Fabrication of elastomer arterial models  with specified compliance

Stevanov, M.; Baruthio, J.; Eclancher, Bernard

doi:10.1152/jappl.2000.88.4.1291

Cited by 30 publications

(21 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1. A similar tendency was observed by Stevanov et al (2000) who showed the measured vessel compliance at 1.04 mm wall thickness was 12.3% lower than the predicted value.…”

Section: Determination Of Compliancesupporting

confidence: 86%

“…At higher values of the pressure p, a deviation from the linear trend is detected. Stevanov et al (2000) found a value of 80 mmHg at a wall thickness of 1.04 mm, up to which the dilatation was linear. These authors also realized the critical pressure level to increase with wall thickness, such that the present finding is consistent with their conclusion.…”

Section: Determination Of Compliancementioning

confidence: 90%

See 1 more Smart Citation

A refractive index-matched facility for fluid–structure interaction studies of pulsatile and oscillating flow in elastic vessels of adjustable compliance

et al. 2009

View full text Add to dashboard Cite

The flow field in the respiratory and vascular system is known to be influenced by the flexibility of the walls. However, up to now, most of the experimental biofluidic investigations have been performed in rigid models due to the complexity and necessity of optical access. In this paper, a facility and measurement techniques for studying oscillating and pulsatile flow in elastic vessels will be described. The investigated vessel models have been adapted such that fluid-mechanical and structure-mechanical characteristics represent realistic blood flows in medium blood vessels. That is, characteristic parameters, i.e., the Reynolds and Womersley number, as well as mechanical properties of the flexible wall, i.e., the Young's modulus and the material compliance, have been chosen to reasonably represent realistic flow conditions. First, a method to manufacture elastic models, which mimic the structure-mechanical properties of vascular vessels is described. The models possess a tunable compliance and are made of transparent polydimethylsiloxane. Second, the experimental setup of the flow facility will be elucidated. The flow facility allows to mimic pulsatile flow at physiologically relevant Reynolds and Womersley numbers. The precise form of the flow cycle can individually be controlled. Water/glycerine is used as flow medium for refractive index matching particle image velocimetry (PIV) measurements. The PIV recordings not only allow to assess the mean cross-sectional flow field but also further enable to simultaneously detect the movement of the flexible wall. Additionally, the local wall-shear stress can be obtained from the single-pixel line resolved near-wall flow field. To confirm the flow conditions of the oscillatory laminar flow inside the flow facility and to evaluate the ability to assess the flow field, measurements in a straight, uniform diameter, rigid Plexiglas pipe under identical conditions to those of the oscillating flow in the flexible vessel have been performed. The measurements of oscillating flow in the rigid pipe corroborate the experimentally obtained flow field and the wall-shear stress to well confirm Womersley's analytical solution and thereby evidence the quality of the flow facility and of the measurement techniques. To further study the detectability of the vessel deformation, oscillating flow at Reynolds numbers based on the non-dilated vessel diameter D and peak velocities Re D ranging from 1,000 to 1,750 and at Womersley numbers a ranging from 5 to 17.5 has been investigated in an elastic vessel.

show abstract

“…1. A similar tendency was observed by Stevanov et al (2000) who showed the measured vessel compliance at 1.04 mm wall thickness was 12.3% lower than the predicted value.…”

Section: Determination Of Compliancesupporting

confidence: 86%

Section: Determination Of Compliancementioning

confidence: 90%

A refractive index-matched facility for fluid–structure interaction studies of pulsatile and oscillating flow in elastic vessels of adjustable compliance

et al. 2009

View full text Add to dashboard Cite

show abstract

“…8,19 This technique gives a reliable index of the regional AoStiff, 28,29 but represents only an estimate of the local AoStiff because it is a summation of the individual biomechanical properties of different arterial walls (that is, carotid, aorta, iliac and femoral arteries) located between the two recording sites. 30,31 Our data showed that IWV measurements are highly correlated with the carotid-femoral PWV, indicating that IWV also provides a reliable estimate of the regional AoStiff (see Figures 3 and 4).…”

