Facial Colloid Degeneration in Plaques

Sullivan, M.E.

doi:10.1001/archderm.1961.01580170110015

Cited by 30 publications

(5 citation statements)

References 6 publications

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“…The third form, known as`nodular colloid degeneration', was first described by Labadie in 1927 10 and later by other authors. 11,12 It consists of isolated or multiple plaques and nodules 0´5±5´0 cm in diameter, 11 which are located predominantly on the face but can also develop on the trunk and extremities. Holzberger 13 reported CM of the hands in a group of 28 workers employed in an oil refinery in the tropics.…”

Section: Discussionmentioning

confidence: 99%

Papuloverrucous colloid milium: an occupational variant

Muscardin

Bellocci

Băluş

2000

British Journal of Dermatology

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We report a case of adult colloid milium in a 47-year-old mechanic with a long history of professional contact with lubricating oils and of sun exposure. In addition to the typical translucent papules seen on the forehead, there were warty papules on the backs of both hands with unusual histological and ultrastructural features: marked hyperplasia of the epidermis with orthokeratotic hyperkeratosis and papillary deposits of colloid material that were contiguous with the basal layer of the epidermis. The hand lesions caused by occupational exposure to mineral oils and solar radiation represent an occupational variant of adult colloid milium.

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Section: Discussionmentioning

confidence: 99%

Papuloverrucous colloid milium: an occupational variant

Muscardin

Bellocci

Băluş

2000

British Journal of Dermatology

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“…Colloid milium is a rare skin disease characterized by the presence of multiple, small, domeshaped, yellowish-brown, semitranslucent papules on sun-exposed areas. Since the first description of this dermatosis by Wagner (1866) approximately 100 cases of colloid milium have been reported in the literature (Beck & Wifling, i960;Becker & Wilson, 1956;Nodi, i967;Percival&Duthie, 1948;Piredda, 1958;Prakken, 1951;Sullivan & Ellis, 1961;Warin, 1961;Zoon et al, 1955). As already pointed out by Miedzinski et al (i960) two variants of this dermatosis can be differentiated: (i) The adult type, in which the lesions appear in middleaged persons-often caused by actinic and chemical influences (Ferreira-iMarques & von Oden, 1950;Findlay et al, 1975;Guin & Seale, 1959;Holzberger, i960;Miedzinski et al, i960;Rook, 1975)-and (2) the extremely rare juvenile type of colloid milium, which starts before puberty (Woolridge & Frcrichs, i960;Zaun, 1966).…”

Section: Discussionmentioning

confidence: 99%

Colloid milium: light and electron microscopic investigations

Ebner

Gebhart

1977

Clin Exp Dermatol

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Summary A case of colloid milium (‘juvenile type’) is presented. Histochemically the colloid material showed the well known similarity to amyloid where especially in the upper portions of the colloid immunoglobulin and complement depositions could be found. Fibrin was demonstrated predominantly in the periphery of individual colloid islands. Electron microscopically, colloid exhibited a fibrillary structure. On the surface of the islands as well as enclosed within the colloid material numerous desmosome‐like structures could be visualized and sometimes also nuclear remnants were present. In circumscribed areas a fibrillary transformation of keratinocytes was observed. On the basis of these findings it is concluded that colloid represents tonofilament‐like material and therefore is of epidermal origin.

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“…Colloid milium is currently classified into three different subtypes; (a) adult type (1-7), which occurs on sun-exposed areas such as face, ears, neck and dorsum of hands as small or confluent semi-translucent papules, (b) juvenile form (8), which has been attributed to keratinocyte degeneration and (c) pigmented colloid milium (9) associated with exogenous ochronisis due to hydroquinone bleaching cream among South African blacks. A vague entity called nodular colloid degeneration (10)(11)(12) or paracolloid of the skin (13) may represent a tumefactive nodular amyloidosis which is now characterized as an accumulation of light chain of immunoglobulins. (14,15).…”

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confidence: 99%

Juvenile colloid milium

et al. 1989

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A 7-year-old Italian girl with juvenile colloid milium was studied with histological, immunohistochemical, and electron microscopic methods. This patient had a well-documented history of severe sunburn and developed the lesions on the face shortly afterward. Numerous apoptotic keratinocytes were observed in the lower epidermis. These cells began their degeneration with filamentous whorl formation (or filamentous degeneration) of tonofilaments. In the papillary dermis the colloid substance was resolved by the electron microscopy into either wavy, thin filaments derived from the epidermal keratinocytes or typical amyloid filaments. Many desmosomes and gap junctions were found in the colloid substance. Polyclonal antikeratin antibody (DAKO) was positive in the colloid substance, particularly in the parts close to the epidermis. These findings suggested that juvenile colloid milium is different from adult colloid milium despite clinical similarities and that the former belongs to the group of actinic amyloid K, i.e. amyloidoses due to actinic degeneration of keratinocyte and its keratin.

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Facial Colloid Degeneration in Plaques

Cited by 30 publications

References 6 publications

Papuloverrucous colloid milium: an occupational variant

Papuloverrucous colloid milium: an occupational variant

Colloid milium: light and electron microscopic investigations

Juvenile colloid milium

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