Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro

Shor, Lauren; Güçeri, Selçuk I.; Wen, Xuejun; Gandhi, Milind; Sun, Wei

doi:10.1016/j.biomaterials.2007.08.018

Cited by 454 publications

(303 citation statements)

References 23 publications

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“…The ultimate compressive strength and elastic modulus for HA-poly-(L-lactic acid) (PLLA) parts fabricated by SLS was found within the lower limits of reported values for cancellous bone [6]. The beneficial effect of HA in composite scaffolds significantly depends on their microstructure, achieved density in designed solid regions and porosity of the scaffolds, sometimes exhibiting conflicting results [15,16]. CaPs are brittle materials with poor mechanical properties in torsion and bending.…”

Section: Introductionmentioning

confidence: 90%

Powder bed generation in integrated modelling of additive layer manufacturing of orthopaedic implants

Krzyżanowski

Svyetlichnyy

Stevenson

et al. 2016

Int J Adv Manuf Technol

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This paper presents an original model of powder bed generation developed within the frame of an integrated modelling approach for studying the interaction of physical mechanisms in additive layer manufacturing (ALM) of orthopaedic implants. The model is based on cellular automata (CA) approach and describes the relationship between moving particles of different sizes during deposition on a surface in three dimensions. The surface is defined by the horizontal two-dimensional CA on which particles fall and irreversibly stick to a growing deposit. The model allows for consideration of different restructuring cases when particles are allowed to rotate as often as necessary until achievement of a local minimum position. Changes in the packing density of the powder bed have been investigated numerically depending on technological parameters, such as particle size distribution, deposition rate and sequence of powder deposition. The model has been developed with the aim of merging to the finite element (FE)-based integrated model and is applicable to a different ranges of materials including metals and also non-metals.

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Section: Introductionmentioning

confidence: 90%

Powder bed generation in integrated modelling of additive layer manufacturing of orthopaedic implants

Krzyżanowski

Svyetlichnyy

Stevenson

et al. 2016

Int J Adv Manuf Technol

View full text Add to dashboard Cite

show abstract

“…However, the filament gap that induces the porosity should be corresponding to the filament diameter which means that the ratio of filament gap to filament diameter should be within a practical range. In reality, if the value of this ratio is above 3 the integrity of the fabrication process is hampered and stability of the scaffold structure is lost [16]. It is because of slacking of the filaments during polymer deposition, which ultimately interrupts the pore interconnectivity.…”

Section: Resultsmentioning

confidence: 99%

Prediction of Patient-Specific Tissue Engineering Scaffolds for Optimal Design

Chuan¹,

Hoque²,

Pashby³

2013

IJMO

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Abstract-The fabrication of patient-specific tissue engineering scaffold is highly appreciated that requires prior estimation of porous and mechanical characteristics. Architectural controllability and reproducibility are also essential aspects in the development of 3D functional scaffolds. This work presents a computational approach to determine porous and mechanical characteristics of 3D scaffolds. The computational modeling could be a powerful tool to assist designing 3D scaffold with optimum characteristics as required for a particular patient in need. The 3D scaffolds were successfully modeled investigating the influences of design parameters on the porous and mechanical properties via finite element analysis (FEA) and ANSYS application software. It was revealed by ANSYS that the increase in porosity decreased the mechanical properties and increased the damping factor. The Scaffold porosities were obtained in the range of 47% to 95% with varying pore shape and size by modulating lay-down pattern, filament diameter and filament distance. IndexTerms-Tissue engineering, scaffold, rapid prototyping, finite element analysis.

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“…When the concentration of nano-tubes exceeds 0.5 wt%, their orientation within the bers in the longitudinal aspect is disrupted. As mentioned, in order to enhance mechanical properties of polymers by nanoparticles, high amount of nanoparticles must be added to the basic polymer [34][35][36][37][38]. Shor et al added 25% of hydroxyapatite to poly(caprolactone) sca old to increase the mechanical properties of sca old [36].…”

Section: Identi Cation Of the Chemical Structure With Ftirmentioning

confidence: 99%

“…As mentioned, in order to enhance mechanical properties of polymers by nanoparticles, high amount of nanoparticles must be added to the basic polymer [34][35][36][37][38]. Shor et al added 25% of hydroxyapatite to poly(caprolactone) sca old to increase the mechanical properties of sca old [36]. By addition of 20 wt% to three di erent ceramic nanoparticles, namely Calcium Titanate (CT), Strontium Titanate (ST) and Barium Titanate (BT), Bagchi et al signi cantly increased the moduli and strength of poly(" caprolactone) [38].…”

Section: Identi Cation Of the Chemical Structure With Ftirmentioning

confidence: 99%

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

2016

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Abstract. The aim of this study is to evaluate the e ects of Multi-Walled Carbon NanoTubes (MWNTs) on the structural and mechanical properties of poly-3-hydroxybutyrate (P3HB) electrospun sca olds. To achieve optimal properties of the electrospinning machine, P3HB polymer solutions were prepared at di erent concentrations and spinned in di erent electrospinning parameters. After optimization, MWNTs in di erent weight percentages (0.5%, 0.75%, 1%, and 1.25%) were added to the polymer solutions and electrospinned. The e ects of MWNTs on the structure of bers were investigated using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR) techniques. The addition of MWNTs increased the average ber diameter from 210 (neat P3HB) to 700 nm at 1.25% MWNTs. In addition, SEM photomicrographs and the MATLAB software program showed an increase in porosity from 81% to 84% in the presence of MWNTs. Tensile strength of P3HB/MWNTs composites revealed 158% improvement over pure P3HB sca old. According to mechanical and structural properties, the best amount of MWNTs was 0.5 wt%. Therefore, MWNTs with low percentages can signi cantly improve the mechanical properties of pure P3HB sca old, so that they can become favorable mechanically for tissue engineering applications.

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Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro

Cited by 454 publications

References 23 publications

Powder bed generation in integrated modelling of additive layer manufacturing of orthopaedic implants

Powder bed generation in integrated modelling of additive layer manufacturing of orthopaedic implants

Prediction of Patient-Specific Tissue Engineering Scaffolds for Optimal Design

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

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