Section: Discussionmentioning

confidence: 56%

Assessment of aortic stiffness by local and regional methods

et al. 2011

View full text Add to dashboard Cite

The stiffness of large arteries has an important role in cardiovascular hemodynamics. Aortic stiffness (AoStiff) can be assessed non-invasively with regional and local methods. In this paper, we compared these two techniques for evaluating AoStiff. Our subjects comprised of 118 consecutive patients (85 men, mean age: 49 ± 14 years). We evaluated regional AoStiff with carotid-femoral pulse wave velocity (PWV) measured with a tonometric technique and by bioelectrical impedance (BI) wave velocity (IWV). The local AoStiff was calculated from BI signals recorded at the chest. We used glyceryl trinitrate (GTN) to test the effect of peripheral vasodilatation on both methods in a subgroup of 52 patients (37 men, mean age: 52 ± 11 years). We found a significant correlation between IWV and PWV measurements (r¼0.88, Po0.0001) as well as between AoStiff and PWV measurements (r¼0.75, Po0.0001). GTN administration decreased mean arterial blood pressure by 4% (95% confidence interval: 2-8%, P¼0.002) without significant changes in AoStiff and regional IWV. Local AoStiff is correlated with regional measurements and is not influenced by changes in arterial pressure because of systemic peripheral vasodilatation.

show abstract

“…Different materials are available for manufacturing rigid models [4,8], typically for the purpose of carrying out visualization studies, for example, particle image velocimetry [9]. However, rigid models do not replicate the compliant properties of the vasculature.Flexible elastomer arterial models with varying wall thickness have been used for investigating hemodynamics of the aortic circulation [10,11], but a realistic compliant model of the pulmonary arteries has not been presented. In this study, we describe the manufacturing of a compliant pulmonary arterial model based on patient anatomy created with rapid prototyping.…”

mentioning

confidence: 99%

A Mock Circulatory System Incorporating a Compliant 3D‐Printed Anatomical Model to Investigate Pulmonary Hemodynamics

Knoops

Biglino

Hughes³

et al. 2016

Artificial Organs

View full text Add to dashboard Cite

A realistic mock circulatory system (MCS) could be a valuable in vitro testbed to study human circulatory hemodynamics. The objective of this study was to design a MCS replicating the pulmonary arterial circulation, incorporating an anatomically representative arterial model suitable for testing clinically relevant scenarios. A second objective of the study was to ensure the system's compatibility with magnetic resonance imaging (MRI) for additional measurements. A latex pulmonary arterial model with two generations of bifurcations was manufactured starting from a 3D-printed mold reconstructed from patient data. The model was incorporated into a MCS for in vitro hydrodynamic measurements. The setup was tested under physiological pulsatile flow conditions and results were evaluated using wave intensity analysis (WIA) to investigate waves traveling in the arterial system. Increased pulmonary vascular resistance (IPVR) was simulated as an example of one pathological scenario. Flow split between right and left pulmonary artery was found to be realistic (54 and 46%, respectively). No substantial difference in pressure waveform was observed throughout the various generations of bifurcations. Based on WIA, three main waves were identified in the main pulmonary artery (MPA), that is, forward compression wave, backward compression wave, and forward expansion wave. For IPVR, a rise in mean pressure was recorded in the MPA, within the clinical range of pulmonary arterial hypertension. The feasibility of using the MCS in the MRI scanner was demonstrated with the MCS running 2 h consecutively while Address correspondence and reprint requests to: Paul Knoops, 30 Guilford Street, London WC1N 1EH, UK. paul.knoops. 14@ucl.ac.uk. Author ContributionsConception and design of the work: PGMK, GB, ADH, SS, RT; experimental setup, data acquisition and analysis: PGMK, GB, LX; interpretation of the data: PGMK, GB, ADH, KHP, RT; drafting the manuscript: PGMK, GB, RT; all authors critically revised the manuscript, read and approved the final manuscript. Conflict of InterestThe authors declare no conflict of interest. Europe PMC Funders GroupAuthor Manuscript Artif Organs. Author manuscript; available in PMC 2017 July 15. Published in final edited form as:Artif Organs. 2017 July ; 41(7): 637-646. doi:10.1111/aor.12809. Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts acquiring preliminary MRI data. This study shows the development and verification of a pulmonary MCS, including an anatomically correct, compliant latex phantom. The setup can be useful to explore a wide range of hemodynamic questions, including the development of patientand pathology-specific models, considering the ease and low cost of producing rapid prototyping molds, and the versatility of the setup for invasive and noninvasive (i.e., MRI) measurements.Mock circulatory systems (MCS) are widely used to gather hydrodynamic data in vitro. They allow investigation of the cardiovascular system in both healthy and pathological scenarios, with t...

show abstract

Fabrication of elastomer arterial models with specified compliance

Cited by 30 publications

References 1 publication

A refractive index-matched facility for fluid–structure interaction studies of pulsatile and oscillating flow in elastic vessels of adjustable compliance

A refractive index-matched facility for fluid–structure interaction studies of pulsatile and oscillating flow in elastic vessels of adjustable compliance

Assessment of aortic stiffness by local and regional methods

A Mock Circulatory System Incorporating a Compliant 3D‐Printed Anatomical Model to Investigate Pulmonary Hemodynamics

Contact Info

Product

Resources

About