Fabrication of Dual Layer Polyvinyl Alcohol Transdermal Patch: Effect of Freezing-Thawing Cycles on Morphological and Swelling Ability

Sa’adon, Shafizah; Razak, Saiful Izwan Abd; Ismail, Al Emran; Fakhruddin, Khalida

doi:10.1016/j.procs.2019.09.027

Cited by 4 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The samples were attached to a fixture with a double-sided adhesive tape containing graphite. A low accelerating voltage (15 kV) and vacuum were used to investigate the structure of the cut patches at 500× magnification [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

“…PVA is a copolymer of vinyl acetate and vinyl alcohol that is widely utilized in pharmaceutical formulations for its biocompatible, non-toxic and hydrophilic properties [ 13 , 14 , 15 ]. The extensive use of PVA is dictated by its beneficial properties, such as outstanding film-forming capability, impressive adhesive and emulsifying characteristics, chemical resistance and mechanical stability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Formulation and Evaluation of Transdermal Patches Containing BGP-15

Bácskay,

Hosszú,

Budai

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

BGP-15 is an active ingredient with many advantages, e.g., beneficial cardiovascular and anti-inflammatory effects. The transdermal administration of BGP-15 has great potential, which has not been investigated yet, despite the fact that it is a non-invasive and safe form of treatment. The aim of our study was to formulate transdermal patches containing BGP-15 and optimize the production with the Box–Behnken design of experiment. The most optimal formulation was further combined with penetration enhancers to improve bioavailability of the active ingredient, and the in vitro drug release and in vitro permeation of BGP-15 from the patches were investigated. FTIR spectra of BGP-15, the formulations and the components were also studied. The most optimal formulation based on the tested parameters was dried for 24 h, with 67% polyvinyl alcohol (PVA) content and low ethanol content. The selected penetration enhancer excipients were not cytotoxic on HaCaT cells. The FTIR measurements and SEM photography proved the compatibility of the active substance and the vehicle; BGP-15 was present in the polymer matrix in dissolved form. The bioavailability of BGP-15 was most significantly enhanced by the combination of Transcutol and Labrasol. The in vitro permeation study confirmed that the formulated patches successfully enabled the transdermal administration of BGP-15.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Transdermal Patches Containing BGP-15

Bácskay,

Hosszú,

Budai

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto‐Sensitive Tissue Engineering Strategies

Demir,

Ulusal,

Ulusal

et al. 2024

Biopolymers

View full text Add to dashboard Cite

This work reports the assembly of mesoporous iron oxide nanoparticles (meso‐MNPs) with cryogel scaffolds composed of chitosan and gelatin. Meso‐MNPs with a particle size ranging from 2 and 50 nm, a surface area of 140.52 m2 g−1, and a pore volume of 0.27 cm3 g−1 were synthesized on a porous SiO2 template in the presence of PEG 6000 followed by leaching of SiO2. Different ratios of meso‐MNPs were successfully incorporated into chitosan:gelatin cryogels up to an amount equivalent to the entire amount of polymer. The morphological structure and physicochemical properties of the cryogels were directly affected by the amount of MNPs. VSM curves showed that all composite cryogels could be magnetized by applying a magnetic field. In the context of the safety of magnetic cryogel scaffolds for use in biomedicine, it is important to note that all values are below the exposure limit for static magnetic fields, and according to cytotoxicity data, scaffolds containing meso‐MNPs showed nontoxicity with cell viability ranging from 150% to 275%. In addition, microbial analysis with gram‐negative and gram‐positive bacteria showed that the scaffolds exhibited activity against these bacteria.

show abstract

A New Lotus-Leaf-Inspired Beaded Nanofiber Strategy for the Development of Cryogel/Nanofiber Hybrid Structures

Kanmaz,

Osman,

Karaca

2024

Fibers Polym

View full text Add to dashboard Cite

In this study, a cryogel/nanofiber hybrid material was developed using a new lotus-leaf-inspired strategy. The lotus effect was generated via beaded poly(ε-caprolactone) (PCL) nanofibers produced from the 9 wt% PCL solution with low viscosity and high surface tension via electrospinning. A poly(hydroxyethyl methacrylate) (PHEMA) cryogel layer was constructed through polymerization onto the beaded PCL nanofibrous mat. The thickness of the PHEMA cryogel/beaded PCL nanofiber hybrid material was 3.19 ± 0.07 mm. Morphological characterization studies of the hybrid material were conducted by scanning electron microscopy (SEM). The mean diameter of the beaded PCL nanofibers was 97.22 ± 21.18 nm. The lotus effect created by the beaded PCL nanofibers was investigated by water contact angle (WCA) measurements. The WCA of beadless and beaded PCL nanofibers was 93.42° ± 1.4° and 117.97° ± 5.04°, respectively. The PHEMA cryogel layer was chemically characterized via Fourier transform infrared spectroscopy (FTIR) analysis and the specific groups belonging to 2-hydroxyethyl methacrylate (HEMA) was observed. The porosity of the PHEMA cryogel layer was determined via mercury porosimetry. The total porosity of the PHEMA cryogel was 64.42%, and the pore sizes were in the range of 5–200 µm. Swelling kinetics of the PHEMA cryogel/beaded PCL nanofiber hybrid material were also investigated and compared to those of PHEMA cryogel and beaded PCL nanofibers. The maximum swelling ratio of the hybrid material was 509.69% and reached after 180 min. The developed PHEMA cryogel/beaded PCL nanofiber hybrid material met the criteria required for layered structures and biomedical applications whereby its eligible stability, morphology, porosity, and swelling capacity. Consequently, the lotus-leaf-inspired strategy was successful in constructing the cryogel/nanofiber hybrid materials.

show abstract

Fabrication of Dual Layer Polyvinyl Alcohol Transdermal Patch: Effect of Freezing-Thawing Cycles on Morphological and Swelling Ability

Cited by 4 publications

References 13 publications

Formulation and Evaluation of Transdermal Patches Containing BGP-15

Formulation and Evaluation of Transdermal Patches Containing BGP-15

Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto‐Sensitive Tissue Engineering Strategies

A New Lotus-Leaf-Inspired Beaded Nanofiber Strategy for the Development of Cryogel/Nanofiber Hybrid Structures

Contact Info

Product

Resources

About