Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Eleftheriadis, Georgios K.; Monou, Paraskevi Kyriaki; Bouropoulos, Nikolaos; Boetker, Johan; Rantanen, Jukka; Jacobsen, Jette Bredahl; Vizirianakis, Ioannis S.; Fatouros, Dimitrios G.

doi:10.1016/j.xphs.2020.05.022

Cited by 54 publications

(32 citation statements)

References 62 publications

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“…Although an increasing number of sequential printing passes was performed, the determined moisture content was similar for all specimens. This was indicative of the tightly bound water molecules in the substrate's matrix, whereas a major amount of water molecules from the ink was instantly evaporated upon formation of liquid droplets at the printer's orifice and the dispersion of droplets onto the substrates [8]. Moreover, the TGA data assured that the observed mass alterations upon drying were exclusively attributed to water evaporation, as thermal decomposition phenomena of the incorporated materials were observed at higher temperatures, compared to the drying conditions (105 • C).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the 2D inkjet printing technology provides the potential to advance the loading of poorly soluble drugs in a medicinal formulation, following the exploitation of suitable solvents in the development of inks [6]. The inkjet printing technique has been coupled with other formulation approaches, to fabricate hybrid drug delivery systems [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Clobetasol, omeprazole, and hydrocortisone are representative model drugs which have been formulated for buccal delivery [22][23][24]. The applicability of various printing technologies for patient-centric buccal formulations has been demonstrated by previous reports, in terms of (i) incorporating personalized doses or thermolabile drugs, and (ii) fabricating multi-layered buccal films [4,8,9,25]. B-complex vitamins are vital compounds for the proper functioning of the nervous system, the conversion of glucose into energy, and the metabolism of fats and proteins [26].…”

Section: Introductionmentioning

confidence: 99%

“…These hydrophilic macromolecules contain hydrogen bond forming groups, thus favoring the adhesion to the buccal mucosa [39][40][41]. Propylene glycol was incorporated in the liquid ink as viscosity modifier, and has been reported to enhance the permeation and adhesion properties of buccal films [8,9,42]. Solubility studies, surface tension, and viscosity measurements were performed to determine the optimal liquid ink.…”

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

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“…This possibility of drug application has been untapped and poorly investigated. A buccal drug delivery system has some bioadhesive solid dosage forms, such as bioadhesive tablets, gels, patches, and mucosal bioadhesive films [ 1 , 2 , 3 ]. The patients have to place the bioadhesive system onto the buccal mucosa of the mouth.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

et al. 2021

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Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.

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Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

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Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create three‐dimensional (3D) objects or two‐dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for non‐healthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, whilst exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in the era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.This article is protected by copyright. All rights reserved

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Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Cited by 54 publications

References 62 publications

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

Inkjet Printing of Pharmaceuticals

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