Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine

Liu, Lefeng; Xu, Zhengguo; Liu, Yang; Yin, Zheng‐Zhi; Sheng, Yanshan; Ding, Chengqiang; Kong, Yong

doi:10.1016/j.jscs.2021.101344

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…This band appears as a strong absorption band at 1419 cm −1 in the original CKD spectrum due to the formation of CaCO 3 in CKD from atmospheric CO 2. 46 Finally, a very small, sharp band observed at 1384 cm −1 in the UNP sample spectrum is attributed to the vibration of nitrate traces produced during the dissolution of the CKD sample using HNO 3. 4…”

Section: X-ray Powder Diffraction (Xrd) Analysismentioning

confidence: 92%

Utilizing Undissolved Portion (UNP) of Cement Kiln Dust as a Versatile Multicomponent Catalyst for Bioethylene Production from Bioethanol: An Innovative Approach to Address the Energy Crisis

Nasr,

Abdelkader,

El-Nahas

et al. 2023

ACS Omega

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This study focuses on upcycling cement kiln dust (CKD) as an industrial waste by utilizing the undissolved portion (UNP) as a multicomponent catalyst for bioethylene production from bioethanol, offering an environmentally sustainable solution. To maximize UNP utilization, CKD was dissolved in nitric acid, followed by calcination at 500 °C for 3 h in an oxygen atmosphere. Various characterization techniques confirmed that UNP comprises five different compounds with nanocrystalline particles exhibiting an average crystal size of 47.53 nm. The UNP catalyst exhibited a promising bioethylene yield (77.1%) and selectivity (92%) at 400 °C, showcasing its effectiveness in converting bioethanol to bioethylene with outstanding properties. This exceptional performance can be attributed to its distinctive structural characteristics, including a high surface area and multiple-strength acidic sites that facilitate the reaction mechanism. Moreover, the UNP catalyst displayed remarkable stability and durability, positioning it as a strong candidate for industrial applications in bioethylene production. This research underscores the importance of waste reduction in the cement industry and offers a sustainable path toward a greener future.

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Section: X-ray Powder Diffraction (Xrd) Analysismentioning

confidence: 92%

Utilizing Undissolved Portion (UNP) of Cement Kiln Dust as a Versatile Multicomponent Catalyst for Bioethylene Production from Bioethanol: An Innovative Approach to Address the Energy Crisis

Nasr,

Abdelkader,

El-Nahas

et al. 2023

ACS Omega

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“…It is soluble in alcohols, methanamide or formamide, water and alkali water (pH of 8 or 9), and DMF. Theta solvents of PAA in which side chains react as perfect chains are 1,4-dioxane and 0.2 M aqueous hydrochloric acid [ 67 , 68 ]. It is also notable that theta solvents fall in between desirable and non-solvents.…”

Section: Synthesis and Structure Characteristicsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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“…The materials that served as the “gatekeeper” may respond sensitively to internal and/or external stimuli such as GSH, pH, and temperature, and thus the drug delivery can be facilely controlled through the “on–off” switch of the stimuli. Various stimuli-responsive materials such as poly(acrylic acid) (PAA), , polydopamine (PDA), , hyaluronic acid, , and so on have been proven to be competent candidates to block the mesopores of MSN and achieve stimuli-responsive drug delivery. ZnO quantum dots (QDs) are attractive in biomedical applications, since they are both of low cost and less toxic. , For instance, ZnO QDs can be utilized for the release of the chemotherapeutic drug doxorubicin for the treatment of lung cancer, and ZnO QDs can also be used as the carrier of insulin .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Controlled Drug Delivery Platform Based on Carboxylated Mesoporous Silica Nanoparticles––Zinc Oxide Quantum Dots

Li,

Chen,

Rui

et al. 2024

Ind. Eng. Chem. Res.

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A biodegradable delivery platform is constructed for controlled drug delivery. Carboxylated biodegradable mesoporous silica nanoparticles (COOH−BMSNs) are synthesized to load the chemotherapy drug methotrexate (MTX), and the mesopores of BMSN are blocked by ZnO quantum dots (QDs) through an amidation reaction to encapsulate the loaded MTX. The ZnO QDs are decomposed under mildly acidic conditions which is characteristic of a tumor microenvironment, resulting in the release of MTX; additionally, glutathione (GSH) can reduce the disulfide bonds (−S−S−) in a BMSN into sulfhydryl (−SH), causing the decomposition of the BMSN and the release of MTX. Therefore, the responsiveness of pH and GSH to MTX delivery can be achieved with ZnO−BMSN−MTX. Notably, in vitro cytotoxicity testing reveals that the drug-free carrier (ZnO−BMSN) exhibits good biocompatibility, whereas the controlled delivery platform (ZnO−BMSN−MTX) exhibits significant cytotoxicity against SMMC-7721 tumor cells benefiting from the synergistic effect of MTX and Zn 2+ .

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Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine

Cited by 8 publications

References 28 publications

Utilizing Undissolved Portion (UNP) of Cement Kiln Dust as a Versatile Multicomponent Catalyst for Bioethylene Production from Bioethanol: An Innovative Approach to Address the Energy Crisis

Utilizing Undissolved Portion (UNP) of Cement Kiln Dust as a Versatile Multicomponent Catalyst for Bioethylene Production from Bioethanol: An Innovative Approach to Address the Energy Crisis

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

Biodegradable Controlled Drug Delivery Platform Based on Carboxylated Mesoporous Silica Nanoparticles––Zinc Oxide Quantum Dots

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