Fabrication and Properties of Electrospun Magnetoelectric Graphene/Fe₃O₄/Poly(lactic-co-glycolic acid) Short Nanofibers

Electrospun short fibers: a new platform for cancer nanomedicine applications

“…Homogenization treatment aims to break the nanofiber membrane into SFs of a certain length with the help of the mechanical shear force generated by the homogenizing cutter head when running at a high speed. For example, Li et al [32] prepared electrospun gelatin/PLA fibrous mats. The mats were then cut into small pieces, dispersed in tert-butanol solution, and then homogenized to ensure even dispersion, followed by high-speed centrifugation.…”

Design of DNA Aptamer-Functionalized Magnetic Short Nanofibers for Efficient Capture and Release of Circulating Tumor Cells

“…Due to their outstanding merits, such as large specific surface area, good biocompatibility, extracellular matrix-mimicking property, and easy fabrication and surface modification, electrospun nanofibers have been widely explored for cancer cell capture applications. − The large specific surface area and abundant surface groups of nanofibers provide numerous sites for targeting ligand immobilization . For instance, in our previous study, we show that hyaluronic acid- or folic acid-functionalized nanofibers can be incorporated with a microfluidic chip system for efficient capture of CD44 receptor- or folic acid receptor-overexpressing cancer cells and CTCs. ,, In addition, electrospun nanofibers can be processed to form individual short nanofibers with a length ranging from 2 to 100 μm. − Meanwhile, inorganic nanoparticles (NPs), such as halloysite nanotubes, multiwalled carbon nanotubes, , laponite nanodisks, etc., can be easily incorporated within nanofibers through a blend electrospinning process. Therefore, it is reasonable to speculate that magnetic short fibers may be prepared to achieve the same goal for cell separations but with enhanced flexibility, high affinity, and easy operation capability.…”