDDP HA-CD@AUR) capable of dual-targeted delivery and synergistic therapy for breast cancer and cell imaging. Results With the help of the CDDP-crosslinked CD-loaded structure, the newly synthesized nanogel exhibited excellent physiological stability and fluorescence effects. The release of AUR and CDDP was affected by the pH value, which was beneficial to the selective release in the tumor microenvironment. Cell experiments in vitro demonstrated that the nanogel could be selectively internalized by MCF-7 cells and exhibited low cytotoxicity to HK-2 cells. Antitumor experiments in vivo showed that the nanogel have better antitumor effects and lower systemic toxicity. Conclusion Based on these, the nanogel loaded with AUR and CDDP have the potential for targeted delivery against breast cancer.

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“…CQDS have been widely used in biological imaging. Carboxyl-functionalized carbon quantum dots are known to exhibit high quantum yield and abundant surface carboxyl groups, which could be used as cross-linking agents for β-CD, endowing fluorescent functions to β-CD (Figure 8 a) 112 . This cross-linked polymer has been shown exhibit both fluorescence imaging properties and drug delivery functions.…”

Section: Transport Of Theranostic Agentsmentioning

confidence: 99%

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Yi¹,

Liao²,

Zhao³

et al. 2022

Theranostics

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In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the required standard of effectiveness, primarily owing to issues of drug resistance exhibited by cancer cells and inherent differences among the patients. In this regard, combination therapy offers advantages of synergistic mechanism, reduced drug dosage, and enhanced therapeutic effect, which can be effectively utilized for the treatment of cancer. However, different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo , which lead to uncontrollable concentration ratio of therapeutic agents at the lesion site. This in turn causes serious side effects and affects synergistic anticancer effect. Importantly, multifunctional co-delivery systems are characterized by good pharmacokinetic properties, ability to provide targeted delivery, and controlled release in response to tumor microenvironment. Such delivery systems are widely used for co-delivery of therapeutic agents, which further assist in obtaining better synergistic anticancer effect, and can be potentially used for clinical application. Multifunctional co-delivery systems often exhibit complex structures and construction process. Since cyclodextrin is characterized by self-assembly property, it is possible to quickly construct cyclodextrin-based multifunctional co-delivery systems, with convenience and flexibility. The application of cyclodextrin in the construction of multifunctional co-delivery systems for cancer therapy has gained immense attention in the past few years. The present study provided overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy.

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Facile Synthesis of Fluorescent Hyper-Cross-Linked β-Cyclodextrin-Carbon Quantum Dot Hybrid Nanosponges for Tumor Theranostic Application with Enhanced Antitumor Efficacy

Cited by 38 publications

References 53 publications

Recent advance of carbon dots in bio-related applications

Recent advance of carbon dots in bio-related applications

<p>pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer</p>

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

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