Facial Localization of Malignant Chondroid Syringoma: A Rare Case Report

Tural, Deniz; Selçukbiricik, Fatih; Gunver, Feray; Karışmaz, Abdülkadir; Serdengecti, Suheyla

doi:10.1155/2013/907980

Cited by 21 publications

(32 citation statements)

References 15 publications

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“…Although most mixed tumors of skin are benign, malignant forms have been reported. Unlike its benign counterpart, the malignant form occurs predominantly in females [5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review

Wollina

Sturm²,

Schönlebe

2014

Wien Med Wochenschr

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Section: Introductionmentioning

confidence: 99%

Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review

Wollina

Sturm²,

Schönlebe

2014

Wien Med Wochenschr

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“…The histologic features of benign and malignant chondroid syringoma are similar, thus making morphology an unreliable predictor of malignancy. Most previously reported malignant chondroid syringomas were diagnosed by examination of metastases [3] . Importantly, we discovered that p16 was positive in both the metastatic malignant chondroid syringoma and the recurrent thigh lesion, but was undetected in the benign chondroid syringomas.…”

Section: Resultsmentioning

confidence: 99%

“…Most previously reported malignant chondroid syringomas were diagnosed by examination of metastases that typically involved lymph nodes, lung, or both [2] . Treatment is generally limited to radical surgical excision and possibly chemoradiation, although the latter is generally considered ineffective against these tumors [3] .…”

Section: Introductionmentioning

confidence: 99%

Tumor suppressor expression and genetic characterization of benign and malignant chondroid syringoma

Williams

Olsen

Coffey

et al. 2014

CRCP

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Chondroid syringoma is an uncommon epithelial and mesenchymal neoplasm of eccrine sweat glands. Most are benign, but some may exhibit aggressive behavior, including local recurrence and lymph node or distant metastases. Treatment is generally limited to radical surgical excision and possibly chemoradiation, although the latter is generally considered ineffective against these tumors. Histologic features of benign and malignant chondroid syringoma are similar, thus making morphology an unreliable marker for clinically aggressive behavior. Identification of biomarkers that predict clinical behavior would be potentially useful for selecting patients with malignant chondroid syringoma for targeted therapy. The purpose of this study was to investigate somatic mutations commonly involved in tumor pathways, and to determine if there is altered expression of tumor suppressors p16 and p53 in metastatic malignant versus benign chondroid syringoma. Five chondroid syringoma tissue samples were analyzed -2 aggressive and 3 benign. Immunostaining for tumor suppressor genes p16 and p53 was performed. Genomic DNA was isolated and genetic analysis was performed using a custom Sequenom MassArray. Chondroid syringomas with clinically aggressive behavior showed strong nuclear p16 expression in contrast to those with benign behavior. Both the malignant and benign chondroid syringomas demonstrated positive p53 expression with varying intensity. No somatic mutations were identified in any of the chondroid syringomas.

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“…The incidence of chondroid syringoma is very low, reported as 0.01% of all primary skin tumors. 20 Lesions are typically benign, are located on the head and neck, sparing the extremities, and affect middle-aged men. 15 Although most reported cases of chondroid syringoma have been benign, several cases of malignancy have been reported.…”

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confidence: 99%

“…15 Although most reported cases of chondroid syringoma have been benign, several cases of malignancy have been reported. [1][2][3][7][8][9]11,14,17,18,[20][21][22] Malignant chondroid syringoma is the least common variety of sweat gland carcinoma. 10,22 In contrast to its benign counterpart, the malignant form occurs predominantly in women of any age and is observed more commonly in the trunk and extremities.…”

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confidence: 99%

Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report

Menéndez¹,

Erice²,

Bas³

et al. 2015

SPI

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The authors describe a case of spinal cord compression due to an epidural metastasis of malignant chondroid syringoma. Chondroid syringoma is a rare mixed tumor of the skin composed of both epithelial and mesenchymal elements. Although most are benign, malignant forms have been reported. Malignant chondroid syringoma may progress very slowly and the metastatic spread occurs late, appearing years after the original diagnosis. There is only one other report of spinal cord compression secondary to metastasis of malignant chondroid syringoma, which was finally diagnosed by microscopic examination of an autopsy specimen. This 63-year-old woman presented with a 4-week history of progressive paraparesis. Admission MRI of the thoracic spine showed an extradural mass arising from the posterior elements and left pedicle of T-9, which caused posterior compression of the spinal cord. Surgical decompression resulted in resolution of the neurological impairments. The histological results were consistent with metastasis of malignant chondroid syringoma. The patient underwent adjuvant radiotherapy and a favorable outcome was noted at the 2-year follow-up visit. This represents the first reported case of spinal cord compression from a metastasis of a malignant chondroid syringoma histologically confirmed in vivo. The authors' experience in this case suggests that resection followed by radiotherapy might be an acceptable means for achieving short-term, progression-free survival.

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Facial Localization of Malignant Chondroid Syringoma: A Rare Case Report

Cited by 21 publications

References 15 publications

Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review

Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review

Tumor suppressor expression and genetic characterization of benign and malignant chondroid syringoma

Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report

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