Fabrication of quantum dot/silica core–shell particles immobilizing Au nanoparticles and their dual imaging functions

Abstract

The present work proposes preparation methods for quantum dot/silica (QD/SiO 2 ) core-shell particles that immobilize Au nanoparticles (QD/SiO 2 /Au). A colloid solution of QD/SiO 2 core-shell particles with an average size of 47.0 ± 6.1 nm was prepared by a sol-gel reaction of tetraethyl orthosilicate in the presence of the QDs with an average size of 10.3 ± 2.1 nm. A colloid solution of Au nanoparticles with an average size of 17.9 ± 1.3 nm was prepared by reducing Au 3? ions with sodium citrate in water at 80°C. Introduction of amino groups to QD/SiO 2 particle surfaces was performed using (3-aminopropyl)-triethoxysilane (QD/SiO 2 -NH 2 ). The QD/SiO 2 /Au particles were fabricated by mixing the Au particle colloid solution and the QD/SiO 2 -NH 2 particle colloid solution. Values of radiant efficiency and computed tomography for the QD/ SiO 2 /Au particle colloid solution were 2.23 9 10 7 (p/s/ cm 2 /sr)/(lW/cm 2 ) at a QD concentration of 8 9 10 -7 M and 1180 ± 314 Hounsfield units and an Au concentration of 5.4 9 10 -2 M. The QD/SiO 2 /Au particle colloid solution was injected into a mouse chest wall. Fluorescence emitted from the colloid solution could be detected on the skin covering the chest wall. The colloid solution could also be X-ray-imaged in the chest wall. Consequently, the QD/SiO 2 /Au particle colloid solution was found to have dual functions, i.e., fluorescence emission and X-ray absorption in vivo, which makes the colloid solution suitable to function as a contrast agent for dual imaging processes.

The study of low-density silica generation, characterizations, catalytic activity, and hydrogen peroxide sensing applications

“…These materials are also biocompatible and contain low toxicity. Silica nanoparticles were easily combined with iron oxide, quantum dots, uorescent dye, gold, and other metal nanoparticles to form hybrid nanoparticles [18][19][20][21]. In this work, we developed low density silica particles based on organ silane modi cation and calcinations.…”

Dual-Responsive Micelles with Aggregation-Induced Emission Feature and Two-Photon Aborsption for Accurate Drug Delivery and Bioimaging

“…An inexpensive and highly sensitive fluorescence probe would be a great choice for designing dye-doped NPs to make NPs visible. − However, the clinic application of conventional fluorescence probes is limited by the nature of aggregation caused quenching (ACQ) of these dyes. − Luckily, an interesting photophysical phenomenon of aggregation-induced emission (AIE) for luminescent materials has been observed by Tang and his co-workers in 2001 . An AIE fluorescence probe is a kind of promising candidate for bioimaging.…”

Physics-chemical study for liquid glass from abundance distributed silicate mineral in Mongolia

“…элбэг тохиолдох үл уусах силикатуудыг уусгах ба тэдгээрийг саармагжуулахад өөрөө дахин эрэмбэлэгдэх замаар аморф цахиурыг үүсгэдэг онцлогтой аж [1][2][3][4][5]. Түүнчлэн эдгээр өвөрмөц шинж чанарт үндэслэн бусад барьцалдуулагчдаас урсамтгай чанар, бат бэх, хүчил, шүлт, уусгагчдад болон элэгдэлд тэсвэртэй чанар өндөртэй байдаг ба температурыг тэсвэрлэх чанар нь бусад барьцалдуулагчдаас 2.5-5 дахин их тул ангилал тус бүрээр улс ардын аж ахуйн бүх салбарт өргөн хэрэглэгддэг аж [1][2][3][4][5][6][7][8].…”