Fabrication and characterization of microfluidic probes for convection enhanced drug delivery

Neeves, Keith B.; Lo, Catherine T.; Foley, Conor P.; Saltzman, W. Mark; Olbricht, William L.

doi:10.1016/j.jconrel.2005.11.018

Cited by 113 publications

(96 citation statements)

References 45 publications

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“…Drug penetration distance is limited by a slow diffusion coefficient coupled with a high rate of elimination (Haller & Saltzman 1998). In many instances, tissue exposed to therapeutic levels of drug concentration is limited at millimetres of the implant (Haller & Saltzman 1998;Mahoney & Saltzman 1999;Neeves et al 2006). Convection-enhanced delivery (CED) offers an alternative approach that uses pumps and catheters to create an external pressure gradient to infuse drug-containing fluid into the tissue, so that the transport is dominated by convection (Hall & Sherr 2006;Sawyer et al 2006;Ferguson et al 2007).…”

Section: Review Biomaterials For the Cns Y Zhong And R V Bellamkomentioning

confidence: 99%

Biomaterials for the central nervous system

Zhong

Bellamkonda

2008

J. R. Soc. Interface.

217

163

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Biomaterials are widely used to help treat neurological disorders and/or improve functional recovery in the central nervous system (CNS). This article reviews the application of biomaterials in (i) shunting systems for hydrocephalus, (ii) cortical neural prosthetics, (iii) drug delivery in the CNS, (iv) hydrogel scaffolds for CNS repair, and (v) neural stem cell encapsulation for neurotrauma. The biological and material requirements for the biomaterials in these applications are discussed. The difficulties that the biomaterials might face in each application and the possible solutions are also reviewed in this article.

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Section: Review Biomaterials For the Cns Y Zhong And R V Bellamkomentioning

confidence: 99%

Biomaterials for the central nervous system

Zhong

Bellamkonda

2008

J. R. Soc. Interface.

217

163

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“…We reasoned that the use of a porous hollow fiber catheter instead of a single-lumen infusion device would decrease deforming forces on the tissue surrounding the catheter and consequently increase bulk flow and total distribution of the infusate. 20 We used a hollow fiber catheter made of polysulfone with pore diameters of 0.45 μm, thereby providing multiple pathways for infusate to travel around each cell in the brain, which can be anywhere from 10 to 100 μm in diameter. As an initial test we used a 3-mm hollow fiber catheter and compared the distribution of dye injected into agarose gel and mouse brain relative to the distribution achieved with a 28-gauge needle, which is commonly used to deliver viral and nonviral vectors into the brain via CED.…”

Section: Introductionmentioning

confidence: 99%

Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter

Oh¹,

Odland

Wilson

et al. 2007

JNS

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Object-A hollow fiber catheter was developed to improve the distribution of drugs administered via direct infusion into the central nervous system (CNS). It is a porous catheter that significantly increases the surface area of brain tissue into which a drug is infused.Methods-Dye was infused into the mouse brain through convection-enhanced delivery (CED) using a 28-gauge needle compared with a 3-mm-long hollow fiber catheter. To determine whether a hollow fiber catheter could increase the distribution of gene therapy vectors, a recombinant adenovirus expressing the firefly luciferase reporter was injected into the mouse striatum. Gene expression was monitored using in vivo bioluminescent imaging. To assess the distribution of gene transfer, an adenovirus expressing green fluorescent protein was injected into the striatum using a hollow fiber catheter or a needle.Results-Hollow fiber catheter-mediated infusion increased the volume of brain tissue labeled with dye by 2.7 times relative to needle-mediated infusion. In vivo imaging revealed that cathetermediated infusion of adenovirus resulted in gene expression that was 10 times greater than that mediated by a needle. The catheter appreciably increased the area of brain transduced with adenovirus relative to a needle, affecting a significant portion of the injected hemisphere.Conclusions-The miniature hollow fiber catheter used in this study significantly increased the distribution of dye and adenoviral-mediated gene transfer in the mouse brain compared with the levels reached using a 28-gauge needle. Compared with standard single-port clinical catheters, the hollow fiber catheter has the advantage of millions of nanoscale pores to increase surface area and bulk flow in the CNS. Extending the scale of the hollow fiber catheter for the large mammalian brain shows promise in increasing the distribution and efficacy of gene therapy and drug therapy using CED.

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“…Silicon intracortical probes with integrated microfluidic channels have been fabricated to enable controlled localised delivery [32,33,52,53,54]. In vivo experiments have demonstrated the feasibility of delivering chemicals into relevant volumes of reactive tissue [32,33,53].…”

Section: Integrated Microfabricated Systemsmentioning

confidence: 99%

Controlled delivery for neuro-bionic devices

Yue

Moulton

Cook

et al. 2013

Advanced Drug Delivery Reviews

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Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used.

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Fabrication and characterization of microfluidic probes for convection enhanced drug delivery

Cited by 113 publications

References 45 publications

Biomaterials for the central nervous system

Biomaterials for the central nervous system

Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter

Controlled delivery for neuro-bionic devices

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