Fabrication of nanoparticles from a synthesized peptide amphiphile as a versatile therapeutic cargo for high antiproliferative activity in tumor cells

Peptides as carriers of active ingredients: A review

“…Hydrophilic and hydrophobic cargos were loaded into peptides including silk fibroin peptide ( Li et al, 2021a , Li et al, 2021b ), histidine fatty peptide ( Zhang et al, 2019 ) and bis(pyrene)-cationic dipeptide, to prepare nanoparticles. Their scanning electron microscopy (SEM) results revealed spherical ( Nejabat et al, 2020 ; Sun et al, 2017a ), smooth surface and uniform distribution ( Das et al, 2020 ). However, some papers reported the contradictory conclusions.…”

“…The transformation of composite structures at different pH levels affected loading and accumulation active ingredients at the lesion, resulting in improved tumor inhibition in larger cylindrical structures through the enhanced permeability and retention effect (EPR) ( Moyer et al, 2014 ). Moreover, peptide carriers had been used to load and release various cargos, including hydrophilic and hydrophobic drugs, leading to the inhibition of tumor cells ( Das et al, 2020 ; Li et al, 2017 ). According to Guo et al, multiple drugs jointly promoted the accumulation at the targeting sites via co-delivery systems, resulting in an effective anti-tumor effect ( Guo et al, 2021 ).…”

Research progress on self-assembled nanodrug delivery systems

“…The release of 5FU in response to stimulation and the controlled release of CPT in nanoparticles by continuous diffusion effectively inhibited the proliferation of HeLa cell lines. 80…”