Fabrication of porous polymer microspheres by tuning amphiphilicity of the polymer and emulsion–solvent evaporation processing

Li, Ce; Wang, Wei; Wang, Xiaofan; Jiang, Hao; Zhu, Jintao; Lin, Shaoliang

doi:10.1016/j.eurpolymj.2015.05.011

Cited by 21 publications

(11 citation statements)

References 47 publications

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“…This is also consistent with our predictions for the internal morphologies of non-porosity particles at f B = 2/12, 3/12–4/12, and 5/12–6/12, respectively. Moreover, in the experiments of Li et al and Ku et al, they found that both the compositions of BCP and the surfactant concentration play important roles in the formation of porous structures, which is also consistent with our predictions. On the other hand, there are some differences between our predictions and related experimental observations.…”

Section: Resultssupporting

confidence: 93%

“…Among the resulting morphologies, anisotropic particles and porous particles are the two most interesting categories. For the former, extensive studies have been reported − as reviewed recently, whereas for the latter, studies are relatively scarce. − Experimentally, Li et al fabricated a series of particles with controllable size and porous structures by tuning polymer compositions and concentration of the polymer or surfactant in emulsion droplets of poly(4-vinylpyridie)- b -poly{6-[4-(4-butyloxyphenylazo)phenoxy]hexyl methacrylate} . Ku et al fabricated a series of porous BCP particles with controllable morphology and pore sizes by tuning the interfacial behavior of BCP polystyrene- b -poly(4-vinylpyridine) (PS- b -P4VP) droplets in oil-in-water emulsions.…”

Section: Introductionmentioning

confidence: 99%

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Formation Mechanisms of Porous Particles from Self-Assembly of Amphiphilic Diblock Copolymers inside an Oil-in-Water Emulsion Droplet upon Solvent Evaporation

et al. 2019

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The formation mechanisms of porous particles from self-assembly of amphiphilic diblock copolymers inside an oil-in-water emulsion droplet upon evaporation of the organic solvent are investigated based on Monte Carlo simulations for the first time. A morphological diagram of particles is constructed as a function of the surfactant concentration (φ) and the copolymer composition characterized by the volume fraction of the hydrophilic B block (f B ). Particles with various morphologies are predicted. Morphological sequences from nonporosity to closed-porosity to capsules and finally to open-porosity particles are usually observed with increasing φ when f B ≤ 1/2, with the only exception that capsules do not occur when f B = 1/6. Furthermore, the critical φ value for a given morphological transition usually decreases with increasing f B . Micelles are always observed at higher φ regions when f B > 1/2. It is found that the specific surface area falls on almost the same regime for particles with the same kind of morphology, indicating that the morphology of a particle largely determines its specific surface area. The chain stretching varies with the particle morphology. It is the presence of the surfactant that makes the formation of porous particles possible, while when φ > 0, multiple morphological transitions can be induced by changing f B . In the process of organic solvent removal, the value of f B may affect the shape of pores inside the droplet and hence leads to the f B dependence of the morphological sequences. When the solvent evaporation is not too fast, the resulting morphological sequence does not depend on the evaporation rate. Our results are compared with related experiments.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Formation Mechanisms of Porous Particles from Self-Assembly of Amphiphilic Diblock Copolymers inside an Oil-in-Water Emulsion Droplet upon Solvent Evaporation

et al. 2019

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“…Solvent evaporation is appropriate for encapsulating both hydrophilic and lipophilic drugs with high efficiency. 169 This method is performed in a water-in-oil (w/o) emulsion of polymer and is being prepared using an appropriate surfactant.…”

Section: Double Emulsion/solvent Evaporation Methodsmentioning

confidence: 99%

Inhaled antibiotic-loaded polymeric nanoparticles for the management of lower respiratory tract infections

Sabuj

Islam

2021

Nanoscale Adv.

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“…The pore size and diameters of particles were tuned by the polymer concentration and SDS concentration. 25 Recently, particles with tunable surface structures of biocompatible polymers were prepared by employing this method. 12 Hussain et al showed that poly(lactic-co-glycolic acid) (PLGA) particles with wrinkled and tentacle surfaces were prepared by adding PLGA-b-polyethylene glycol (PLGA-b-PEG).…”

Section: Interface Instability Of Emulsion Dropletsmentioning

confidence: 99%

Monodispersed polymer particles with tunable surface structures: Droplet microfluidic‐assisted fabrication and biomedical applications

Mao

Wang

Jin

et al. 2022

Journal of Polymer Science

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Polymer particles are key materials in various biomedical applications, including drug delivery, cellular immunity, cell capture, biochip, etc. Droplets produced by microfluidics have been widely applied as templates for the fabrication of polymer particles with controllable sizes and narrow size distributions. Compared to smooth polymer particles, those with surface microstructures (e.g., tentacles, bubbles, wrinkles and pits) are more attractive due to their increased surface area and biomimetic structural characteristics. In this review, we summarized representative methods for the preparation of monodispersed polymer particles with various surface microstructures based on droplet microfluidics, as well as their typical bioapplications in drug delivery, cellular immunity and cell capture. Finally, the current challenges and further development in this research area are discussed.

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Fabrication of porous polymer microspheres by tuning amphiphilicity of the polymer and emulsion–solvent evaporation processing

Cited by 21 publications

References 47 publications

Formation Mechanisms of Porous Particles from Self-Assembly of Amphiphilic Diblock Copolymers inside an Oil-in-Water Emulsion Droplet upon Solvent Evaporation

Formation Mechanisms of Porous Particles from Self-Assembly of Amphiphilic Diblock Copolymers inside an Oil-in-Water Emulsion Droplet upon Solvent Evaporation

Inhaled antibiotic-loaded polymeric nanoparticles for the management of lower respiratory tract infections

Monodispersed polymer particles with tunable surface structures: Droplet microfluidic‐assisted fabrication and biomedical applications

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