Fabrication of carbonate apatite honeycomb and its tissue response

Ishikawa, Kunio; Munar, Melvin L.; Tsuru, Kanji; Miyamoto, Youji

doi:10.1002/jbm.a.36640

Cited by 22 publications

(14 citation statements)

References 43 publications

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“…To refine the mechanical and biological behavior of inorganic composite materials, a great deal of interest has focused on organic polymer coatings [1]. As a biopolymer, HCB is interesting for its fully interconnected pores of uniform size and high mechanical strength in the direction of the pores [26]. The HCB architecture is identified by orderly unidirectional macropore or channel that penetrate the materials.…”

Section: Introductionmentioning

confidence: 99%

Carbonated Hydroxyapatite-Based Honeycomb Scaffold Coatings on a Titanium Alloy for Bone Implant Application—Physicochemical and Mechanical Properties Analysis

et al. 2021

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In this work, carbonated hydroxyapatite (CHA) based on abalone mussel shells (Haliotis asinina) is synthesized using the co-precipitation method. The synthesized CHA was mixed with honeycomb (HCB) 40 wt.% for the scaffold fabrication process. CHA and scaffold CHA/HCB 40 wt.% were used for coating a Titanium (Ti) alloy using the electrophoretic deposition dip coating (EP2D) method with immersion times of 10, 20, and 30 min. The synthesized B-type CHA with a stirring time of 45 min could have lower transmittance values and smaller crystallite size. Energy dispersive X-ray spectroscopy (EDS) showed that the Ca/P molar ratio was 1.79. The scaffold CHA/HCB 40 wt.% had macropore size, micropore size, and porosity of 102.02 ± 9.88 μm, 1.08 ± 0.086 μm, and 66.36%, respectively, and therefore it can also be applied in the coating process for bone implant applications due to the potential scaffold for bone growth. Thus, it has the potential for coating on Ti alloy applications. In this study, the compressive strength for all immersion time variations was about 54–83 MPa. The average compression strengths of human cancellous bone were about 0.2–80 MPa. The thickness obtained was in accordance with the thickness parameters required for a coating of 50–200 μm.

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Section: Introductionmentioning

confidence: 99%

Carbonated Hydroxyapatite-Based Honeycomb Scaffold Coatings on a Titanium Alloy for Bone Implant Application—Physicochemical and Mechanical Properties Analysis

et al. 2021

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“…Many compounds are more soluble than CO 3 Ap, and thus can be precursors for the fabrication of CO 3 Ap through dissolution-precipitation reactions including CaCO 3 [6][7][8][9][10][11][12][13][14][15][16][17][18], α-tricalcium phosphate [19][20][21][22][23][24], dicalcium phosphate dihydrate [25,26], and CaSO 4 [27][28][29][30]. Moreover, a component that is lacking can be supplied from aqueous solution.…”

Section: Co 3 Ap Fabrication Though Dissolution-precipitation Reaction Using a Precursormentioning

confidence: 99%

Carbonate apatite artificial bone

Ishikawa

Hayashi

2021

Science and Technology of Advanced Materials

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Bone apatite is not hydroxyapatite (HAp), it is carbonate apatite (CO 3 Ap), which contains 6-9 mass% carbonate in an apatitic structure. The CO 3 Ap block cannot be fabricated by sintering because of its thermal decomposition at the sintering temperature.Chemically pure (100%) CO 3 Ap artificial bone was recently fabricated through a dissolution-precipitation reaction in an aqueous solution using a precursor, such as a calcium carbonate block. In this paper, methods of fabricating CO 3 Ap artificial bone are reviewed along with their clinical and animal results. CO 3 Ap artificial bone is resorbed by osteoclasts and upregulates the differentiation of osteoblasts. As a result, CO 3 Ap demonstrates much higher osteoconductivity than HAp and is replaced by new bone via bone remodeling. Granular-type CO 3 Ap artificial bone was approved for clinical use in Japan in 2017. Honeycomb-type CO 3 Ap artificial bone is fabricated using an extruder and a CaCO 3 honeycomb block as a precursor. Honeycomb CO 3 Ap artificial bone allows vertical bone augmentation. A CO 3 Ap-coated titanium plate has also been fabricated using a CaCO 3 -coated titanium plate as a precursor. The adhesive strength is as high as 76.8 MPa, with excellent tissue response and high osteoconductivity.

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“…Therefore, an interconnected porous structure is promising for artificial bone substitutes, enabling faster bone replacement. 33) Fabrication of interconnected porous CO 3 Ap is promising for a quicker replacement of the lost bone with new bone.…”

Section: Future Of Artificial Bone Replacementmentioning

confidence: 99%

Carbonate apatite bone replacement: learn from the bone

Ishikawa

2019

J. Ceram. Soc. Japan

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Bone is not composed of hydroxyapatite (HAp), but of carbonate apatite (CO 3 Ap). Although the decomposition of CO 3 Ap begins at around 400°C, and thus, the fabrication of CO 3 Ap blocks by sintering is difficult, CO 3 Ap blocks have recently been fabricated via a dissolutionprecipitation reaction in Na 2 HPO 4 solution using a CaCO 3 block as a precursor. Compared to sintered HAp, which is not resorbed by osteoclasts, CO 3 Ap is resorbed by osteoclasts. Furthermore, CO 3 Ap upregulates the differentiation of osteoblasts. Therefore, CO 3 Ap can be used as a replacement for bones with regards to the so-called bone remodeling process. Clinical trials have confirmed the safety and usefulness of CO 3 Ap granules, including the replacement of CO 3 Ap granules to new bone. In Dec 2017, CO 3 Ap was approved as an artificial bone substitute by the Pharmaceuticals and Medical Devices Agency. CO 3 Ap granules can be used for all dental and maxillofacial surgeries, including the bone reconstruction aimed for dental implantation.

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Fabrication of carbonate apatite honeycomb and its tissue response

Cited by 22 publications

References 43 publications

Carbonated Hydroxyapatite-Based Honeycomb Scaffold Coatings on a Titanium Alloy for Bone Implant Application—Physicochemical and Mechanical Properties Analysis

Carbonated Hydroxyapatite-Based Honeycomb Scaffold Coatings on a Titanium Alloy for Bone Implant Application—Physicochemical and Mechanical Properties Analysis

Carbonate apatite artificial bone

Carbonate apatite bone replacement: learn from the bone

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