Fabrication of new generation of co-delivery systems based on graphene-g-cyclodextrin/chitosan nanofiber

Sattari, Shabnam; Tehrani, Abbas Dadkhah; Adeli, Mohsen; Soleimani, Khadijeh; Rashidipour, Marzieh

doi:10.1016/j.ijbiomac.2019.11.144

Cited by 30 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the size distribution graphs, the mean diameters of the composite nanofibrous scaffolds were 141.40 nm for CS/PG 0.1%, 126.23 nm for CS/PG 0.2% and 119.88 nm for CS/PG 0.5%, respectively. These changes can be attributed to the electrical conductivity of the electrospinning system which increased with the rising amount of GO-COOH [ 30 ]; at the same time, the conductivity is inversely proportional to the nanofiber diameter [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, Liu et al proved that the mechanical properties and antibacterial activity of CS/PVA nanofibers can be enhanced by the addition of GO [ 29 ]. In another study, Sattari and co-workers reported the successful design of a new generation of co-delivery systems based on graphene-g-cyclodextrin/chitosan nanofibers with core-shell architecture as a potent drug delivery system used in tumor inhibition and tissue regeneration [ 30 ]. The nanofibers presented a core-shell structure: curcumin; the therapeutic agent was encapsulated within the cyclodextrin-GO core, while to enhance the therapeutic activity of curcumin in the chitosan shell, gallic acid was added.…”

Section: Introductionmentioning

confidence: 99%

“…The literature reports few recent studies in which composite nanofibers based on CS and different amounts of GO are approached, to generate composite nanofibrous scaffolds with potential application in various fields of biomedicine [ 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and Characterization of Electrospun Composite Scaffolds Based on Chitosan-Carboxylated Graphene Oxide with Potential Biomedical Applications

et al. 2021

View full text Add to dashboard Cite

This research study reports the development of chitosan/carboxylated graphene oxide (CS/GO-COOH) composite scaffolds with nanofibrous architecture using the electrospinning method. The concept of designed composite fibrous material is based on bringing together the biological properties of CS, mechanical, electrical, and biological characteristics of GO-COOH with the versatility and efficiency of ultra-modern electrospinning techniques. Three different concentrations of GO-COOH were added into a chitosan (CS)-poly(ethylene oxide) (PEO) solution (the ratio between CS/PEO was 3/7 (w/w)) and were used in the synthesis process of composite scaffolds. The effect of GO-COOH concentration on the spinnability, morphological and mechanical features, wettability, and biological properties of engineered fibrous scaffolds was thoroughly investigated. FTIR results revealed the non-covalent and covalent interactions that could take place between the system’s components. The SEM micrographs highlighted the nanofibrous architecture of scaffolds, and the presence of GO-COOH sheets along the composite CS/GO-COOH nanofibers. The size distribution graphs showed a decreasing trend in the mean diameter of composite nanofibers with the increase in GO-COOH content, from 141.40 nm for CS/PG 0.1% to 119.88 nm for CS/PG 0.5%. The dispersion of GO-COOH led to composite scaffolds with increased elasticity; the Young’s modulus of CS/PG 0.5% (84 ± 4.71 MPa) was 7.5-fold lower as compared to CS/PEO (662 ± 15.18 MPa, p < 0.0001). Contact angle measurements showed that both GO-COOH content and crosslinking step influenced the surface wettability of scaffolds, leading to materials with ~1.25-fold higher hydrophobicity. The in vitro cytocompatibility assessment showed that the designed nanofibrous scaffolds showed a reasonable cellular proliferation level after 72 h of contact with the fibroblast cells.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Characterization of Electrospun Composite Scaffolds Based on Chitosan-Carboxylated Graphene Oxide with Potential Biomedical Applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…148 These problems have been overcome by combining CS with other biopolymers such as cellulose, dextrin, sodium alginate, and so on. [151][152][153][154] Multilayers of biopolymers can be disposed of on graphene through various techniques. 155,156 In a study, layer-by-layer (LbL) self-assembly technique has been explored for deposition of CS and dextrin on graphene surface.…”

Section: Dovepressmentioning

confidence: 99%

Functionalized Graphene Platforms for Anticancer Drug Delivery

Sattari¹,

Adeli²,

Beyranvand³

et al. 2021

IJN

Self Cite

View full text Add to dashboard Cite

Two-dimensional nanomaterials are emerging as promising candidates for a wide range of biomedical applications including tissue engineering, biosensing, pathogen incapacitation, wound healing, and gene and drug delivery. Graphene, due to its high surface area, photothermal property, high loading capacity, and efficient cellular uptake, is at the forefront of these materials and plays a key role in this multidisciplinary research field. Poor water dispersibility and low functionality of graphene, however, hamper its hybridization into new nanostructures for future nanomedicine. Functionalization of graphene, either by covalent or non-covalent methods, is the most useful strategy to improve its dispersion in water and functionality as well as processability into new materials and devices. In this review, recent advances in functionalization of graphene derivatives by different (macro)molecules for future biomedical applications are reported and explained. In particular, hydrophilic functionalization of graphene and graphene oxide (GO) to improve their water dispersibility and physicochemical properties is discussed. We have focused on the anticancer drug delivery of polyfunctional graphene sheets.

show abstract

“…The experiment’s results showed that the release rate of TCH (3 wt%)/PLLA (10 wt%) uniaxial blended nanofibers was 30% in the first 8 h, while the release rate of coaxial TCH (10 wt%)/PLLA (10 wt%) fibers was only 22.9% after 144 h. The core-shell nanofibers inhibited the initial release and promoted the continuous release of the drugs [ 12 ]. Compared with uniaxial electrospinning, coaxial nanofibers store and control the release of drugs, protect the biological activity of the drugs from the environment, achieve more lasting drug release, and have a better therapeutic effect [ 9 , 13 , 14 , 15 , 16 , 17 ]. In the process of coaxial electrospinning, changing the shell layer flow rate, the shell solution concentration, and the core layer flow rate can produce shell layers of different thicknesses and thus control the release rate [ 14 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications

Chen

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). Besides this, the in vitro drug release profile was investigated; it showed that the release rate of the prepared coaxial porous nanofibers with two different pore sizes was 30.10 ± 3.51% and 35.04 ± 1.98% in the first 30 min, and became 92.66 ± 3.13% and 88.94 ± 1.58% after 14 days. Compared with the coaxial nonporous nanofibers and nanofibers prepared by uniaxial electrospinning with or without pores, the prepared coaxial porous nanofibers revealed that the burst release was mitigated and the dissolution rate of the hydrophobic drugs was increased. The further antimicrobial activity demonstrated that the inhibition zone diameter of the coaxial nanofibers with two different pore sizes was 1.70 ± 0.10 cm and 1.73 ± 0.23 cm, exhibiting a good antibacterial effect against Staphylococcus aureus. Therefore, the prepared nanofibers with the coaxial porous structures could serve as promising drug delivery systems.

show abstract

Fabrication of new generation of co-delivery systems based on graphene-g-cyclodextrin/chitosan nanofiber

Cited by 30 publications

References 38 publications

Synthesis and Characterization of Electrospun Composite Scaffolds Based on Chitosan-Carboxylated Graphene Oxide with Potential Biomedical Applications

Synthesis and Characterization of Electrospun Composite Scaffolds Based on Chitosan-Carboxylated Graphene Oxide with Potential Biomedical Applications

Functionalized Graphene Platforms for Anticancer Drug Delivery

Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications

Contact Info

Product

Resources

About