Fabrication, mechanical properties and in vitro degradation behavior of newly developed Zn Ag alloys for degradable implant applications

Sikora-Jasinska, Malgorzata Urszula; Mostaed, Ehsan; Mostaed, Ali; Beanland, Richard; Mantovani, Diego; Vedani, Maurizio

doi:10.1016/j.msec.2017.04.023

Cited by 221 publications

(138 citation statements)

References 47 publications

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“…These results support the previously reported increase in corrosion rate with increasing silver content by Sikora-Jasinska et al 22 The alloying of zinc with low amounts (0·5 wt%) of magnesium did shift the initial OCP anodically, suggesting increased surface reactivity, but no significant increased corrosion rate was observed in the PDP measurements. However, when the amount of magnesium was increased to 3 wt%, an increase in initial corrosion rate similar to that of Zn4Ag was observed.…”

Section: Discussionsupporting

confidence: 92%

“…The insert in Figure 1(b) shows a high-magnification SEM image of a AgZn 3 particle. 22,23 The Zn0·5Mg alloy microstructure was characterized by primary zinc dendrites (light areas) with size of approximately 20 mm and precipitates of a magnesium-containing eutectic structure at the grain boundaries (dark areas) (Figure 1(c)). A high-resolution SEM image of the eutectic structure is included in Figure S2 in the online supplementary material.…”

Section: Composition and Microstructurementioning

confidence: 99%

“…18 More recently, a number of studies were published suggesting zinc-magnesium, zinc-aluminum (Al), zinc-lithium (Li) and zinc-silver (Ag) as potential biodegradable alloys. [19][20][21][22] The zinc-silver alloy was shown to possess high mechanical strength as well as superplasticity. 22 Current knowledge suggests zinc alloys to be a promising new class of biodegradable metals.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22] The zinc-silver alloy was shown to possess high mechanical strength as well as superplasticity. 22 Current knowledge suggests zinc alloys to be a promising new class of biodegradable metals. However, there is still a lack of understanding of what effect alloying has on the corrosion mechanism and temporal evolution of the surface properties in a biologically relevant environment.…”

Section: Introductionmentioning

confidence: 99%

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Zn-Mg and Zn-Ag Degradation Mechanism Under Biologically Relevant Conditions

Törne

Khan

Örnberg

et al. 2017

Surface Innovations

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Zinc (Zn) alloys form a promising new class of biodegradable metals that combine suitable mechanical properties with the favorable degradation properties of pure zinc. However, the current understanding of the influence of alloying elements on the corrosion of zinc alloys, in biologically relevant media, is limited. The authors studied the degradation of three alloys, zinc-4 wt% silver (Ag), zinc-0·5 wt% magnesium (Mg) and zinc-3 wt% magnesium by in situ electrochemical impedance spectroscopy (EIS). After exposure for 1 h or 30 d, the samples were characterized by infrared spectroscopy and scanning electron microscopy. The presence of secondary phases in the alloy microstructure induced selective corrosion and increased the degradation rate. EIS analysis revealed an increase in surface inhomogeneity already at short (hours) immersion times. The microgalvanic corrosion of the zinc-silver alloy resulted in enrichment of the AgZn 3 phase at the sample surface. The enrichment of silver and potential release of AgZn 3 particles may result in complications during the tissue regeneration. The zinc-magnesium alloy surface was depleted of the magnesium-rich phase after 8-12 d. The selective dissolution caused local precipitation of corrosion products and a thicker corrosion layer with larger pore size consistent with increased corrosion rate.

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Section: Discussionsupporting

confidence: 92%

Section: Composition and Microstructurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Zn-Mg and Zn-Ag Degradation Mechanism Under Biologically Relevant Conditions

Törne

Khan

Örnberg

et al. 2017

Surface Innovations

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“…Zinc (Zn) as the second most abundant transition metal element in the human body is found in all organs, tissues, fluids, and body secretions [54,55]. It is considered to be one of the vital mineral elements participating in a variety of fundamental biological functions, including signal transduction, apoptosis regulation as well as nucleic acid metabolism, DNA and RNA polymerase, and organic ligands interactions [56][57][58].…”

Section: Advantages Of Zn and Its Alloysmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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